Immersogeometric analysis (IMGA) is a geometrically flexible method that enables one to perform multiphysics analysis directly using complex computer-aided design (CAD) models. While the IMGA approach is well-studied and has a remarkable advantage over traditional CFD, IMGA still requires a well-defined B-rep model to represent the geometry. Obtaining such a model can sometimes be equally as challenging as creating a body-fitted mesh. To address this issue, we develop a novel IMGA approach for the simulation of incompressible and compressible flows around complex geometries represented by point clouds in this work. The point cloud representation of geometries is a direct method for digitally acquiring geometric information using LiDAR scanners, optical scanners, or other passive methods such as multi-view stereo images. The point cloud object’s geometry is represented using a set of unstructured points in the Euclidean space with (possible) orientation information in the form of surface normals. Due to the absence of topological information in the point cloud model, there are no guarantees for the geometric representation to be watertight or 2-manifold or to have consistent normals. To perform IMGA directly using point cloud geometries, we first develop a method for estimating the inside–outside information and the surface normals directly from the point cloud. We also propose a method to compute the Jacobian determinant for the surface integration (over the point cloud) necessary for the weak enforcement of Dirichlet boundary conditions. We validate these geometric estimation methods by comparing the geometric quantities computed from the point cloud with those obtained from analytical geometry and tessellated CAD models. In this work, we also develop thermal IMGA to simulate heat transfer in the presence of flow over complex geometries. The proposed framework is tested for a wide range of Reynolds and Mach numbers on benchmark problems of geometries represented by point clouds, showing the robustness and accuracy of the method. Finally, we demonstrate the applicability of our approach by performing IMGA on large industrial-scale construction machinery represented using a point cloud of more than 12 million points.