Rate Enhancement Research Articles

Constructing Nano-Heterostructure with Dual-Site to Boost H2O2 Activation and Regulate the Transformation of Free Radicals.

A major issue with Fenton-like reaction is the excessive consumption of H2O2 caused by the sluggish regeneration rate of low-valent metal, and how to improve the activation efficiency of H2O2 has become a key in current research. Herein, a nano-heterostructure catalyst (1.0-MnCu/C) based on nano-interface engineering is constructed by supporting Cu and MnO on carbon skeleton, and its kinetic rate for the degradation of tetracycline hydrochloride is 0.0436 min-1, which is 2.9 times higher than that of Cu/C system (0.0151 min-1). The enhancement of removal rate results from the introduced Mn species can aggregate and transfer electrons to Cu sites through the electron bridge Mn-N/O-Cu, thus preventing Cu2+ from oxidizing H2O2 to form O2 •-, and facilitating the reduction of Cu2+ and generating more reactive oxygen species (1O2 and ·OH) with stronger oxidation ability, resulting in H2O2 utilization efficiency is 1.9 times as much as that of Cu/C. Additionally, the good and stable practical application capacity in different bodies demonstrates that it has great potential for practical environmental remediation.

IMBA: IoT-Mist Bat-Inspired Algorithm for Optimising Resource Allocation in IoT Networks

The advent of the Internet of Things (IoT) has revolutionised our interaction with the environment, facilitating seamless connections among sensors, actuators, and humans. Efficient task scheduling stands as a cornerstone in maximising resource utilisation and ensuring timely task execution in IoT systems. The implementation of efficient task scheduling methodologies can yield substantial enhancements in productivity and cost-effectiveness for IoT infrastructures. To that end, this paper presents the IoT-mist bat-inspired algorithm (IMBA), designed specifically to optimise resource allocation in IoT environments. IMBA’s efficacy lies in its ability to elevate user service quality through enhancements in task completion rates, load distribution, network utilisation, processing time, and power efficiency. Through comparative analysis, IMBA demonstrates superiority over traditional methods, such as fuzzy logic and round-robin algorithms, across all performance metrics.

Scalable and rapid building damage detection after hurricane Ian using causal Bayesian networks and InSAR imagery

Timely and accurate assessment of hurricane-induced building damage is crucial for effective post-hurricane response and recovery efforts. Recently, remote sensing technologies provide large-scale optical or Interferometric Synthetic Aperture Radar (InSAR) imagery data immediately after a disastrous event, which can be readily used to conduct rapid building damage assessment. Compared to optical satellite imageries, the Synthetic Aperture Radar can penetrate cloud cover and provide more complete spatial coverage of damaged zone in various weather conditions. However, these InSAR imageries often contain highly noisy and mixed signals induced by co-occurring or co-located building damage, flood, flood/wind-induced vegetation changes, as well as anthropogenic activities, making it challenging to extract accurate building damage information. In this paper, we introduced a causality-informed Bayesian network inference approach for rapid post-hurricane building damage detection from InSAR imagery. This approach encoded complex causal dependencies among wind, flood, building damage, and InSAR imagery using a holistic causal Bayesian network. Based on the causal Bayesian network, we further jointly inferred the large-scale unobserved building damage by fusing the information from InSAR imagery with prior physical models of flood and wind, without the need for ground truth labels. Furthermore, we validated our estimation results in a real-world devastating hurricane—the 2022 Hurricane Ian. We gathered and annotated building damage ground truth data in Lee County, Florida, and compared the introduced method’s estimation results with the ground truth and also benchmarked it against state-of-the-art models to assess the effectiveness of our proposed method. The results show that our method advances building damage assessment after hurricanes by accurately reflecting the complex dynamics between wind and flood impacts. Notably, it achieves this without the need for a ground truth label, which is a substantial step forward from traditional methods. Our model registers a 22.6% increase in the Area Under the Curve (AUC) and a 46.29% enhancement in the True Positive Rate (TPR). Moreover, it expedites the detection of building damage, cutting down processing times by up to 83.8%. These improvements mark a considerable leap in efficiency, demonstrating our method’s ability to streamline the assessment process markedly over conventional methods.

Alpha effect-driven enhancement of CO2 capture kinetics and size-controlled NaHCO3 crystals: Promoter-added NaOH absorbent study

In this study, the kinetics of the transition of Na2CO3 to NaHCO3 were enhanced based on the alpha effect by adding rate promoters to NaOH-based absorbents. Because the α-effect shows strong correlation with the electronegativity of the α-atom, to analyze their kinetic improvement, H2O2, NaOCl, and H3BO3 were selected as rate promoters. The promoters were chosen based on compounds with an O− or OH– group that can act as a Lewis base when CO2 acts as a Lewis acid or a structure that is easily accessible to CO2 molecules. Each promoter was added at different concentrations (0.05, 0.1, and 0.2 M), and the reaction rates of the absorbent solutions were experimentally evaluated. Among selected promoters, H2O2 exhibits the greatest effect, achieved the highest conversion efficiency, which showed an approximately 45-fold increase in reaction rate compared to the promoter-free NaOH solution. Furthermore, the enhancement in reaction rate allows the particle size to be controlled and precipitated with different crystalline structure. Therefore, the introduction of a promoter based on the α-effect not only significantly improves the reaction rate leading to NaHCO3 formation but also allows control of the crystal size and shape. This breakthrough can be a promising solution to address the limitations of conventional NaOH absorbents.

Au/Ti3C2/g-C3N4 Ternary Composites Boost H2 Evolution Efficiently with Remarkable Long-Term Stability by Synergistic Strategies.

The use of novel two-dimensional MXene materials and conventional g-C3N4 photocatalysts to fabricate the composites for hydrogen evolution reaction (HER) has attracted much attention, for which there is plenty of room for the enhancement of hydrogen evolution rates particularly under visible light and photostability. Herein, g-C3N4 was modified by copolymerization of malonamide and melamine and used to fabricate the ternary composites of Au particles and Ti3C2 MXene, and based on the synergistic effect, the composites enhanced the hydrogen evolution rates by 2.1, 99.8, and ∞ times compared with the unmodified g-C3N4 under UV, simulated sunlight, and visible light illumination, respectively. Moreover, the composite exhibited a sustained hydrogen evolution capacity in the cycle test for up to 120 h. Theoretical calculations and experimental results indicated that the hot electrons of Au are injected into the modified g-C3N4 and transferred to Ti3C2 simultaneously along with the photogenerated electrons of the modified g-C3N4 and then further transferred to Au, forming a photogenerated electron transfer channel of Au and modified g-C3N4 → Ti3C2 → Au within the composite. Ti3C2 acts as a bridge for fast separation of photogenerated electrons and holes on Au and modified g-C3N4, playing a key role in the enhanced photocatalytic performance. In addition, the visible light absorption ability of Au also positively contributed to the enhancement of visible light photocatalytic performance by providing hot electrons. Therefore, the selection of suitable cocatalysts for the design of composites is a crucial research direction to improve the photocatalytic performance and photostability of photocatalysts.

Membrane localization accelerates association under conditions relevant to cellular signaling

Translocation of cytoplasmic molecules to the plasma membrane is commonplace in cell signaling. Membrane localization has been hypothesized to increase intermolecular association rates; however, it has also been argued that association should be faster in the cytosol because membrane diffusion is slow. Here, we directly compare an identical association reaction, the binding of complementary DNA strands, in solution and on supported membranes. The measured rate constants show that for a 10-µm-radius spherical cell, association is 22- to 33-fold faster at the membrane than in the cytoplasm. The kinetic advantage depends on cell size and is essentially negligible for typical ~1 µm prokaryotic cells. The rate enhancement is attributable to a combination of higher encounter rates in two dimensions and a higher reaction probability per encounter.

Binary Interaction Can Yield a Diversity of Circumstellar Media around Type II Supernova Progenitors

Recent observations of supernovae (SNe) have indicated that a fraction of massive stars possess dense circumstellar medium (CSM) at the moment of their core collapses. They suggest the presence of additional activities of the SN progenitor driving the enhancement of the mass-loss rate, and some physical processes attributing to a single star’s activities have been considered. In this study, we carry out binary evolutionary simulations of massive stars by MESA and investigate effects on the subsequent CSM formation through hydrodynamical simulations by PLUTO. We show that the mass transfer rate in a binary can increase at the beginning of the Roche lobe overflow, and this enhancement would be associated with the structure of the CSM before the explosion. We also illustrate that, depending on the orbital period of the binary, the density structure of the CSM can have a diverse distribution, including shell-like and cliff-like structures. These characteristic structures appear within the length scale of ∼1017 cm and could be traced by long-term observations of SNe, if the slow velocity of the CSM is assumed (∼10 km s−1). Our results highlight the importance of binary interaction in the aspect of reproducing the diversity of the CSM configuration.

Non-linear electro-rheological model of a membrane immersed in Tanner-Power law fluids applied to outer hair cells: Shear-thinning mechanisms

Flexoelectric actuation employs an applied electric field to induce membrane curvature, which is the mechanism utilized by the outer hair cells (OHC) present in the inner ear. The model developed for this study, representing the OHC, integrates two key components: (i) an approximation of the flexoelectric membrane shape equation for circular membranes attached to the inner surface of a circular capillary, and (ii) the coupled capillary flow of contacting liquid viscoelastic phases characterized by the Tanner-Power law rheological equation of state. A second-order non-linear differential equation for average curvature has been derived, and a robust numerical method has been programmed. This model simplifies to a linear model used previously. The main challenge involves identifying and describing the enhancement in curvature change rate. It was observed that low symmetry, low viscosity, and soft membrane and shear-thickening behavior of the phases enhance the curvature change rate. Additionally, there exists a critical electric field frequency value that maximizes the curvature change rate (resonance effect). The current theory, model, and computational simulations add to the ongoing development comprehension of how biological membrane shape actuation through electromechanical couplings.

New insights on testicular cancer prevalence with novel diagnostic biomarkers and therapeutic approaches.

Testicular cancer (TC), comprising merely 1% of male neoplasms, holds the distinction of being the most commonly encountered neoplasm among young males. Most cases of testicular neoplasms can be classified into two main groups, namely germ cell tumors representing approximately 95% of the cases, and sex cord-stromal tumors accounting for about 5% of the cases. Moreover, its prevalence is on the rise across the globe. TC is a neoplastic condition characterized by a favorable prognosis. The advent of cisplatin-based chemotherapeutic agents in the latter part of the 1970s has led to a significant enhancement in the 5-year survival rate, which presently surpasses 95%. Given that TC is commonly detected before reaching the age of 40, it can be anticipated that these individuals will enjoy an additional 40-50 years of life following successful treatment. The potential causes of TC are multifactorial and related to different pathologies. Accurate identification is imperative to guarantee the utmost efficacious and suitable therapy. To a certain degree, this can be accomplished through the utilization of blood examinations for neoplastic indicators; nonetheless, an unequivocal diagnosis necessitates an evaluation of the histological composition of a specimen via a pathologist. TC is multifactorial and has various pathologies, therefore this review aimed to revise the prenatal and postnatal causes as well as novel diagnostic biomarkers and the therapeutic strategies of TC.

Co-rotating twin screw process for continuous manufacturing of solid crystal suspension: A promising strategy to enhance the solubility, permeation and oral bioavailability of Carvedilol

Background In the current work, co-rotating twin-screw processor (TSP) was utilized to formulate solid crystal suspension (SCS) of carvedilol (CAR) for enhancing its solubility, dissolution rate, permeation and bioavailability using mannitol as a hydrophilic carrier. Methods In-silico molecular dynamics (MD) studies were done to simulate the interaction of CAR with mannitol at different kneading zone temperatures (KZT). Based on these studies, the optimal CAR: mannitol ratios and the kneading zone temperatures for CAR solubility enhancement were assessed. The CAR-SCS was optimized utilizing Design-of-Experiments (DoE) methodology using the Box-Behnken design. Saturation solubility studies and in vitro dissolution studies were performed for all the formulations. Physicochemical characterization was performed using differential scanning calorimetry , Fourier transform infrared spectroscopy, X-ray diffraction studies, and Raman spectroscopy analysis. Ex vivo permeation studies and in vivo pharmacokinetic studies for the CAR-SCS were performed. Stability studies were performed for the DoE-optimized CAR-SCS at accelerated stability conditions at 40 ºC/ 75% RH for three months. Results Experimentally, the formulation with CAR: mannitol ratio of 20:80, prepared using a KZT of 120 ºC at 100 rpm screw speed showed the highest solubility enhancement accounting for 50-fold compared to the plain CAR. Physicochemical characterization confirmed the crystalline state of DoE-optimized CAR-SCS. In-vitro dissolution studies indicated a 6.03-fold and 3.40-fold enhancement in the dissolution rate of optimized CAR-SCS in pH 1.2 HCl solution and phosphate buffer pH 6.8, respectively, as compared to the pure CAR. The enhanced efficacy of the optimized CAR-SCS was indicated in the ex vivo and in vivo pharmacokinetic studies wherein the apparent permeability was enhanced 1.84-fold and bioavailability enhanced 1.50-folds compared to the plain CAR. The stability studies showed good stability concerning the drug content. Conclusions TSP technology could be utilized to enhance the solubility, bioavailability and permeation of poor soluble CAR by preparing the SCS.

Crossflow polymeric hollow fiber heat exchanger: fiber tension effects on heat transfer and airside pressure drop

In various applications, a polymeric hollow fiber heat exchanger (PHFHE) is a competitive alternative to a conventional heat exchanger (HE). Standard empirical models for predicting the crossflow tube HE characteristics are defined for devices with rigid tubes with relatively large diameters compared to the polymeric hollow fibers with an outer diameter of around 1 mm. This study examines the impact of tension force on airside heat transfer rate and pressure drop in a crossflow PHFHE. The tension force influences the stiffness of the flexible polymeric fibers and their response to applied airflow. Two liquid–gas PHFHEs were designed and manufactured to ensure uniformity of the fibers' arrangement (inline and staggered). An experimental stand enabling the application of defined tension force in the range of 0–9000 N was designed, manufactured and placed into the calorimetric tunnel, where heat transfer rate and pressure drop measurement were performed with varying air velocity between 2 and 8 ms−1 (corresponding to Reynolds number of 240–970). Among our key findings was that the elongation of the fibers due to thermal expansion or stress relaxation has a considerable impact on the fibers' arrangement and resulting fluid flow. Moreover, the application of tension force yielded no substantial change in air pressure drop; however, it led to a notable enhancement in heat transfer rate. Specifically, under a maximal tension force of 9000 N, the heat transfer rate increased by around 11% compared to the unloaded state.

Dynamic uniaxial compression mechanical properties of self-compacting rubber concrete subjected to different strain rates

Rubber concrete is a kind of light green building material, which is prepared by mixing rubber powder or rubber crumb into ordinary concrete in a certain proportion and then introducing rubber concrete through vibration-free technology to prepare self-compacting rubber concrete. Uniaxial compression tests were carried out on self-compacting rubber concrete with two particle sizes at different strain rates, and the effects of strain rate and rubber content on the dynamic mechanical properties of self-compacting rubber concrete were studied. The microstructure of self-compacting rubber concrete before and after damage was analyzed. Compared with ordinary concrete, the self-compacting rubber concrete is capable of maintaining good integrity during damage, when the rubber powder content exceeds 10% and the rubber crumb content exceeds 15%. The results indicate that as the strain rate increases, both the peak stress and the elastic modulus increase, indicating the strain rate enhancement effect, while the strain rate effect of the peak strain is not evident. Moreover, the model equations of peak stress and elastic modulus strain rate effect were established, the dynamic damage constitutive model was proposed, the damage evolution was analyzed, and the stress intervals were assigned to the various stages of damage evolution.

Tuning light-driven oxidation of styrene inside water-soluble nanocages

Selective functionalization of innate sp2 C-H bonds under ambient conditions is a grand synthetic challenge in organic chemistry. Here we combine host-guest charge transfer-based photoredox chemistry with supramolecular nano-confinement to achieve selective carbonylation of styrene by tuning the dioxygen concentration. We observe exclusive photocatalytic formation of benzaldehyde under excess O2 (>1 atm) while Markovnikov addition of water produced acetophenone in deoxygenated condition upon photoexcitation of confined styrene molecules inside a water-soluble cationic nanocage. Further by careful tuning of the nanocage size, electronics, and guest preorganization, we demonstrate rate enhancement of benzaldehyde formation and a complete switchover to the anti-Markovnikov product, 2-phenylethan-1-ol, in the absence of O2. Raman spectroscopy, 2D 1H-1H NMR correlation experiments, and transient absorption spectroscopy establish that the site-selective control on the confined photoredox chemistry originates from an optimal preorganization of styrene molecules inside the cavity. We envision that the demonstrated host-guest charge transfer photoredox paradigm in combination with green atom-transfer reagents will enable a broad range of sp2 carbon-site functionalization.

Microgreens and novel non-thermal seed germination techniques for sustainable food systems: a review.

There are a number of cutting-edge techniques implemented in the germination process, including high pressure processing, ultrasonic, ultraviolet, light, non-thermal plasma, magnetic field, microwave radiation, electrolyzed oxidizing water, and plasma activated water. The influence of these technological advances on seed germination procedure is addressed in this review. The use of these technologies has several benefits, including the enhancement of plant growth rate and the modulation of bioactive chemicals like ABA, protein, and peroxidase concentrations, as well as the suppression of microbial development. Microgreens' positive health effects, such as their antioxidant, anticancer, antiproliferative/pro-oxidant, anti-obesity, and anti-inflammatory properties are extensively reviewed. The phytochemical and bioactive components of microgreens were investigated, including the concentrations of vitamin K, vitamin C, vitamin E, micro and macro nutrients, pro-vitamin A, polyphenols, and glucosinolates. Furthermore, the potential commercial uses of microgreens, as well as the current market transformation and prospects for the future are explored.

Combined eutexia and amorphization for simultaneous enhancement of dissolution rate of triamterene and hydrochlorothiazide: Preparation of orodispersible tablets

ABSTRACT Background: Triamterene is an oral antihypertensive drug with dissolution-limited poor bioavailability. It can be used as monotherapy or in fixed dose combination with hydrochlorothiazide which also suffers from poor dissolution. Moreover, co-processing of drugs in fixed dose combination can alter their properties. Accordingly, pre-formulation studies should investigate the effect of co-processing and optimize the dissolution of drugs before and after fixed dose combination. This is expected to avoid deleterious interaction (if any) and to hasten the biopharmaceutical properties. Objective: Accordingly, the aim of this work was to optimize the dissolution rate of triamterene alone and after fixed dose combination with hydrochlorothiazide. Methodology: Triamterene was subjected to dry co-grinding with xylitol, HPMC-E5 or their combination. The effect of co-grinding with hydrochlorothiazide was also tested in absence and presence of xylitol and HPMC-E5. The products were assessed using Fourier-transform infrared (FTIR), differential scanning calorimetry, X-ray powder diffraction (XRPD), in addition to dissolution studies. Optimum formulations were fabricated as oral disintegrating tablets (ODT). Results: Co-processing of triamterene with xylitol formed eutectic system which hastened dissolution rate. HPMC-E5 resulted in partial amorphization and improved triamterene dissolution. Co-grinding with both materials combined their effects. Co-processing of triamterene with hydrochlorothiazide resulted in eutexia but the product was slowly dissolving due to aggregation. This problem was vanished in presence of HPMC-E5 and xylitol. Compression of the optimum formulation into ODT underwent fast disintegration and liberated acceptable amounts of both drugs. Conclusion: The study introduced simple co-processing with traditional excipients for development of ODT of triamterene and hydrochlorothiazide.

Development of an Ir/TiO2 catalytic coating for plasma assisted hydrogenation of CO2 to CH4

The hydrogenation of CO2 to methane over a 20 wt% Ir/TiO2 catalytic coating has been investigated in a tubular dielectric barrier discharge (DBD) reactor. The 1.2 µm Ir/TiO2 coating was deposited onto the inner wall of a quartz tube by a combustion-evaporation method from a mixture containing a Ti precursor and a colloidal suspension of Ir nanoparticles (2 nm). The catalyst was characterised by XRD, SEM, TEM/EDS and CO chemisorption. The Ir(0) state in the as-synthesised film was confirmed by XPS. The CH4 conversion increased by 1.5 times, as compared to an empty tube. A maximum CO2 conversion rate of 2.1 μmol s−1 was achieved at a fuel production efficiency of 3.5%. Surface reactions onto the catalyst surface are responsible for enhancement of reaction rate. The results presented in this work open up new possibilities in plasma-catalysis, whereby efficient reactions can be carried out over small volumes of catalyst.

Interfacial chemical reactivity enhancement.

Interfacial enhancements of chemical reaction equilibria and rates in liquid droplets are predicted using a combined theoretical and experimental analysis strategy. Self-consistent solutions of reaction and adsorption equilibria indicate that interfacial reactivity enhancement is driven primarily by the adsorption free energy of the product (or activated complex). Reactant surface activity has a smaller indirect influence on reactivity due to compensating reactant interfacial concentration and adsorption free energy changes, as well as adsorption-induced depletion of the droplet core. Experimental air-water interfacial adsorption free energies and critical micelle concentration correlations provide quantitative surface activity estimates as a function of molecular structure, predicting an increase in interfacial reactivity with increasing product size and decreasing product polarity, aromaticity, and charge (but less so for anions than cations). Reactions with small, neutral, or charged products are predicted to have little reactivity enhancement at an air-water interface unless the product is rendered sufficiently surface active by, for example, interactions with interfacial water dangling OH groups, charge transfer, or voltage fluctuations.

Immunotherapy in Gastric Cancer: A Review

Globally, gastric cancer (GC) ranks fourth in terms of cancer-related mortality. Patients diagnosed with advanced gastric cancer (AGC) frequently have a median survival around 12-15 months, depending to the therapy. Immunotherapy is becoming an essential therapeutic strategy in medical oncology, and it is projected to make major advances to the way gastric cancer cure. The phase III ATTRACTION-2 showed that nivolumab, a monoclonal antibody targeting programmed cell death 1 (PD-1), substantially increased overall survival (OS) in patients with advanced gastric cancer (AGC) when given as a third- or later-line treatment, as compared to a placebo. Furthermore, nivolumab in combination with 5-fluorouracil and platinum as a first-line treatment increased OS in patients with human epidermal growth factor receptor-2 (HER2)-negative AGC in the international phase III CheckMate-649 investigation. Pembrolizumab, an additional anti PD-1 antibody, when used with trastuzumab and cytotoxic chemotherapy as first line treatment, demonstrated a substantial enhancement in the overall response rate among patients diagnosed with HER2-positive AGC. Hence, immune checkpoint inhibitors (ICIs) are crucial in the present management of GC. Current research is actively investigating alternative treatment following ICI combination therapy, including ICI rechallenge or combination therapy with drugs that have distinct mechanisms of action. Several clinical trials are presently being done to employ immunotherapy as a treatment option in the perioperative and postoperative settings for patients with early gastric cancer, based on the success of immunotherapy in treating advanced gastric cancer (AGC). This article gives an overview of the recent breakthroughs in immunotherapy.

Smart forwarding deceptive jamming distribution optimal algorithm

AbstractWith the frequent occurrence of drone black flying in large stadiums and airports, the requirement of precise electromagnetic interference to achieve unmanned aerial vehicle (UAV) displacement and forced landing in these protected area became urgent. Since traditional suppression jamming will affect normal communication, and forwarding deceptive jamming has coverage hole, a smart forwarding deceptive jamming distribution optimal algorithm (SFDJDO) is proposed. It gives a mapping error scale factor and the optimal distribution of multistation forwarding equivalent mapping to solve the problem of distortion on the mapping scale caused by different distribution methods and reduces the influence of the mapping errors and the differences between the virtual and real point neighborhoods of the jamming source. A comparison of the proposed SFDJDO method to the existing jamming source distribution optimisation method is conducted in the aspect of area mapping and trajectory mapping. The findings reveal that when the GNSS receiver clock bias is within the capture range, SFDJDO demonstrates significant enhancements in mapping precision and jamming success rates.

Neuroprotective effects of levothyroxine on cognition deficits and memory in an experimental model of Huntington's disease in rats: An electrophysiological study.

Huntington's disease (HD) is a neurodegenerative disorder characterized by cognitive deficits and motor function. Levothyroxine (L-T4) is a synthetic form of Thyroxine (T4), which can improve cognitive ability. The aim of the present study was to determine the neuroprotective effect of L-T4 administration in rats with 3-nitropropionic acid (3-NP)-induced Huntington's disease. Forty-eight Wistar male rats were divided into six groups (n = 8): Group 1 control group that received physiological saline, Group 2 and 3: which received L-T4 (30 and 100μg/kg), Group 4: HD group that received 3-NP and Groups 5 and 6: The treatment of the HD rats with L-T4 (30 and 100μg/kg). Spatial memory, locomotor activity, and frequency of neuronal firing were assessed. After decapitation, the Brain-Derived Neurotrophic Factor (BDNF) and Total antioxidant capacity (TAC) levels in the striatum was measured. The results showed that the indices of spatial memory (mean path length and latency time) and motor dysfunction (immobility time) significantly increased, while time spent in the goal quadrant, swimming speed, spike rate, and striatum levels of BDNF significantly decreased in the HD group compared to the control group. L-T4 treatment significantly enhanced time spent in the goal quadrant, swimming speed, motor activity (number of line crossing and rearing), spike rate and striatal BDNF level. This research showed that L-T4 prevented the disruption of motor activity and cognitive deficiencies induced by 3-NP. The beneficial effects of L-T4 may be due to an increase in the concentration of BDNF and enhancement of the spike rate in the striatum.