In this experimental investigation, the effect of TiO2 nanoaerosol on the forced convective heat transfer in a pipe flow is investigated. The experiments are conducted at various particle mass fractions (0.005, 0.01, and 0.05), Reynolds numbers (1600, 2100, and 2600), and heat inputs (30, 60, and 90 W). At these operating conditions the Nusselt number, aerosol heat transfer coefficient, and temperature distribution are recorded to analyze the heat transfer performance of the TiO2 nanoaerosol. In this regard, the maximum heat transfer enhancement of the TiO2 nanoaerosol is monitored at the peak operating conditions. The enhancement of the Nusselt number value for the particle mass fraction of 0.05 is reported to be 31.88 ± 0.51%, 14.77 ± 0.63%, and 17.34 ± 0.66% compared to the particle mass fraction of 0.005 at the maximum nanoaerosol Reynolds number of 2600 for 30, 60, and 90 W heat inputs. Simultaneously, the influence of Reynolds numbers and particle mass fractions on the pressure drop of the TiO2 nanoaerosol is studied. The friction factor, viscosity of nanoaerosol, nanoparticles agglomeration, and the Brownian motion of the nanoparticles contributed to the enhancement of the pressure drop. For all particle mass fractions, the average pressure drop is 183% higher at the Reynolds number (2600). While increasing the particle mass fraction causes the pressure drop to increase by 9 times at the constant Reynolds number.