Summary The objective of field studies conducted in 2009, 2010 and 2011 in the 6 locations was to evaluate the efficacy of mixture of pinoxaden with florasulam applied alone and with various herbicides (fluroxypyr, tribenuron methyl, dicamba with triasulfuron, 2,4‐dichlorophenoxy acetic acid (2,4‐D) with dicamba). Herbicides were applied in spring at the end of tillering of winter wheat. Experiments were arranged in a randomized block design. It was proved that the highest control of weed species like: Apera spica‐ venti, Galium aparine, Myosotis arvensis, Capsella bursa‐pastoris, Stellaria media, Papaver rhoes, Brassica napus and Matricaria inodora was provide by all tested tank‐mixture of herbicides (86 to 100%). Winter wheat plants were tolerant to pinoxaden with florasulam and their tank‐mixtures with fluroxypyr, tribenuron methyl, dicamba with triasulfuron, MCPA with dicamba. Herbicides used in studies resulted in higher winter wheat yields as compared with untreated plots. Implementation of these solutions to agricultural practice would allow more efficient weed control in winter wheat.