The design and construction of an inexpensive precision temperature control system used successfully for microculture applications is described. It is easily assembled from a homemade, precise, solid-state, proportional thermoregulator, resistive heating element, and insulated enclosure. The basic system easily adapts and can be customized for a variety of microculture applications with changes in enclosure dimensions or design. Control temperature accuracy, range and span can be varied by changing the components and design of the thermoregulator and enclosure. A series of such systems placed in a refrigerated or air-conditioned area accomodates multiple, parallel temperature treatments for experiments.