This paper substantiates the necessity of developing an integrated specialized engineering geological approach to the problem of siting toxic waste storage facilities. The fact that the ground stratum of a storage base can serve as a natural geochemical barrier, preventing diffusion of pollutants from the storage into a water-bearing horizon, underlies such an approach. The screening capacity of the ground stratum depends on a number of natural factors that are laid out, estimated, and analyzed in the paper. It is suggested that these results should be reflected on a map of special engineering-geological zoning, on which areas with different conditions of groundwater protection are determined. This permits one to determine storage locations most rationally and to solve a number of problems of environmental protection in the course of the operation of such a facility.