Abstract Art includes performing arts, visual arts, literature, culture, and online/digital products. Its interventions are multimodal, combining a variety of activities, such as evoking emotions, emotional and cognitive stimulation, and imagination. Depending on the type of art, they may also involve social interaction, physical activity and communication. There is a large body of research suggesting that art engagement can enhance different dimensions of mental well-being (eudaimonic well-being, life satisfaction, evaluative well - and positive emotions). Some or all of these benefits have been found in individuals who participate in art activities. Based on these findings, art on prescription has been used in some European countries, including the United Kingdom, and Scandinavian countries. Art on prescription is mostly delivered in partnership with art organizations. The aim of this talk is give an overview on art on prescription in different countries in Europe and enhance understanding of the mechanism for whom art on prescription is a promising intervention in the field of mental health. Building on the mapping and review of reviews challenges of art interventions will be discussed such as study design or evaluating effectiveness and identifying population groups for whom art interventions work best.