ABSTRACT Single crystals L– Histidine Cadmium Bromide (LHCdBr) have been grown successfully by solution growth method. Transparent crystal was obtained in the period of 2 weeks. The single crystal X-ray diffraction shows that the crystal is triclinic in structure. Powder X-ray diffraction analysis was carried to identify the intense peak. The various functional groups present were confirmed by Fourier Transform Infrared spectroscopy. By using Energy Dispersive X-ray Spectroscopy studies presence of elemental composition was confirmed. From the optical studies the cut-off length is found to be 315 nm. The mechanical properties of the LHCdBr crystal have been analysed. The dielectric study was carried out and reported in this paper. By the Kurtz powder method the second harmonic generation was confirmed and it is 0.9 times greater than that of KDP crystal. LHCdBr shows good antibacterial activity against various standard bacterial strains (E. coli, Shigella flexneri, Salmonella typhi and Staphylococcus aureus).