The location of the skull base neoplasms are very deep, and the operation is unpredictable. The advent of skull base endoscopic technology has opened up a new surgical path for skull base neoplasms, but it also puts forward higher requirements for preoperative real-time images and detailed pathological anatomy. Obviously, traditional imaging techniques cannot keep up with it. 3D printing is a new stereoscopic rendering technology developed in recent years and applied to the medical field. It can seamlessly integrate, transform and reconstruct multi-modal imaging data such as CT/CT angiography/magnetic resonance imaging of patients into a three-dimensional model. The three-dimensional model is not only stereoscopic, intuitive, but also can display the complex anatomy of the skull base neoplasms and its surroundings point-to-point, and it can also be operated under the preoperative simulated endoscopic operation, so that the endoscopic surgery plan of the skull base neoplasms is more personalized and precise. It will undoubtedly further improve the total tumor resection rate and reduce the surgical side injury. This article reviews the application and progress of current 3D printing technologies in the field of endoscopic surgery of skull base neoplasms. Key words: Skull base neoplasms; Endoscopic surgery; 3D printing; Neurosurgery