English-language Journals Research Articles

The urban in ecology: a quantitative textual analysis of the scientific literature over a century

Many authors have described ‘urban ecology’ as a subfield of ecology that emerged in the 1990s and has expanded exponentially. We propose to take a step further and analyse the expansion of the ‘urban’ in ecology with a novel quantitative approach, with the aim to better understand the relationship between ecology and the urban. Previous quantitative assessments of the urban in ecology have focused on short to medium time spans (5 to 40 years) and on research coined as ‘urban ecology’, and have rarely considered the content of publications (e.g., vocabulary and topics) using quantitative methods. In this paper, we conduct a bibliometric assessment and an in-depth quantitative textual data analysis of a corpus of 960 articles published from 1922 to 2018 in 10 leading English-language journals in ecology and conservation biology. We address the following questions: (1) When and how have urban environments been integrated into ecological research during the past century? (2) What urban research topics have been investigated in ecology during the same period? (3) How have these research topics changed through time? Our results show that the urban was never entirely absent from publications in ecology. The quantitative analyses highlight three turning points (1970s, 1990s and 2000s) in the relationship between ecology and the urban. Moreover, they help visualize the shift from particularly scattered publications at the beginning of the period to publications characterized by a more homogeneous vocabulary, reflecting the stabilization of a research field focused on the urban in ecology.

Dexmedetomidine as Adjunctive Therapy for the Treatment of Alcohol Withdrawal Syndrome: A Systematic Review and Meta-Analysis.

Alcohol withdrawal syndrome (AWS) is defined as the cessation or reduction in heavy and prolonged alcohol use within several hours to a few days of cessation. The recommended first-line therapy for AWS ranging from mild to severe or complicated remains benzodiazepines; in cases where benzodiazepines are not adequate in controlling persistent autonomic hyperactivity or anxiety, dexmedetomidine could be utilized. The possible advantage of dexmedetomidine compared to benzodiazepines is that it does not cause respiratory depression, thus reducing the risk of intubation and hospitalization in the ICUs, with the potential reduction in healthcare costs. The purpose of this systematic review and meta-analysis (PROSPERO CRD42018084370) is to evaluate the effectiveness and safety of dexmedetomidine as adjunctive therapy to the standard of care for the treatment of AWS. We retrieved literature from PubMed, EMBASE, and CENTRAL until 10 January 2024. Eligible studies were both randomized trials and nonrandomised studies with a control group, published in the English language and peer-reviewed journals. The primary outcome was tracheal intubation; secondary outcomes were (i) bradycardia and (ii) hypotension. A total of 3585 papers were retrieved: 2635 from EMBASE, 930 from Medline, and 20 from CENTRAL. After eliminating duplicates, 2960 papers were screened by title and abstract; 75 out of the 2960 papers were read in full text. The qualitative synthesis included nine of all manuscripts read in full text. The quantitative synthesis included eight studies for the primary outcome (tracheal intubation), seven for the secondary outcome bradycardia, and six for the secondary outcome hypotension. The meta-analysis showed that Dexmedetomidine, as adjunctive therapy, is not more effective than standard therapy in reducing the risk of tracheal intubation in AWS [RR: 0.57, 95% CI: 0.25-1.3, p = 0.15]. It also appears to be less safe than sedative therapy as it significantly increases the risk of bradycardia [RR: 2.68, 95% CI: 1.79-4.16, p = 0.0016]. Hypotension was not significantly different in patients who received dexmedetomidine [RR: 1.5, 95% CI: 0.69-3.49, p = 0.21].

Clinical tools to assess posture in children with cerebral palsy: A systematic review

Objectives: The goal of this comprehensive evaluation of the literature is to evaluate the methodological quality of the tools available for measuring a child’s posture in relation to cerebral palsy (CP) in accordance with the consensus-based criteria for selection of health measurement instruments (COSMIN) criteria and checklist. Materials and Methods: The following inclusion criteria were applied while screening studies found in the PubMed, ScienceDirect, Web of Science, and Scopus databases to determine their eligibility: (1) Clinical examinations of the posture of children with CP; (2) age of 3 years or more at all gross motor function classification system levels; (3) posture evaluation measures described; (4) statistics on responsiveness, validity, and reliability for children with CP; and (5) published in peer-reviewed English-language journals. Data on study features, tool or scale characteristics, and study outcomes were evaluated and discussed. The “quality of research” was evaluated using the COSMIN. Results: Seven tools were found and included in this study out of 349,928 studies. Of these, three were observational measurements and four were instruments. The quality of the studies was very good in 40%, adequate in another 40%, and inadequate in the rest of the 20% studies. The evidence’s level of quality for the posture assessment tool’s measurement quality ranged from very low to low. However, none of the tools evaluated every COSMIN-recommended property. There was a lack of evidence about these measures’ responsiveness. Conclusion: Research on the measuring quality of tools used to evaluate posture in children with CP is scarce and of low quality. In accordance with the COSMIN guidelines, additional studies are required. The PROSPERO database has this review registered under the number CRD42022333121.

Evaluating the Efficacy of Psycho-Behavioral Interventions for Cardiovascular Risk among People Living with HIV: A Systematic Review and Meta-Synthesis of Randomized Controlled Trials.

People with HIV (PWH) are disproportionately affected by cardiovascular disease (CVD). Psycho-behavioral therapies are capable of targeting the pathophysiology underlying HIV-CVD comorbidity. This study synthesized findings from randomized controlled trials (RCTs) of psycho-behavioral therapies for reducing CVD risk among PWH following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Inclusion criteria were: (1) utilized an RCT design, (2) evaluated a cognitive-behavioral or mindfulness-based therapy, (3) sampled adults (age ≥18 years) with HIV, (4) measured a behavioral (e.g., diet) or biological (e.g., immune functioning) CVD risk factor, and (5) published in an English-language peer-reviewed journal. Electronic searches were conducted in six databases (e.g., MEDLINE) using controlled vocabulary and free-text synonyms for HIV, psycho-behavioral therapy, and CVD risk. Data were independently extracted with consensus reached. Outcomes were immune activation, tobacco-smoking, stress, inflammation, and physical activity from 33 studies. There were stronger effects for psycho-behavioral interventions compared to controls on CD4 (Hedge's g=0.262, 95% Confidence Interval [CI]=0.127, 0.396) and tobacco-smoking abstinence (Hedge's g=0.537, 95% CI=0.215, 0.86). There were no differences or insufficient data for stress, inflammation, or physical activity. No eligible studies examined psycho-behavioral interventions on blood pressure, lipids, or weight in PWH. There is increasing importance to further invest in broader CVD risk reduction effort for PWH that include psycho-behavioral intervention strategies.

Breast Cancer Screening among African Immigrants in the United States: An Integrative Review of Barriers, Facilitators, and Interventions.

The purpose of this review was to synthesize the available literature on breast cancer-screening barriers, facilitators, and interventions among U.S. African immigrants. Following the integrative review framework and PRISMA guidelines for reporting systemic reviews, five electronic databases were searched: PubMed, CINAHL, PsycINFO, Medline, and Google Scholar. Studies were included if they were published in English language journals after 1 January 2000 and reported data on breast cancer-screening barriers, facilitators, or interventions among U.S. African immigrants. Barriers and facilitators reported by studies were descriptively examined and synthesized by two authors and classified as aligning with one of the three levels of influences based on the social-ecological model (intrapersonal, interpersonal, and community). Interventions promoting breast cancer screening were narratively summarized. Search procedures retrieved 1011 articles, with 12 meeting the criteria for inclusion in the review (6 qualitative and 6 quantitative). Intrapersonal barriers included limited awareness, fear of pain, language barriers, health concerns, transportation issues, costs, and negative past experiences. Interpersonal barriers involved modesty, spiritual beliefs, and lack of support, while community-level barriers included provider and healthcare-system challenges. Regarding facilitators, past screening experiences and health insurance were the most commonly reported intrapersonal facilitators. The only interpersonal facilitator identified was observing other women experience a breast cancer diagnosis and undergo treatment. Community-level facilitators included appointment reminders, scheduling assistance, culturally congruent interpreters, transportation to screening facilities, and patient navigators. Three articles reported outcomes of breast cancer-screening interventions. All three were pilot studies and reported increased knowledge and attitudes regarding breast cancer screening following the respective interventions. One study examined the uptake of breast cancer screening following the intervention, with results indicating an increase in screening. Findings provide a comprehensive synthesis of factors influencing breast cancer screening among African immigrants and highlight the need for future research on the topic. This review was registered with Prospero (CRD42024502826) before the initiation of search procedures.

Advancements in mobile antenna design: A comprehensive literature review

This study reviews the literature on antenna design in mobile applications, analyzing research, theses, and academic papers to summarize current developments, identify gaps, and suggest future research lines. The review aims to compile the most recent findings on mobile antenna design from respected English-language journals. The study analyzes forty articles discussing both advanced and traditional antenna designs, focusing on efficiency, noise reduction, SAR compliance, size restrictions, polarization, and gain. It emphasizes the importance of innovation and multidisciplinary methods to meet the changing needs of the global communication network. The review uses keywords such as "Antenna," "Antenna Design," "Mobile Antenna," and "Mobile Antenna Design" to find relevant studies across IEEE Xplore, Scopus, Web of Science, and Google Scholar.

Meditation modalities for ADHD in minority pediatric populations in the USA: a scoping review.

Roughly 10% of children aged 3 -17 in the USA are diagnosed with attention-deficit hyperactivity disorder (ADHD), and minorities are less likely to initiate common pharmacologic treatment. We conducted a review of the literature to examine meditation as a safe, effective, and low-cost alternative. We searched PubMed and other journals using "meditation," "mindfulness," "minority," related keywords, and relevant MeSH terms. Eligible studies involved racial/ethnic minorities in the USA, reported quantitative psychosocial outcomes, and were published in a peer-reviewed, English-language journal. Out of 119 "hits," 111 were eliminated as duplicates or were not relevant. A full-text review of the remaining eight revealed that none fully met our eligibility criteria. Besides the obvious lack of studies, those reviewed reported incomplete demographic and clinical data. They also employed different and inconsistent research methodologies, interventions and modalities, and statistical analyses. This hindered understanding exactly which populations may benefit from meditation, and for which specific symptoms. We recommend a socio-ecological model in examining intervention modalities, especially in the context of intrapersonal, interpersonal, organizational, environmental, and policy domains. We also suggest the possible inclusion of research older than 10 years, conducted outside of the USA, on minority and non-minority populations, for supplementary and confirmatory data. We advocate for consistency in study design and data collection, which would help align research conducted in different countries. Searches should also include variations of meditation such as "mindfulness" and "guided imagery," and associated symptoms and comorbidities of ADHD, including "learning disorder" and "behavioral problems."

QUANTIFYING THE EVOLUTION OF IT AUDIT AND CONTROL PRACTICES: A BIBLIOMETRIC APPROACH

This research conducts a comprehensive review spanning nine years of literature on IT audit and control practices. Utilizing bibliometric and content analyses, it examines 88 articles from English-language journals indexed in the Web of Science (WOS) database. In this field, the United States emerges as the dominant contributor and recipient of citations. We note the frequent publication and citation rates of key journals like the Journal of Information Systems, MIS Quarterly, and Accounting Review, featuring prominent authors like J.F. Brazel and Tarafdar M. The analysis underscores increasing interest in topics such as IT audit and governance, particularly from 2010 to 2024. However, the study’s reliance on the WOS core collection may restrict its applicability beyond this specific dataset.

Research integrity in Instructions for Authors in Japanese medical journals using ICMJE Recommendations: A descriptive literature study.

The International Committee of Medical Journal Editors (ICMJE) has published Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals. These provide a global standard for writing and editing medical articles, including research integrity. However, no study has examined the research integrity-related content of Japanese medical journals' Instructions for Authors. We therefore compared research integrity content in ICMJE member journals with those in the English- and Japanese-language journals of the Japanese Association of Medical Sciences (JAMS). This was a descriptive literature study. We obtained Instructions for Authors from English- and Japanese-language journals listed on the JAMS website and the ICMJE member journals listed on the ICMJE website as of September 1, 2021. We compared the presence of 20 topics (19 in the ICMJE Recommendations plus compliance with ICMJE) in the Instructions for Authors, and analyzed the content of the conflict of interest disclosure. We evaluated 12 ICMJE member journals, and 82 English-language and 99 Japanese-language subcommittee journals. The median number of topics covered was 10.5 for ICMJE member journals, 10 for English-language journals, and three for Japanese-language journals. Compliance with ICMJE was mentioned by 10 (83%) ICMJE member journals, 75 (91%) English-language journals, and 29 (29%) Japanese-language journals. The ICMJE Conflicts of Interest Disclosure Form was requested by seven (64%) ICMJE member journals, 15 (18%) English-language journals, and one (1%) Japanese-language journal. Although the topics in the JAMS English-language journals resembled those in the ICMJE member journals, the median value of ICMJE-related topic inclusion was approximately one-third lower in JAMS Japanese-language journals than in ICMJE member journals. It is hoped that Japanese-language journals whose conflict of interest disclosure policies differ from ICMJE standards will adopt international standards to deter misconduct and ensure publication quality.

Examining the Drivers to Support Improved Construction and Demolition Waste Management for a Circular Economy: A Comprehensive Review Using a Systematic Approach

With the rapid pace of global urbanisation, construction demolition waste (CDW) constitutes roughly 36% of the total solid waste deposited in landfill sites worldwide, thereby posing a significant challenge to the sustainability of the construction industry. To address this issue, circular economy strategies are proposed as a solution. This paper systematically analyses 55 research articles published in leading peer-reviewed English-language scholarly journals over the past decade. It aims to identify and categorise drivers for enhanced CDW management by synthesising findings from previous research to support the principles of a circular economy. Utilising a PESTLE model for classification and analysis provides valuable insights into disparities and distinctions among categories, regions, and countries. The resulting analysis yields valuable insights into enablers and trends, with the aim of making a substantial contribution to mitigating the impact of construction activities and thus fostering the establishment of an efficient circular economy within the sector.

Establishing an Intravesical Doublet Chemotherapy Clinic for Nonmuscle-Invasive Bladder Cancer Patients.

Intravesical sequential doublet chemotherapy (SDC) is being used increasingly as a rescue treatment for nonmuscle-invasive bladder cancer failing bacillus Calmette-Guérin (BCG), as single-agent chemotherapies are less effective, especially for carcinoma in situ. Considering the current BCG shortage, intravesical SDC also provides an efficacious alternative to BCG. Our aim is to detail the implementation to assist with establishing an efficient and practical intravesical SDC clinic for urologic practice. We searched PubMed for published studies with the Medical Subject Heading of "intravesical chemotherapy" and "non-muscle invasive bladder cancer." The search was limited to English-language journals and full papers only. The initial search resulted in 260 articles, of which 20 relevant studies were selected. Five important processes were identified in the successful and efficient administration of intravesical SDC: (1) patient preparation, (2) medication procurement, (3) medication administration, (4) medication immediate aftermath, and (5) patient instruction and education. Safety precautions should be taken when handling each chemotherapy drug. A clinical pharmacist may be required for drug preparation. An important step in providing intravesical SDC is to use a closed system for the instillation of the chemo-solution. A special protocol should be adopted for every drug with its proper dwell time. The induction course consists of weekly instillation for 6 weeks. If an initial response is noted, maintenance therapy is recommended, typically monthly for 24 months. Successful intravesical SDC clinics necessitate appropriate patient selection, standardized workflow procedures, patient education, and good communication between the urologist, clinical pharmacists, and oncology nurses.

Analyzing research trends after the international journal transition of the Korean Journal of Medical Education: using topic modeling techniques.

This study aimed to analyze the research trends of the Korean Journal of Medical Education (KJME) since it became an English-language journal. A total of 274 articles published in KJME from 2016 to 2023 were analyzed. All article types were included in the analysis. NetMiner ver. 4.0 (Cyram Inc., Korea) was used for the main keyword and topic modeling analysis. Of the 274 articles, 170 (62%) and 104 (38%) were by domestic and international authors, respectively. The main keywords with high frequency were "students," "learning," "experience," "pandemic," and "perception." Three topics were derived using topic matching analysis: "residents' perception and attitude of the pandemic," "assessment of learning and achievement," and "learning experiences in the pandemic." Since the shift to English-language journals, medical education research has witnessed an increase in the number of articles published by international authors. Research on postgraduate education has increased. Research topics are relevant to situations such as the coronavirus disease 2019 pandemic. These findings can help researchers select research topics and encourage them to submit their research to the journal.

Challenges and opportunities in the uptake of simulation in healthcare education in the developing world: a scoping review.

Simulation is increasingly being adopted by healthcare educators throughout the developed world as it offers a safe environment to practice skills. While there is literature on learning via simulation in healthcare in the developed world, more studies are required to investigate the factors influencing this approach in the developing world. This scoping review highlights the key factors that act as deterrents as well as encouragement to the uptake of simulation as a teaching methodology in healthcare education in developing countries. The MEDLINE (via OVID, using keywords and MeSH in OVID), and PubMed (via NCBI using MeSH), and CINAHL databases were searched between January 2000 and January 2024 for research articles published in peer reviewed English language journals using a combination of keywords. A total of 48 articles were included in the final analysis. Challenges and opportunities were divided into professional, academic, and resource-based factors, and their individual sub-themes. The main challenges reported were the lack of a contextual curriculum, content heavy curricula, dearth of trained simulationists and cost of simulators. Performance anxiety was an important challenge reported by both trainers and trainees. Main opportunities were an interest in adopting simulation-based education from both trainers and trainees, and the opportunity to improve patient safety and quality of education. Other findings were that academic leadership and faculty show interest and urgency to adopt simulation in curricula and allocate funds for this. Facilitators need to be provided with protected time to become simulationists. Local manufacturers need to be sourced for simulators, and transfer of technology and expertise needs to be negotiated. Simulation needs to be looked at from the lens of not only education, but more importantly of patient safety in developing countries to allow simulation-based education to be mainstreamed in health professions education in low- and middle-income contexts.

Theoretical Perspectives Underpinning Research on the Physician-Patient Relationship in a Digital Health Practice: Scoping Review.

The advent of digital health technologies has transformed the landscape of health care, influencing the dynamics of the physician-patient relationship. Although these technologies offer potential benefits, they also introduce challenges and complexities that require ethical consideration. This scoping review aims to investigate the effects of digital health technologies, such as digital messaging, telemedicine, and electronic health records, on the physician-patient relationship. To understand the complex consequences of these tools within health care, it contrasts the findings of studies that use various theoretical frameworks and concepts with studies grounded in relational ethics. Using the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) guidelines, we conducted a scoping review. Data were retrieved through keyword searches on MEDLINE/PubMed, Embase, IEEE Xplore, and Cochrane. We screened 427 original peer-reviewed research papers published in English-language journals between 2010 and 2021. A total of 73 papers were assessed for eligibility, and 10 of these were included in the review. The data were summarized through a narrative synthesis of the findings. Digital health technologies enhance communication, improve health care delivery efficiency, and empower patients, leading to shifts in power dynamics in the physician-patient relationship. They also potentially reinforce inequities in health care access due to variations in technology literacy among patients and lead to decreases in patient satisfaction due to the impersonal nature of digital interactions. Studies applying a relational ethics framework have revealed the nuanced impacts of digital health technologies on the physician-patient relationship, highlighting shifts toward more collaborative and reciprocal care. These studies have also explored transitions from traditional hierarchical relationships to mutual engagement, capturing the complexities of power dynamics and vulnerabilities. Other theoretical frameworks, such as patient-centered care, and concepts, such as patient empowerment, were also valuable for understanding these interactions in the context of digital health. The shift from hierarchical to collaborative models in the physician-patient relationship not only underscores the empowering potential of digital tools but also presents new challenges and reinforces existing ones. Along with applications for various theoretical frameworks and concepts, this review highlights the unique comprehensiveness of a relational ethics perspective, which could provide a more nuanced understanding of trust, empathy, and power dynamics in the context of digital health. The adoption of relational ethics in empirical research may offer richer insights into the real-life complexities of the physician-patient relationship, as mediated by digital technologies.

Influence of Socioeconomic Factors on Access to Digital Resources for Education

Digital resources in education encompass a wide array of technological tools, online platforms, and digital content utilized to facilitate and enhance the learning process. They serve as invaluable supplements to traditional teaching methods, offering dynamic and diverse ways to impart knowledge, encourage engagement, and foster skill development among learners. This systematic review critically examines the influence of socioeconomic factors on access to digital resources for education by analyzing studies published between 2017 and 2024. The inclusion criteria prioritized empirical studies in English-language peer-reviewed journals or reputable conference proceedings, utilizing various research designs. The review involved a thorough search across databases like JSTOR, APA PsycNet, Wiley Online Library, ERIC, and Google Scholar. The study's analysis identified key themes, highlighting the profound influence of socioeconomic factors on technology access, engagement, and academic outcomes. The recurring theme of the digital divide emphasized disparities in device ownership, internet connectivity, and effective technology utilization. The nuanced exploration of parenting approaches, gender dynamics, and educational contexts added depth to understanding these influences. This study found the necessity for a holistic approach in educational planning, considering socioeconomic, cultural, and educational factors to effectively address challenges and disparities, ultimately fostering equitable access to digital resources in education.

Utilization for Non-Communicable Diseases Management in Southeast Asia

Non-communicable diseases (NCDs) are still a morbidity and mortality problem in Southeast Asia. However, NCD in Southeast Asia still needs to be handled faster. WHO recommends the use of digital in treating NCDs in Southeast Asia. Therefore, this literature review study aims to describe how mHealth is utilized to overcome the problem of NCDs in Southeast Asian countries. The author collected articles using Google Scholar and Proquest, which were published in 2019-2023. The focus of the search was articles published in English-language Research Journals. Researchers used advanced search with the keywords NCD, Non-communicable diseases, mHealth, Mobile Health, Nursing, and Health Promotion. Keywords are combined using Boolean and/or the online database that the researcher chose. Articles that have been filtered are filtered again by selecting research locations in Southeast Asian countries. Ten articles obtained came from research in Southeast Asian countries Indonesia (n=4), Malaysia (n=1), Singapore (n=1), Vietnam (n=1), Thailand (1), Cambodia (n=1), Philippines (n=1). All articles discussed the use of mHealth for NCD management in their countries and aimed to determine the barriers (n=3), feasibility (n=1), effectiveness (n=2), impact (n=2), potential (n=1), perception (n=1), and perspective (n=1) of service providers, as well as the experience of using mHealth in remote areas (n=1). It can be concluded that mHealth can be used for independent screening for PTM, providing education about NCDs, and can be applied in rural areas as a comprehensive effort to handle NCDs.

344 The World Neurosurgery Global Champions Program: First-year Experience of a Model Initiative for Reducing Disparities in Global Neurosurgical Literature

INTRODUCTION: Most surgical journals are published in English, representing a challenge for individuals from non-Anglophone countries and contributing to disparities in research globally. METHODS: The GCP was advertised via the journal website and social media. Applicants were selected to be a reviewer for the GCP if they demonstrated English proficiency. Authors received information about the program if their article was rejected on the basis of poor English language. The workflow is shown.The demographics of GCP members and characteristics and outcomes of articles edited by the GCP during its first year were reviewed. Surveys of GCP members and authors who used the service were conducted. RESULTS: Twenty-one individuals became part of the GCP, representing 8 countries and 16 languages apart from English. A total of 380 manuscripts were peer-reviewed and a final decision given by the editor-in-chief to have potentially worthwhile content but rejected due to poor language. The authors of these manuscripts were informed of the existence of this language assistance program. Forty-nine articles (12.9%) were edited by the GCP in 41.6 ± 22.8 days. Of 40 articles resubmitted to World Neurosurgery, 24 (60.0%) were accepted. GCP members and authors understood the purpose and workflow of the program and recognized improvements in article quality and the probability of acceptance through their participation. CONCLUSIONS: The World Neurosurgery Global Champions Program mitigated a critical barrier to publication in an English language journal for authors from non-Anglophone countries and promoted research equity by providing a free, largely medical student and trainee operated, English language editing service. This model or a similar service can be replicated by other journals.

SOCIOLINGUISTIC COMPETENCIES IN ORAL TRANSLATION

Translating is sociolinguistic activity. We can define sociolinguistics as the study of language in relation to society, and this is how we shall be taking the term in this book. Sociolinguistics has become a recognized part of most courses at university level on 'linguistics' or 'language', and is indeed one of the main growth points in the study of language, from the point of view of both teaching and research. There are now major English-language journals devoted to research publications) and a number of introductory textbooks, apart from the present one.

A systematic review of post-operative infections in pediatric ventriculoperitoneal shunt cases

Background. Hydrocephalus is a prevalent condition in children, affecting both developed and developing countries. Neurosurgical interventions such as ventriculoperitoneal shunts are common, but are associated with a high risk of complications, including infections, which can lead to additional issues and costs. This study aims to review the incidence of infection in pediatric patients before and after ventriculoperitoneal shunt placement, in order to address this issue. Methods. A standard process of analyzing scientific questions using the Population, Intervention, Control, and Outcome (PICO) method was used to develop a protocol for searching research articles in online databases such as PubMed, Cochrane, POPLINE, and ScienceDirect. The articles selected for inclusion in this study met the following criteria: 1) described interventional ventriculoperitoneal shunt placement in pediatrics, 2) focused on cases of ventriculoperitoneal shunt complications with a focus on infection, 3) were published within the last 10 years, and 4) were published in English-language journals with peer review standards. Results. Sixteen articles were identified for review. Seven of these articles mentioned surgical or mechanical interventions as a means of preventing infections, while six articles discussed medical treatment for infection prevention. Three articles described the microorganisms found in cerebrospinal fluid. Conclusion. Future studies should focus on the issues related to ventriculoperitoneal shunt complications and interventions related to immunological, neuroendocrine, and biophysical factors to prevent infections, as well as surgical management and medication administration.

Acute rotenone poisoning: A scoping review

ContextRotenone is a toxic chemical found in various plants, including some used as food. Rotenone poisoning can be fatal and there is no antidote. Mechanistically, rotenone inhibits mitochondrial complex I, leading to reduced ATP production, compensatory glycolytic upregulation and secondary lactate production, and oxidative stress. Our literature review examined acute rotenone poisoning in humans, including exposure scenarios, clinical presentations, and treatments. MethodsWe searched five databases for relevant literature from database inception through the search date: July 12, 2022, pairing controlled vocabulary and keywords for “rotenone” with terms relating to human exposures and outcomes, such as “ingestion,” “exposure,” and “poisoning.” We included all peer-reviewed reports found using the search terms where the full English text was available. Data abstracted included the number, age, weight, and sex of the exposed person(s), country where exposure happened, exposure scenario, ingestion context, estimated dose, clinical features, whether hospitalization occurred, treatments, and outcomes. ResultsAfter removing non-qualifying sources from 2,631 publications, we identified 11 case reports describing 18 victims, 15 of whom were hospitalized and five died. Most cases occurred in private quarters where victims unknowingly consumed rotenone-containing plants. Vomiting and metabolic acidosis occurred most commonly. Some patients exhibited impaired cardiopulmonary function. Supportive treatment addressed symptoms and included gastric lavage and/or activated charcoal to remove rotenone from the stomach, vasopressors for hypotension, mechanical ventilation for respiratory insufficiency, and sodium bicarbonate for acidosis. Some patients received N-acetylcysteine to counter oxidative stress. ConclusionsRotenone poisoning, though rare, can be fatal. Exposure prevention is impractical since rotenone is found in some plants used as food or pesticides. Cases may be under-diagnosed because symptoms are non-specific and under-reported in English-language journals since most cases occurred in non-English speaking countries. Treatments are supportive. Exploring antioxidant therapy in animal models of rotenone poisoning may be indicated considering rotenone's mechanism of toxicity.