Citizen science has become a powerful force for scientific inquiry, providing researchers with access to a vast array of data points while connecting nonscientists to the authentic process of science. This citizen-researcher relationship creates an incredible synergy, allowing for the creation, execution, and analysis of research projects that would otherwise prove impossible in traditional research settings, namely due to the scope of needed human or financial resources (or both). However, citizen-science projects are not without their challenges. For instance, as projects are scaled up, there is concern regarding the rigor and usability of data collected by citizens who are not formally trained in research science. While these concerns are legitimate, we have seen examples of highly successful citizen-science projects from multiple scientific disciplines that have enhanced our collective understanding of science, such as how RNA molecules fold or determining the microbial metagenomic snapshot of an entire public transportation system. These and other emerging citizen-science projects show how improved protocols for reliable, large-scale science can realize both an improvement of scientific understanding for the general public and novel views of the world around us.