Objective To investigate the effect of sterilization and supply center nursing quality control responsibility system on en -doscopic equipment supply quality.Methods From March 2011 to April 2012 , the implementation of 400 cases of equipment routine disin-fection mode were as the control group;from 2012 May to 2013 June, the nursing quality control responsibility system pattern in 400 cases were as the observation group , 120 doctors and nurses investigation were also investigated satisfaction .The quality of disinfection and doctors were compared.Results The infection rate in observation group equipment was 0.75%, which was lower than that of control group (3.00%) (P〈0.05);the washing, packaging, asepsis qualified rate of observation group were 99.00%, 100.00%, 100.00%, which were higher than those of control group ( P〈0.05 ) , the service attitude of clinical departments , sterile supply timely , effective communi-cation, sterile equipment quality satisfaction of observation group were 96.67%, 99.17%, 98.33%, 100.00%, which were higher than those of control group ( P〈0.05 ) .Conclusions The nursing quality control responsibility system could improve endoscopic equipment supply quality and clinical departments satisfaction. Key words: Disinfection supply center; Nursing quality control responsibility system; Endoscope; Supply quality; Hospital in-fection