Endocervical Gland Involvement Research Articles

The Effects of Endocervical Gland Involvement on the Cure Rates of Patients with Cervical Intraepithelial Neoplasia Undergoing Cryosurgery

The Effects of Endocervical Gland Involvement on the Cure Rates of Patients with Cervical Intraepithelial Neoplasia Undergoing Cryosurgery

The effect of endocervical gland involvement on the cure rates of patients with cervical intraepithelial neoplasia undergoing cryosurgery

Several authors have reported an increased failure rate using cryotherapy when the endocervical clefts or glands were involved in cervical intraepithelial neoplasia. Over a period of 5 years, November 1973 to November 1978, 248 patients with cervical intraepithelial neoplasia (CIN), satisfactory colposcopy, and colposcopically directed biopsy were treated with cryosurgery. Of the 248 patients, 160 patients had adequate follow-up. The failure rate was 16.3% ( 26 160 ). Sixty-three (39.4%) of the 160 patients had gland involvement. Of those patients with gland involvement, there was a failure rate of 27% (17 of 63 patients). The evidence suggests that the presence of gland involvement in patients with CIN adversely affects cure by cryosurgery. The degree of severity of CIN among patients who failed therapy was not a significant factor.

Arias-Stella Reaction of the Endocervix

The involvement of endocervical glands by the Arias-Stella reaction was investigated in 191 hysterectomy specimens obtained during pregnancy. The prevalence of the condition was 9% (17 of 191). The lesion was usually focal in nature and was more commonly present in the more proximal portions of the endocervical canal. The histologic appearance was markedly similar to the one in the endometrium. Nuclear enlargement and atypia, as well as a prominent hobnail pattern, were seen. Nuclear cytoplasmic inclusions and a glassy appearance of involved nuclei were occasionally observed.