The effect of diesel engine exhaust fouling on heat and mass exchangers for waste heat recovery is investigated. Experiments are conducted for a range of operating conditions relevant to the use of the waste heat from a diesel engine for powering a 2.71 kW capacity absorption heat pump. Thermal resistances of fouling layers as well as their effects on pressure drop are determined, and the underlying mechanisms for deposition and removal are investigated. Fouling layer effects are most severe for the lowest coolant temperatures and 100% generator load. At these conditions, the fouling thermal resistance is approximately 70% of the total resistance, and the ratio of the steady-state pressure drop to the baseline pressure drop is 3.25. Flow induced shear is found to be the primary growth inhibiting mechanism at high exhaust velocities. Results from this study can guide heat exchanger design for a variety of waste heat recovery systems.