Energetic Radiation Research Articles

Development of a Daily Databank of Solar Radiation Components for Moroccan Territory

The main objective of this work is to create a daily updated database that includes all components of solar radiation, either energetic or spectral radiation. This will lead us to quantify the Moroccan solar potential and to determine the dimensions of all types of solar thermal and photovoltaic systems. Consequently, the obtained database will be the fundamental support for engineers, designers, and all organizations interested in developing solar systems, in different regions throughout Morocco. It will also be a basic tool for researchers in modelling and simulating the new solar systems. Firstly, we used one year’s worth of measurements of the different components of the solar radiation, provided by the National Meteorological Department, to establish the extrapolation equations between the global radiation at the reference site and the global radiation of twenty-eight other sites. As well as with the same measurements, we developed the correlation equations between the global solar radiation and the other solar radiation components. Secondly, from ten years of Fez station’s daily global radiation measurements and through the extrapolation equations, we were able to estimate the global radiation of all Moroccan cities. Then, by using the obtained global radiation data and the correlation equations, we predicted the other components of solar radiation. Subsequently, with a new measurement campaign carried out on several sites, we validated the estimation models by using the usual statistical indicators. In addition, we compared our results with those obtained by other estimation models. The resulting differences for each solar component display the advantage of our model with errors under 6%. To facilitate the use of our results, we compiled them into maps representing the spread of solar radiation across Morocco.

Evaluation and application of gas chromatography - vacuum ultraviolet spectroscopy for drug- and explosive precursors and examination of non-negative matrix factorization for deconvolution.

Since the introduction of a benchtop vacuum ultraviolet (VUV) absorption spectroscope with an increased wavelength range towards to the high energetic ultraviolet radiation, gas chromatography coupled to VUV has been proven a powerful tool in several fields of application such as petroleomics, permanent gas analytic, pesticide analytic and many more. In this study, the potential of GC-VUV for investigations was examined, focusing on drug- and explosive precursors as well as chemical warfare simulants. The ability of VUV absorption spectra to differentiate isomers is presented, among others for nitroaromatics. In addition, the limit of detection for target compounds was determined to 0.7 ng absolute on column. Furthermore, non-negative matrix factorization (NMF) was successfully implemented as alternative deconvolution approach and evaluated for the deconvolution of unknown substances. In comparison, the spectral library-based deconvolution was applied to a standard mixture and a simulated case study. The results reveal that the NMF is a useful additional tool for deconvolution because, unlike library-based deconvolution, it allows to investigate unknown substances as well.

Proton and electron irradiation effects on multi-walled carbon nanotubes

In the present study, interaction of electron and proton irradiation on multi-wall carbon nanotubes (MWCNTs) were investigated. The pelletized samples were subjected to different doses (0.6 × 1013 p/cm2; 1.8 × 1013 p/cm2; 3.6 × 1013 p/cm2) of 15 MeV energetic proton irradiation. Also, effect of different energies (6 MeV; 9 MeV; 12 MeV; 15 MeV) of electron irradiation in 1000 mGy were investigated. Raman spectroscopy, x-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM) and scanning electron microscopy (SEM) were performed to elucidate the optical, structural, morphological and chemical changes of the samples under irradiation. According to the Raman and XPS results, in case of irradiation with proton, increasing trend in the formation of defects has been concluded for all different fluences of proton irradiation. Especially imperfection rate has reached highest value for the sample irradiated with 0.6 × 1013 p/cm2 proton fluence. The rate of increase in defect formation is 10.18% compared to non-irradiated sample. The reduction in increasing of defect rate with increasing fluence indicates that the mechanisms of defect removal are not predominant, but increase. Increasing trend of the structural imperfections have occurred with the irradiation in electrons (except for 6 MeV energetic electrons). Especially, in the case of irradiation with 15 MeV energized electrons, the defect rate is the highest with 8.5% compared to the non-irradiated sample. Structural distortions manifest themselves as bending, penetration, fractures and black spots in the TEM and SEM figures.

Influence of mono energetic gamma radiation on structural and electrical properties of TiO2 thin film coated on p-type porous silicon

Titanium dioxide thin film was coated on p-type porous silicon by sol–gel spin coating method. The prepared samples were irradiated by the mono-energetic gamma radiation at Auto-irradiation facility with the Cesium-137 for the Gamma dose range from 100 to 1000 mSv. Gamma irradiated samples revealed that the physical changes of titanium oxide/porous silicon layer found to be varying with increasing gamma dose. The irradiated titanium oxide/porous silicon layer were investigated by scanning electron microscopy, X-ray diffraction, Fourier transform infra-red, Photoluminescence and I–V characteristics studies. The surface morphology of the irradiated titanium oxide/porous silicon layer has shown deformation with increasing gamma dose. The X-ray diffraction patterns of titanium oxide/porous silicon layer after irradiation revealed changes in crystallite size, dislocation density, strain and phase content. These changes in anatase (004) are linear with gamma dose than the rutile (310) of TiO2-PSi. Fourier transform infra-red spectrums of the irradiated samples showed an increase in intensity of vibration modes with the increase of the radiation dose. Photoluminescence peaks are found to be in the range of 330 to 360 nm for all the irradiated samples and the intensity of Photoluminescence peak increased for the irradiated samples with increasing gamma dose. I–V Characteristics revealed that the electrical conductivity of irradiated samples increased linearly with gamma dose. The linear changes in electrical property of titanium oxide/porous silicon under the influence of mono-energetic gamma photons gives a positive indication that it can be further studied for the development of radiation sensor for applications in nuclear field.

Probing heavy ion radiation effects in silicon carbide (SiC) via 3D integrated multimode vibrating diaphragms

We report on the measurement and analysis of energetic heavy ion radiation effects on the mechanical properties of silicon carbide (SiC) crystals, by exploiting a vertical stack of micromachined vibrating SiC thin diaphragms integrated in a three-dimensional (3D) fashion. The diaphragms are 1 mm × 1 mm in lateral dimensions and 2 μm in thickness, vibrating at their multiple flexural modes in the range of 200 to 800 kHz. Upon 10.25 MeV oxygen ion irradiation, the 4 devices in the 3D stack exhibit saliently different changes in their multimode resonance frequencies. The device that is intended to capture most ions shows the largest frequency downshifts (∼6.6%–11.3%), corresponding to the extracted tension release from 382 MPa to 306 MPa, which can be explained by the maximum displacement damage in this device. The design of 3D integration not only scientifically enables probing different radiation effects in multiple devices simultaneously with clear controls but also economically evades very expensive, repetitive tests on individual devices, thus proving to be a powerful platform for analyzing and understanding radiation damage in micro/nanoelectromechanical systems and other micro/nanosystems.

Evolution of radiation defects in NPN bipolar junction transistors irradiated by 3 MeV protons

In space, energetic proton irradiation produces both ionization and displacement damage in semiconductors and devices served in spacecraft. In order to separate the ionization and displacement damage in bipolar junction transistor (BJT), the electrical degradation and radiation-induced defects were studied during 3 MeV proton irradiation and the annealing process. The current gain degradation shows a nonlinear relationship with the increasing fluence during irradiation. It can be deduced that the proton irradiation produces the ionization/displacement combined damage in NPN BJTs. Ionization and displacement-induced defects are measured by deep level transient spectroscopy (DLTS) during the isochronal annealing. During the isochronal annealing, the ionization-induced defects annealed at a relatively low temperature (400 K), while the displacement-induced defects recovered at a higher temperature (higher than 500 K). According to the comparison between the DLTS analysis and current gain recovery, the accepter-like defects (V-O and V2(−/0)) act an important role in irradiated NPN BJTs.

Effect of Electron Irradiation and Operating Voltage on the Deep Dielectric Charging Characteristics of Polyimide

Space Solar Power Station (SSPS) will operate in geosynchronous orbit. Its operating environment is rather complicated, including space plasma, energetic particles radiation, extreme temperature, and cosmic rays. To reduce power loss, SSPS has to apply high-voltage (HV) power generation and transmission technique. Deep dielectric charging will be a major problem in the design of insulation structure in SSPS. In this paper, the hopping conductivity of polyimide was studied. Hopping distance and hopping barrier height were obtained from surface potential decay analysis. Second, a deep dielectric charging model of polyimide under FLUMIC spectrum electron irradiation was established, in which the hopping conductivity parameters were applied. The effects of electron flux enhancement and operating voltage on the charging characteristics were discussed in four cases, i.e., A) suspended-HV; B) HV-suspended; C) grounded-HV; and D) HV-grounded. When the electron flux enhancement increases, the influence on case A is much larger than the other three cases. When the operating voltage increases, the influence on cases A and B is small, whereas the influence on cases C and D increases fast. Thus, when designing the SSPS, the effect of operating voltage and electron flux enhancement on the insulation system must be carefully considered.

Observationally Weak TGFs in the RHESSI Data.

Terrestrial gamma ray flashes (TGFs) are sub‐millisecond bursts of high energetic gamma radiation associated with intracloud flashes in thunderstorms. In this paper we use the simultaneity of lightning detections by World Wide Lightning Location Network to find TGFs in the Reuven Ramaty High Energy Solar Spectroscopic Imager (RHESSI) data that are too faint to be identified by standard search algorithms. A similar approach has been used in an earlier paper, but here we expand the data set to include all years of RHESSI + World Wide Lightning Location Network data and show that there is a population of observationally weak TGFs all the way down to 0.22 of the RHESSI detection threshold (three counts in the detector). One should note that the majority of these are “normal” TGFs that are produced further away from the subsatellite point (and experience a 1/r 2 effect) or produced at higher latitudes with a lower tropoause and thus experience increased atmospheric attenuation. This supports the idea that the TGF production rate is higher than currently reported. We also show that compared to lightning flashes, TGFs are more partial to ocean and coastal regions than over land.

Energetic radiation from thunderclouds: extended particle fluxes directed to Earth’s surface

After introducing spectrometers with the energy threshold of 0.3 MeV the pattern of the thunderstorm ground enhancements (TGEs) observed on Aragats dramatically changed demonstrating multi-hour radiation. In the paper, we analyze comprehensive observations made on different time scales and energy ranges. A new model of TGE is discussed explaining much larger time of particle fluxes from clouds.

A Brief History of Space Climatology: From the Big Bang to the Present

Review of space climatology is presented with a view toward spacecraft electronics applications. The origins and abundances of space radiations are discussed and related to their potential effects. Significant historical developments are summarized leading to the inception of space climatology and into the space era. Energetic particle radiation properties and models of galactic cosmic rays, solar energetic and geomagnetic trapped particles are described. This includes current radiation effects issues that models face today.

Efficient minority carrier detrapping mediating the radiation hardness of triple-cation perovskite solar cells under proton irradiation

Although highly energetic proton irradiation forms localized trap states in triple cation perovskites, solar cells possess exceptional radiation hardness.

A multi-wavelength view of magnetic flaring from PMS stars

Context. Flaring is an ubiquitous manifestation of magnetic activity in low mass stars including, of course, the Sun. Although flares, both from the Sun and from other stars, are most prominently observed in the soft X-ray band, most of the radiated energy is released at optical/UV wavelengths. In spite of decades of investigation, the physics of flares, even solar ones, is not fully understood. Even less is known about magnetic flaring in pre-main sequence (PMS) stars, at least in part because of the lack of suitable multi-wavelength data. This is unfortunate since the energetic radiation from stellar flares, which is routinely observed to be orders of magnitude greater than in solar flares, might have a significant impact on the evolution of circumstellar, planet-forming disks. Aims. We aim at improving our understanding of flares from PMS stars. Our immediate objectives are constraining the relation between flare emission at X-ray, optical, and mid-infrared (mIR) bands, inferring properties of the optically emitting region, and looking for signatures of the interaction between flares and the circumstellar environment, i.e. disks and envelopes. This information might then serve as input for detailed models of the interaction between stellar atmospheres, circumstellar disks and proto-planets. Methods. Observations of a large sample of PMS stars in the NGC 2264 star forming region were obtained in December 2011, simultaneously with three space-borne telescopes, Chandra (X-rays), CoRoT (optical), and Spitzer (mIR), as part of the “Coordinated Synoptic Investigation of NGC 2264” (CSI-NGC 2264). Shorter Chandra and CoRoT observations were also obtained in March 2008. We analyzed the lightcurves obtained during the Chandra observations (∼300 ks and ∼60 ks in 2011 and 2008, respectively), to detect X-ray flares with an optical and/or mIR counterpart. From the three datasets we then estimated basic flare properties, such as emitted energies and peak luminosities. These were then compared to constrain the spectral energy distribution of the flaring emission and the physical conditions of the emitting regions. The properties of flares from stars with and without circumstellar disks were also compared to establish any difference that might be attributed to the presence of disks. Results. Seventy-eight X-ray flares (from 65 stars) with an optical and/or mIR counterpart were detected. The optical emission of flares (both emitted energy and peak flux) is found to correlate well with, and to be significantly larger than, the X-ray emission. The slopes of the correlations suggest that the difference becomes smaller for the most powerful flares. The mIR flare emission seems to be strongly affected by the presence of a circumstellar disk: flares from stars with disks have a stronger mIR emission with respect to stars without disks. This might be attributed to either a cooler temperature of the region emitting both the optical and mIR flux or, perhaps more likely, to the reprocessing of the optical (and X-ray) flare emission by the inner circumstellar disk, providing evidence for flare-induced disk heating.

Effect of x-rays and gamma radiations on the bone mechanical properties: literature review.

The bone auto grafting, isografting, allografting and xenografting are used for defective bone replacement or treatment in almost all living species. The X-ray and Gamma (electromagnetic radiation) sterilization performed on the donor bone graft to prevent toxicity or migration of virus/bacterial infections from donors to reciver. Conversely, X-ray and Gamma radiation deteriorates the bone mechanical properties and bone become more susceptible to fracture. Fracture toughness as well as other mechanical properties of bone change with these radiations. In this literature review the effect of the X-rays and Gamma radiation on bone mechanical properties are discussed. All relevant literature was reviewed. After reviewing the literature only the research relating to the effect of X-rays and Gamma radiations on bone mechanical properties are included. Literature studies showed significant effect of the X-rays and Gamma radiations on the mechanical properties of the bones. In some studies the differences exists on the doses of radiations which were discussed in this study. The high energetic electromagnetic radiation (X-rays and Gamma radiations) changed/modify the collagen network of the bone, which reduced the mechanical properties of bone; however these changes depend on the radiation dose.

Periastron Observations of TeV Gamma-Ray Emission from a Binary System with a 50-year Period

Abstract We report on observations of the pulsar/Be star binary system PSR J2032+4127/MT91 213 in the energy range between and with the Very Energetic Radiation Imaging Telescope Array and Major Atmospheric Gamma Imaging Cherenkov telescope arrays. The binary orbit has a period of approximately 50 years, with the most recent periastron occurring on 2017 November 13. Our observations span from 18 months prior to periastron to one month after. A new point-like gamma-ray source is detected, coincident with the location of PSR J2032+4127/MT91 213. The gamma-ray light curve and spectrum are well characterized over the periastron passage. The flux is variable over at least an order of magnitude, peaking at periastron, thus providing a firm association of the TeV source with the pulsar/Be star system. Observations prior to periastron show a cutoff in the spectrum at an energy around . This result adds a new member to the small population of known TeV binaries, and it identifies only the second source of this class in which the nature and properties of the compact object are firmly established. We compare the gamma-ray results with the light curve measured with the X-ray Telescope on board the Neil Gehrels Swift Observatory and with the predictions of recent theoretical models of the system. We conclude that significant revision of the models is required to explain the details of the emission that we have observed, and we discuss the relationship between the binary system and the overlapping steady extended source, TeV J2032+4130.

Investigating the impact of gamma radiation on structural and optical properties of Eu3+ doped rare-earth hafnate pyrochlore nanocrystals

A proposed method for treating nuclear high level radioactive (NHLW) is to encapsulate it in a matrix made of complex oxide materials, such as pyrochlores with the general formula A2B2O7. Rare-earth hafnate pyrochlores have the potential to advance the current methods of NHLW disposal due to their robust chemical stability in radioactive environments, their high thermal stability, and their natural structural compatibility with radionuclide species. In this study, RE2Hf2O7:Eu3+ (RE = Y, La, Pr, Gd, Er, Lu) nanoparticles synthesized by a molten salt method were exposed to highly energetic gamma-ray irradiation. La2Hf2O7:Eu3+ and Lu2Hf2O7:Eu3+ underwent the order pyrochlore-disorder fluorite structural phase transition after exposure to gamma-ray irradiation. There was a change in the O-Eu charge transfer band (CTB) position as a function of gamma-ray dose. There was no change in the local symmetry of the Eu3+ dopant in Y2Hf2O7, Gd2Hf2O7 and Lu2Hf2O7, but in La2Hf2O7:Eu3+ gamma-ray dose reduced the symmetry around the Eu3+. For Y2Hf2O7:Eu3+ and La2Hf2O7:Eu3+, the lifetime and emission intensity were found to degrade possibly due to creation of gamma ray-induced defects which provides non-radiative pathways. Regarding Gd2Hf2O7:Eu3+, the concentration of oxygen vacancy defects predominated over other defects leading to enhanced emission and lifetime after gamma-ray irradiation. This study is of utmost importance for the design of a robust rare earth hafnate pyrochlore to be used as a nuclear waste host or gamma-ray based scintillator material.

Implementing time resolved electron temperature capability at the NIF using a streak camera.

A new capability at the National Ignition Facility (NIF) has been implemented to measure the temperature of x-ray emitting sources. Although it is designed primarily for Inertial Confinement Fusion (ICF), it can be used for any hot emitting source that is well modeled. The electron temperature (Te) of the hot spot within the core of imploded ICF capsules is an effective indicator of implosion performance. Currently, there are spatially and temporally integrated Te inferences using image plates. A temporally resolved measurement of Te will help elucidate the mechanisms for hot spot heating and cooling such as conduction to fuel, alpha-heating, mix, and radiative losses. To determine the temporally resolved Te of hot spots, specific filters are added to an existing x-ray streak camera "streaked polar instrumentation for diagnosing energetic radiation" to probe the emission spectrum during the x-ray burn history of implosions at the NIF. One of the difficulties in inferring the hot spot temperature is the attenuation of the emission due to opacity from the shell and fuel. Therefore, a series of increasingly thick titanium filters were implemented to isolate the emission in specific energy regions that are sensitive to temperatures above 3 keV while not significantly influenced by the shell/fuel attenuation. Additionally, a relatively thin zinc filter was used to measure the contribution of colder emission sources. Since the signal levels of the emission through the thicker filters are relatively poor, a dual slit (aperture) was designed to increase the detected signal at the higher end of the spectrum. Herein, the design of the filters and slit is described, an overview of the solving technique is provided, and the initial electron temperature results are reported.

Analytic simulator and image generator of multiple-scattering Compton camera for prompt gamma ray imaging.

For prompt gamma ray imaging for biomedical applications and environmental radiation monitoring, we propose herein a multiple-scattering Compton camera (MSCC). MSCC consists of three or more semiconductor layers with good energy resolution, and has potential for simultaneous detection and differentiation of multiple radio-isotopes based on the measured energies, as well as three-dimensional (3D) imaging of the radio-isotope distribution. In this study, we developed an analytic simulator and a 3D image generator for a MSCC, including the physical models of the radiation source emission and detection processes that can be utilized for geometry and performance prediction prior to the construction of a real system. The analytic simulator for a MSCC records coincidence detections of successive interactions in multiple detector layers. In the successive interaction processes, the emission direction of the incident gamma ray, the scattering angle, and the changed traveling path after the Compton scattering interaction in each detector, were determined by a conical surface uniform random number generator (RNG), and by a Klein-Nishina RNG. The 3D image generator has two functions: the recovery of the initial source energy spectrum and the 3D spatial distribution of the source. We evaluated the analytic simulator and image generator with two different energetic point radiation sources (Cs-137 and Co-60) and with an MSCC comprising three detector layers. The recovered initial energies of the incident radiations were well differentiated from the generated MSCC events. Correspondingly, we could obtain a multi-tracer image that combined the two differentiated images. The developed analytic simulator in this study emulated the randomness of the detection process of a multiple-scattering Compton camera, including the inherent degradation factors of the detectors, such as the limited spatial and energy resolutions. The Doppler-broadening effect owing to the momentum distribution of electrons in Compton scattering was not considered in the detection process because most interested isotopes for biomedical and environmental applications have high energies that are less sensitive to Doppler broadening. The analytic simulator and image generator for MSCC can be utilized to determine the optimal geometrical parameters, such as the distances between detectors and detector size, thus affecting the imaging performance of the Compton camera prior to the development of a real system.

Energetic Radiation From Galactic Cosmic Ray Interactions With Saturn's Main Rings.

Saturn's main rings have an energetic particle and gamma ray photon radiation environment produced by ring interactions of galactic cosmic ray (GCR) protons and heavier ions penetrating the planetary dipolar magnetic field. Accurate models of this radiation environment are important for interpretation of Pioneer 11 and Cassini in situ measurements near the rings and for constraints on radiolytic contributions to neutral gas production and ice chemistry. A GEANT (GEometry ANd Tracking) based simulation is used to model flux spectra of protons, electrons, positrons, charged pions, neutrons, and gamma ray photons emitted from GCR interactions with H2O ice spheres approximating the ring material. Dependent on location in the A to D rings within the planetary magnetic field of Saturn, only GCR protons above respective energies of 20 to 72 GeV can reach the rings without being deflected away by the magnetic field. Calculated differential and integral fluxes from our simulations have good agreement with in situ Pioneer-11 measurements in selected energy channels. The charged particle and neutral radiation measurements are sensitive, respectively, to the sizes and areal mass densities of ring bodies. Computed gamma ray emission fluxes are 8% of our calculated limit for detection from the Earth by the Fermi Large Area Telescope. Addition of charged particle sensors and neutron-photon imaging spectrometers to a future Saturn Ring Observer mission would provide valuable information on the ring mass structure. The present paper provides a foundation for modeling of Pioneer 11 and Cassini radiation measurements across the main rings and future measurements of radiation from the rings.

VERITAS Observations of the BL Lac Object TXS 0506+056

Abstract On 2017 September 22, the IceCube Neutrino Observatory reported the detection of the high-energy neutrino event IC 170922A, of potential astrophysical origin. It was soon determined that the neutrino direction was consistent with the location of the gamma-ray blazar TXS 0506+056 (3FGL J0509.4+0541), which was in an elevated gamma-ray emission state as measured by the Fermi satellite. Very Energetic Radiation Imaging Telescope Array System (VERITAS) observations of the neutrino/blazar region started on 2017 September 23 in response to the neutrino alert and continued through 2018 February 6. While no significant very-high-energy (VHE; E > 100 GeV) emission was observed from the blazar by VERITAS in the two-week period immediately following the IceCube alert, TXS 0506+056 was detected by VERITAS with a significance of 5.8 standard deviations (σ) in the full 35 hr data set. The average photon flux of the source during this period was (8.9 ± 1.6) × 10−12 cm−2 s−1, or 1.6% of the Crab Nebula flux, above an energy threshold of 110 GeV, with a soft spectral index of 4.8 ± 1.3.

Abstract 4158: Differential intestinal tumorigenesis and DNA repair response in APCMin/+ mice after acute and fractionated proton radiation

Abstract Ionizing radiation (IR) exposure is a risk factor for colorectal cancer (CRC) development. With increasing interest in exploring outer space, astronauts on prolonged space missions such as a mission to Mars are expected to receive IR doses that could heighten the risk of CRC. It is estimated that about 90% of the IR in outer space is energetic protons, and the radiation dose during solar particle events (SPEs) could reach up to 2 Gy behind shielding. However, the risk of CRC after energetic proton radiation is not yet fully defined due to lack of human or animal model data. The purpose of the current study was to quantitatively and qualitatively compare and characterize differences in intestinal tumorigenesis between acute and fractionated proton irradiation in APCMin/+ mice, a well-established mouse model for human CRC. Mice were exposed to 1.88 Gy of proton radiation delivered in a single fraction or in 4 equal daily fractions (0.47 Gy x 4). Since proton dose to astronauts are variable based on space environment, in this initial study we chose a high single dose and a lower daily dose pattern to assess intestinal tumorigenesis. Intestinal tumor frequency and grade were noted, and tumor samples were collected from irradiated and control mice euthanized 100 to 110 days after radiation exposure. Molecular analysis was focused on DNA damage and repair, and cellular proliferative signaling pathways relevant to CRC using immunoblots, immunohistochemistry, and qPCR. Relative to control and fractionated-protons, there was significantly higher intestinal tumor frequency and grade after acute (single dose) proton irradiation. Decreased cellular differentiation and increased oxidative damage to DNA was observed after acute proton radiation. At the molecular level, our data showed increased DNA double strand breaks associated with decreased levels of DNA repair proteins, and upregulation of proliferative β-catenin and Akt signaling after acute proton exposure. Since increased DNA damage was not associated with concomitant increased apoptosis, our data suggest continued proliferation of cells bearing sub-lethal damage to promote tumorigenesis. In the fractionated proton group, tumor frequency and grade as well as molecular changes were comparable to sham-irradiated control group. When considered along with decreased tumor frequency and upregulation of DNA repair pathways after fractionation, our data are suggestive of marked differences in carcinogenic effects of acute vs. fractionated proton radiation. In summary, our data suggest that acute exposure to proton radiation is associated with higher risk of intestinal tumorigenesis in APCMin/+ mice with implications for gastrointestinal cancer risk in astronauts undertaking long duration space missions and in patients undergoing proton radiotherapy. Citation Format: Kamal Datta, Shubhankar Suman, Santosh Kumar, Albert J. Fornace. Differential intestinal tumorigenesis and DNA repair response in APCMin/+ mice after acute and fractionated proton radiation [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 4158.