Endotoxic Shock In Rats Research Articles

Protective effects of thromboxane synthetase inhibitors in rats in endotoxic shock.

HomeCirculation ResearchVol. 46, No. 6Protective effects of thromboxane synthetase inhibitors in rats in endotoxic shock. Free AccessAbstractPDF/EPUBAboutView PDFSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyRedditDiggEmail Jump toFree AccessAbstractPDF/EPUBProtective effects of thromboxane synthetase inhibitors in rats in endotoxic shock. W C Wise, J A Cook, P V Halushka and D R Knapp W C WiseW C Wise Search for more papers by this author , J A CookJ A Cook Search for more papers by this author , P V HalushkaP V Halushka Search for more papers by this author and D R KnappD R Knapp Search for more papers by this author Originally published1 Jun 1980https://doi.org/10.1161/01.RES.46.6.854Circulation Research. 1980;46:854–859 Previous Back to top Next FiguresReferencesRelatedDetails June 1, 1980Vol 46, Issue 6Article InformationMetrics Copyright © 1980 by American Heart Associationhttps://doi.org/10.1161/01.RES.46.6.854 Originally publishedJune 1, 1980 PDF download Advertisement

Influence of pharmaeologic agents on tissue metabolism in circulatory shock

Our research activities have been oriented to the effect of pharmacologic agents on tissue metabolism in the low flow state of circulatory shock. Specifically, we have been most interested in the effect of glucocorticoids on cellular metabolism because these agents exert a reproducible protective effect during septic and endotoxic shock in rats and monkeys. Further, we have studied the differences between untreated animals in shock and those treated with pharmacologic agents in an attempt to determine which cellular metabolic changes are critical to survival. This paper will present our studies as well as those of other laboratories, which have defined the effects on tissue metabolism of certain pharmacologic agents: those which stimulate cyclic adenosine monophosphate (AMP) (epinephrine, norepinephrine, glucagon, and prostaglandin) and those which do not (the glucocorticoids).