Endoscopic Sclerotherapy Of Esophageal Varices Research Articles

食道静脈りゅうに対する内視鏡的硬化療法に関する研究

昭和54年9月より昭和59年9月までに95例の食道静脈瘤に対し内視鏡的硬化療法を施行し有効な結果が得られた.特に直達手術後再発・遺残食道静脈瘤症例においては全例に食道静脈瘤の消失が認められた.高度肝機能障害,末期肝癌などの手術不能症例においては43例中,29例(67%)に食道静脈瘤の消失が認められた.また,内視鏡的硬化療法による食道静脈瘤の機序解明のため,剖検例(6例),雑種成犬,ウサギを用い,硬化剤注入後の組織の変化を経時的に観察した.その結果,硬化剤注入後より急性炎症が認められ,2週以降より組織内の線維化が増生され,その後,線維化による圧迫により静脈が閉塞され静脈瘤が消失すると考えられる.

Sclerotherapy of Esophageal Varices

Excerpt To the editor: The recently published recommendation on endoscopic sclerotherapy of esophageal varices (1) presents a complete and accurate picture of the current status of this important p...

Oesophageal stricture and dysphagia after endoscopic sclerotherapy for bleeding varices.

Oesophageal stricture and dysphagia after endoscopic sclerotherapy of oesophageal varices were assessed with regard to occurrence and severity and the relation to the treatment. We followed 34 patients for three to 47 months who had two to 25 treatments with submucosal, paravenous injections of polidocanol (3%). Twenty patients (59%) developed stricture or dysphagia; 14 both dysphagia and endoscopically verified stricture, two dysphagia without stricture, and four stricture without dysphagia. Both phenomena occurred intermittently and often independent of each other, but occupied median 38% of the observation time in these 20 patients. The patients developing strictures had received significantly more treatments and greater amount of sclerosant, and they had significantly more preceding mucosal necroses. The varices were eradicated to about the same degree and the incidence of recurrent haemorrhage was the same as in the patients who had not developed stricture.