Encapsulation Material Research Articles

Enhanced strain transfer and optoelectronic performance in MoS2 devices via Formvar encapsulation

Abstract We systematically investigate the influence of polyvinyl formal (PVFM), commonly known as Formvar, in comparison to polycarbonate (PC) and polymethyl methacrylate (PMMA), as encapsulation materials on the strain performance of MoS2 monolayer and bilayer flakes on flexible polypropylene (PP) substrates. Notably, optical differential reflectance measurements reveal that PVFM and PMMA encapsulation significantly enhances the mechanical and thermal strain gauge factors by approximately 2-fold (up to ∼−50 meV/%) and 6-fold (up to ∼−1.5 meV/°C), respectively, while PC shows a slightly lower enhancement. Moreover, all three polymers increase the maximum achievable strain from approximately 1.4% to 2.3%. Furthermore, devices fabricated on PP substrates exhibit improved optoelectronic performance when encapsulated with PVFM, including increased and faster photocurrent response and extended device lifetime.

Preparation and evaluation of oral insulin nanocapsule delivery systems.

Insulin therapy is essential for regulating blood sugar levels. Conventional subcutaneous injection is prone to psychological stress, local tissue damage and severe blood glucose fluctuations, and thus the development of oral insulin technology has become an alternative therapy. However, oral insulin faces challenges such as difficult absorption, poor adhesion, low bioavailability, and short duration of action, due to the large molecular weight, low permeability, and easily degradable by enzymes and gastric acids. In this study, oral insulin nanocapsule delivery systems (Orl-Ins-NPs) were developed by using polylactic acid-co-glycolic acid (PLGA) as the encapsulation material for insulin loading. After preparation, optimization and characterization, the mean size of Orl-Ins-NPs was 140.08 nm, the encapsulation efficiency of the system was 54.3 %, and the loading capacity of insulin was 2.2 %. In addition, cationic modification with chitosan/ polyethyleneimine promoted adhesion and permeation of the intestinal mucus layer, and surface coating with pH-responsive methyl methacrylate trimethylamine ethyl chloride copolymer achieved 100 % gastric protection. The results of rat blood glucose test showed that, subcutaneous injection of the control group reduced blood glucose concentrations within 1 h and returned to initial levels within 4 h, while Orl-Ins-NPs slowly reduced blood glucose concentration to 51.3 % of the initial level and maintains stability within 10 h. Orl-Ins-NPs exhibited good physicochemical stabilities, sustained release property, improved in vitro acid resistance, as well as long-term in vivo hypoglycemic effect. This system demonstrates its potential clinical application in oral insulin and other protein drugs delivery.

Liquid-based encapsulation for implantable bioelectronics across broad pH environments

Wearable and implantable bioelectronics that can interface for extended periods with highly mobile organs and tissues across a broad pH range would be useful for various applications in basic biomedical research and clinical medicine. The encapsulation of these systems, however, presents a major challenge, as such devices require superior barrier performance against water and ion penetration in challenging pH environments while also maintaining flexibility and stretchability to match the physical properties of the surrounding tissue. Current encapsulation materials are often limited to near-neutral pH conditions, restricting their application range. In this work, we report a liquid-based encapsulation approach for bioelectronics under extreme pH environments. This approach achieves high optical transparency, stretchability, and mechanical durability. When applied to implantable wireless optoelectronic devices, our encapsulation method demonstrates outstanding water resistance in vitro, ranging from extremely acidic environments (pH = 1.5 and 4.5) to alkaline conditions (pH = 9). We also demonstrate the in vivo biocompatibility of our encapsulation approach and show that encapsulated wireless optoelectronics maintain robust operation throughout 3 months of implantation in freely moving mice. These results indicate that our encapsulation strategy has the potential to protect implantable bioelectronic devices in a wide range of research and clinical applications.

Tips and Tricks for a Good Encapsulation for Perovskite‐Based Solar Cells

ABSTRACTEncapsulation is a critical topic to ensure the successful implementation of perovskite photovoltaics. Recently, vacuum lamination has been shown as a promising approach that combines compatibility with current industrial processes in conventional photovoltaic (PV) manufacturing and suitability to achieve good results with perovskites. Here, we explore some of the attractive encapsulation materials in terms of their ability to prevent moisture ingress, withstand elevated temperatures, and have suitable mechanical properties to avoid thermomechanical issues. We utilized the previously suggested concept of the “perovskite test,” an optical test with simple sample fabrication, for evaluating encapsulation quality and validated the findings with the full solar cell stack. Unsurprisingly, encapsulants without an edge sealant showed insufficient protection from moisture. Ionomer in combination with butyl edge seal showed the best barrier properties; however, this stack led to rapid delamination of the cell layers in thermal cycling tests. Configuration with only edge sealant does not have such an issue in principle (no mechanical stress applied), but an absence of the polymer in the stack is unfavorable in terms of optical design and sometimes showed perovskite degradation that we assign to trapped moisture in the butyl itself. Polyolefin with butyl edge sealant is not free of degradation but showed the most promising compromise by passing the damp heat test and showing fewer issues in the thermal cycling experiments. In general, our material study and optimization presented in this manuscript show that a holistic approach is needed when choosing an optimal encapsulation scheme for perovskite devices.

Animal-free coacervates: The combination of fungal chitosan-gum Arabic for the encapsulation of lipophilic compounds.

In this study, fungal chitosan (FC) and gum Arabic (GA) were combined to develop non-animal complex coacervates for encapsulation. Optimal coacervate formation occurred at pH5 with a 1:4 (FC:GA) weight ratio. Innovative complementary approaches, including rheology coupled with phase-contrast microscopy, revealed that FC-GA coacervates could withstand high shear rates, reverting to their original structure afterward, making them suitable for industrial applications. FTIR, DSC, and TGA analyses confirmed the electrostatic interactions and thermal stability, making them suitable for high-temperature procedures like spray-drying or extrusion. Higher GA concentrations increased coacervate hydrophilicity, while low-dielectric-constant liquids reduced particle size and disrupted coacervates. This study also explored interactions with solvents used in cosmetics, finding that isohexadecane, ethylhexyl stearate, and ethanol improved wetting properties by reducing electrostatic interactions, while polar solvents such as water and glycerol hindered them due to stronger interactions. The coacervates effectively encapsulated α-tocopherol, achieving an 82.6% of encapsulation efficiency at a 1:1 (w/w) wall material-to-active ratio. These findings highlight the potential of FC-GA coacervates as stable, easy-to-prepare encapsulation materials for high-shear and high-temperature conditions, offering promising applications in the food, cosmetic, and pharmaceutical sectors.

Characterization of Self-Cured Silicone Oils for Encapsulation of Ultraviolet-C Light-Emitting Diodes.

The effectiveness of ultraviolet-C light-emitting diodes (UVC LEDs) is currently limited by the lack of suitable encapsulation materials, restricting their use in sterilization, communication, and in vivo cancer tumor inhibition. This study evaluates various silicone oils for UVC LED encapsulation. A material aging experiment was conducted on CF1040 (octamethylcyclotetrasiloxane), HF2020 (methyl hydro polysiloxanes), and MF2020-1000 (polydimethylsiloxane) under UVC radiation for 1000 h. The analysis assessed transmittance changes and chemical composition alterations throughout the aging process. Notably, HF2020 showed an increase in transmittance before 500 h, indicating a curing process attributed to the photolysis of Si-H, leading to the formation of Si-O-Si. Further testing on 265 nm UVC LEDs, both with and without HF2020 encapsulation, showed that the encapsulated LEDs exhibited a remarkable maximum increase of 27% in radiant power compared to their unencapsulated counterparts. Additionally, these encapsulated LEDs sustained higher radiant power levels during the first 200 h of operation. Notably, its potential application in photodynamic therapy is significant; by activating photosensitizers with higher UVC exposure, it facilitates the rapid production of reactive oxygen species, leading to effective cancer cell destruction within a short timeframe.

Investigating gum arabic and soy protein isolate as wall material for encapsulation of five strains of Lactobacillus.

Encapsulation technology is a suitable tool to protect probiotics in carrier food products and gastrointestinal tract. In the current investigation, the potential of gum arabic, soy protein isolate and their blend as wall material for the encapsulation of five Lactobacillus spp. viz. L. acidophilus, L. bulgaricus, L. casei, L. plantarum and L. rhamnosus by freeze drying was studied. The impact of various encapsulating materials on the encapsulation efficiency, water activity, particle size, thermal properties and morphology of encapsulates was investigated. The results revealed that microparticles have low water activity (0.25-0.37), high encapsulation efficiency (81.94 to 93.03%) and particle size ranged between 112.34 and 147.79μm. Scanning electron microscopy indicated a porous morphology and irregular shape of probiotic powder. The absorption bands in the FT-IR spectra between 2854 and 1088cm-1, 2927-109cm-1 and 2930-1071cm-1 confirm the successful encapsulation of probiotics. The encapsulated probiotics showed high lysozyme tolerance (76.00 to 92.16%) and high cell surface hydrophobicity (58 to 85%) as compared to free cells. This improves probiotic stability, survivability, and functional properties, making them ideal for developing functional food products. These encapsulated probiotics are well-suited to withstand gastrointestinal conditions and deliver health benefits to consumers.

Improved Operational Lifetime of MAPbI3 Solar Cells Encapsulated with Parylene‐N

Herein, unsubstituted poly‐para‐xylylene (parylene‐N) film as an encapsulation material for MAPbI3 perovskite solar cells (PSCs) is assessed. Unlike more commonly used parylene‐C, parylene‐N is cheaper and does not contain Cl which makes it a promising encapsulant for perovskite materials. Being deposited by room temperature chemical vapor deposition in a vacuum, 2 mm‐thick parylene film stabilizes MAPbI3‐based solar cells and inhibits the degradation even under stress test conditions (85 °C in the air). Moreover, the solar cells, encapsulated with the parylene‐N film and cover glass, show stable characteristics for over 3800 h in a dark ambient atmosphere, retaining 92% of their initial power conversion efficiency. Such results demonstrate the potential of unsubstituted parylene for PSC stabilization, paving the way for novel and highly stable PSCs.

On the longevity and inherent hermeticity of silicon-ICs: evaluation of bare-die and PDMS-coated ICs after accelerated aging and implantation studies

Silicon integrated circuits (ICs) are central to the next-generation miniature active neural implants, whether packaged in soft polymers for flexible bioelectronics or implanted as bare die for neural probes. These emerging applications bring the IC closer to the corrosive body environment, raising reliability concerns, particularly for chronic use. Here, we evaluate the inherent hermeticity of bare die ICs, and examine the potential of polydimethylsiloxane (PDMS), a moisture-permeable elastomer, as a standalone encapsulation material. For this aim, the electrical and material performance of ICs sourced from two foundries was evaluated through one-year accelerated in vitro and in vivo studies. ICs featured custom-designed test structures and were partially PDMS coated, creating two regions on each chip, uncoated “bare die” and “PDMS-coated”. During the accelerated in vitro study, ICs were electrically biased and periodically monitored. Results revealed stable electrical performance, indicating the unaffected operation of ICs even when directly exposed to physiological fluids. Despite this, material analysis revealed IC degradation in the bare regions. PDMS-coated regions, however, revealed limited degradation, making PDMS a suitable IC encapsulant for years-long implantation. Based on the new insights, guidelines are proposed that may enhance the longevity of implantable ICs, broadening their applications in the biomedical field.

Use of pennisetin-casein complex microparticles for Curcuma longa L. extract microencapsulation: Improvement of antioxidant and alpha-amylase inhibitory activities.

This study aimed to use a new protein complex of Pennisetin (Pen) a non gluten protein of pearl millet and casein (Cas), for curcumin (Cur) extract encapsulation using simple or complex coacervation. The potential improvement of Cur antioxidant activities and α-amylase inhibition after encapsulation was explored. Complex microparticles of Pen and Cas with various ratios exhibited average diameters ranging from 1.95±0.32 to 4.66±0.99μm, whereas the Cur loaded microparticles had average diameters ranging from 2.50±0.89 to 5.27±1.17μm. FTIR analysis of Cur loaded microparticles showed the presence of specific peaks at 3757, 1754, 1157 and 856cm-1 related to characteristic functional groups of Cur. This confirms the successful encapsulation of Cur. The major forces involved in microparticles formation were hydrophobic interaction and hydrogen bonding. The best encapsulation efficiency 68% and loading capacity 17% were obtained for the complex microparticles Pen:Cas (ratio 1:1.5). Encapsulating Cur within microparticles of Pen, Cas or their complexes significantly (p˂0.05) enhances their DPPH and ABTS.+ antioxidant activities and their pancreatic α-amylase inhibition percentage. These findings shed light on the potential use of Pen a non gluten protein, in its native form or complexed with Cas, as wall material for hydrophobic or hydrophilic bioactive compounds encapsulation.

Microencapsulation: An Innovative Technology in Modern Science

ABSTRACTMicroencapsulation is a methodology utilized across different areas to upgrade the viability, steadiness, and conveyance of bioactive compounds. Microencapsulation improves stability, controlled release, and sensory properties in pharmaceuticals, food products, agriculture, skincare products, and aquaculture by enclosing molecules within protective coatings. Spray drying, emulsification, and coacervation are techniques employed to tailor the release profiles and safeguard encapsulated compounds. The microencapsulation technique improves the shelf life and effectiveness of bioactive compounds, addressing challenges related to solubility, bioavailability, and targeted delivery. Despite its advantages, microencapsulation faces challenges concerning cost, scalability, and regulatory compliance. Ongoing research aims to enhance these techniques and materials, increasing cost‐effectiveness and facilitating applications in biotechnology, environmental science, and additional domains. This study explores the critical role of the microencapsulation approach in improving the stability and effectiveness of bioactive compounds across various applications, while also considering current challenges and future developments in improving the efficiency of encapsulation methods and materials.

Polyurethane-coated Double Perovskite (Cs4Mn1-xCdxBi2Cl12) Significantly Improves Stability and Flexible Anticounterfeiting

Impurity doping is widely recognized as an effective approach to enhancing the photophysical properties and expanding the application potential of halide perovskites. In this study, we employed a room-temperature co-precipitation method to synthesize luminescent powders of Cs3Bi2Cl9 perovskite doped with varying concentrations of Mn2+. As Mn2+ content increased, a phase transition from Cs3Bi2Cl9 to Cs4MnBi2Cl12 occurred, along with a continuous increase in luminescent intensity. Introducing Cd2+ ions mitigated the Mn2+-Mn2+ coupling effects, significantly enhancing luminescent intensity. Additionally, we investigated the structural and luminescent behavior of Cs4Mn1-xCdxBi2Cl12 in humid environments, revealing that water induces crystal dissociation and phase transitions, leading to fluorescence quenching. To address the common issue of limited stability in halide perovskites, we have innovatively chosen thermoplastic polyurethane (TPU) as the organic encapsulation material. This strategy effectively inhibits environmentally induced phase transitions, preserving the high brightness of Cs4Mn1-xCdxBi2Cl12 phosphors while significantly enhancing their thermal and water stability. Additionally, TPU imparts excellent flexibility and transparency to the phosphors, offering promising potential for applications in flexible anti-counterfeiting technologies.

The swelling mechanism of ethylene-vinyl acetate polymer in different solvents via molecular dynamics and experimental studies.

Ethylene-vinyl acetate (EVA) film is the predominant encapsulation material in crystalline silicon photovoltaic modules, the efficient and eco-friendly processing of which is essential for the recycling of the modules. Among the various existing techniques, the chemical approach uses solvents to induce swelling and dissolution on the EVA film to facilitate the separation of distinct layers. This method demonstrates the potential for achieving low-energy consumption and minimal-damage retrieval of the diverse materials within the components. Nonetheless, the mechanism underlying the swelling of the EVA polymer and the consequent delamination of various layers remains elusive, hindering the proper choice of solvents. In this study, the swelling behaviors of the EVA polymer in water, ethanol, and D-limonene solvents were analyzed via molecular dynamics (MD) simulations. The influence of intermolecular interactions on the swelling degree of the EVA polymers had been examined to determine the dominant factors leading to the discrepancies in the diffusion state of EVA in different solvents. The molecular electrostatic potential (MEP) maps were utilized to explain the differences in interactions from a molecular structure perspective. Furthermore, the results of MD simulations were experimentally verified by solvent-immersion experiments and testing methods. Based on the results, the swelling mechanism of the EVA polymer in the selected solvents was proposed and illustrated, providing theoretical support for chemically-driven photovoltaic module recycling processes.

A temperature compensation method for fiber Bragg gratings using negative thermal expansive β-eucryptite packaging

Abstract Fiber optic sensing measurements hold significant potential for various applications, but temperature compensation of fiber Bragg grating (FBG) remains a formidable challenge. This paper introduces the utilization of β-eucryptite as an encapsulation material for FBG, exploiting its negative thermal expansion property to achieve temperature compensation. A two-point adhesive sealing technique was employed to affix FBG to the β-eucryptite substrate. While bare FBG and sensors encapsulated in 7075 aluminum alloy served as comparison. Experimental outcomes reveal that the FBG encapsulated in β-eucryptite exhibits temperature sensitivities of 1.67 pm °C−1 within the temperature ranges of −30 °C to 150 °C. In contrast, bare FBG and sensor encapsulated with 7075 aluminum alloy display temperature sensitivities of 10.46 pm °C−1 and 37.31 pm °C−1, respectively. The use of β-eucryptite for sensor encapsulation effectively reduces the temperature sensitivity of FBG. This temperature compensation method is straightforward yet promising and has great potential in aerospace and precision instrument measurement.

Sustainable Solar Module Through the Substitution of Materials by Renewable Encapsulation, Recycled Backsheet, and Lead‐Free Interconnection

ABSTRACTSustainability and resource‐efficiency are the major topics for the 21st century. Most of the PV modules are manufactured of glass, polymers, metals, and silicon‐based solar cells. All these materials have the potential to be substituted by sustainable products. The substitution of materials for PV modules is challenging because of issues in significant unknown risks for short‐ and long‐term reliability of the PV module. Investigations for material and process routes of a 100% renewable solar module are necessary. This study investigates the suitability and reliability of different materials. For example, the reliability of an electrically conductive adhesive (ECA) to a leaded‐solder reference is under investigation as well as various polymers (recycled, bio‐based, or biodegradable). In the first step, the interconnections are tested with a standard module encapsulation bill of materials (known good reference). In the second step, the module encapsulation and backsheet materials are substituted by their sustainable counterparts. The goal is to identify the most promising material combinations for further integration of lead‐free interconnected solar cells. Reliability is assessed using accelerated ageing tests in accordance with IEC 61215/IEC 61730 with standard test duration and extended test duration for each material and interconnection batches. The condition of the samples is assessed by regular visual inspection, power measurements, and electroluminescence images. The study aims to demonstrate and assess the suitability and reliability of the selected material combinations to enable the steps toward a renewable material solar module.

Cellulose-based encapsulation for all-printed flexible thermoelectric touch detectors

Printed and flexible electronics have gained considerable scientific attention in recent years, driving the demand for low-energy production techniques, eco-friendly materials and flexible substrates. However, effective encapsulation is essential to protect these devices in harsh environmental conditions. Thus, sustainable encapsulant materials are critical for advancing flexible electronics. In this work, we studied three encapsulant materials—commercial plastic, polyvinyl alcohol and ethyl cellulose—applied to thermoelectric touch sensors printed on paper and fabric substrates. Ethyl cellulose demonstrated promising properties in terms of flexibility, water resistance and transparency, along with a low carbon footprint. Encapsulated substrates with ethyl cellulose exhibited high contact angles (121° on fabric and 116° on paper), indicating robust water repellency. Thermal stability tests showed minimal mass loss (10%) at 315 °C, confirming its temperature resilience. Furthermore, sensors encapsulated with ethyl cellulose retained their electric performance after water submersion for 1 min and withstood 100 bending cycles, maintaining response times below 1 s and signal output around 100 µV. These findings highlight ethyl cellulose as a viable green encapsulant material compatible with large-scale sustainable electronics manufacturing.

Preparation, Characterization and Application of Sustainable Composite Phase Change Material: A Mineral Material Science Comprehensive Experiment

Phase change materials (PCMs) play a significant role in achieving sustainable objectives for green buildings. Organic solid–liquid PCMs have excellent heat energy storage density and suitable working temperatures, making them a focal point of research attention. However, these materials face challenges such as potential leakage, low thermal conductivity, and limited fire resistance, which hinder their direct application in the construction industry. Therefore, mineral-based PCMs are highly regarded due to their safety features, environmental friendliness, non-toxicity, and cost-effectiveness within sustainable building development. In this work, a multistage porous kaolinite-based geopolymer encapsulation material using primary raw materials like kaolinite mineral, sodium silicate surfactants, and hydrogen peroxide was successfully synthesized. The PEG is used as the organic solid–liquid PCM while natural graphite mineral serves as a heat transfer enhancement agent to fabricate a novel and sustainable mineral-based composite PCM, which could be applied at the environment temperature from 35–60 °C approximately. Furthermore, a study on material properties was conducted to investigate influencing factors. Comprehensive experimental reform on mineral-based PCMs will offer proficiency in experimental operations and foster the talents’ capacity for comprehensive design, which holds immense significance for understanding and designing mineral materials. This work holds great significance for the sustainable development for education and green buildings.

Review: Biomacromolecules‐based encapsulation technologies for the protection of oxygen‐sensitive next‐generation probiotics

AbstractIn the recent years, various strains of the gut microbiota have been discovered to possess significant therapeutic potential, they are defined as next‐generation probiotics (NGPs). Akkermansia, Faecalibacterium, Bacteriodes, Eubacterium, and Bifidobacteria are among the typical NGP strains which exhibit several interesting bioactivities as live biotherapeutics. However, some strains of NGP are extremely sensitive to oxygen, such as Faecalibacterium prausnitzii. This hinders their cultivation and large‐scale production. Therefore, it is essential to develop a strategy to protect them during production, storage, and colonic administration. This review, highlights key NGP strains developed in recent years, alongside the encapsulation strategies used to protect them. The primary criterion for selecting encapsulating techniques is their feasibility to be performed under strictly anaerobic conditions. Various processes have been selected according to the physical forms of the products, including liquid, gel, and solid forms, as well as the final shaping of the product. The critical factors for selecting encapsulation materials include biocompatibility, safety, effective oxygen barrier properties, and an optimal release profile in the gastrointestinal tract. This review discusses protection strategies aimed at improving the survival and thereby effectiveness of NGPs.

Transition Boundary from Laminar to Turbulent Flow of Microencapsulated Phase Change Material Slurry-Experimental Results.

An ice slurry or an emulsion of a phase change material (PCM) is a multiphase working fluid from the so-called Latent Functional Thermal Fluid (LFTF) group. LFTF is a fluid that uses, in addition to specific heat, the specific enthalpy of the phase change of its components to transfer heat. Another fluid type has joined the LFTF group: a slurry of encapsulated phase change material (PCM). Technological progress has made it possible for the phase change material to be enclosed in a capsule of the size of the order of micrometers (microencapsulated PCM-mPCM) or nanometers (nanoencapsulated PCM-nPCM). This paper describes a method for determining the Reynolds number (Re) at which the nature of the flow of the mPCM slurry inside a straight pipe changes. In addition, the study results of the effect of the concentration of mPCM in the slurry and the state of the PCM inside the microcapsule on the value of the critical Reynolds number (Recr) are presented. The aqueous slurry of mPCM with a concentration from 4.30% to 17.20% wt. flowed through a channel with an internal diameter of d = 4 mm with a flow rate of up to 110 kg/h (Re = 11,250). The main peak melting temperature of the microencapsulated paraffin wax used in the experiments was around 24 °C. The slurry temperature during the tests was maintained at a constant level. It was 7 °C, 24 °C and 44 °C (the PCM in the microcapsule was, respectively, a solid, underwent a phase change and was a liquid). The experimental studies clearly show that the concentration of microcapsules in the slurry and the state of the PCM in the microcapsule affect the critical Reynolds number. The higher the concentration of microcapsules in the slurry, the more difficult it was to maintain laminar fluid flow inside the channel. Furthermore, the laminar flow of the slurry terminated at a lower critical Reynolds number when the PCM in the microcapsule was solid. Caution is advised when choosing the relationship to calculate the flow resistance or heat transfer coefficients, because assuming that the flow motion changes at Re = 2300, as in the case of pure liquids, may be an incorrect assumption.

OPTIMIZATION OF CURCUMIN ENCAPSULATION FORMULA WITH CHITOSAN AND ALGINATE USING SIMPLEX LATTICE DESIGN AND ITS EFFECT ON ANTIOXIDANT ACTIVITY

Curcumin is known to enhance the performance of antioxidant serums, such as superoxide dismutase (SOD). However, curcumin is prone to degradation when exposed to sunlight, necessitating the use of encapsulation technology to protect it from chemical degradation and improve its dispersibility. Biopolymers like chitosan and alginate are commonly used as encapsulation materials. This study aimed to determine the ideal concentrations of chitosan and alginate for curcumin encapsulation and evaluate its antioxidant activity. The optimal formulation was identified using Design Expert software version 13 with a Simplex Lattice Design. Encapsulation was carried out through the ionic gelation method, and the curcumin encapsulates were evaluated for encapsulation efficiency, particle size, zeta potential, and antioxidant activity. The optimal formulation was found to be 1.35% chitosan and 2.145% alginate, achieving an encapsulation efficiency of 71.85%, a particle size of 551.1 nm, a zeta potential of -46 mV, and strong antioxidant activity with an IC50 value of 36.32 ppm. In conclusion, the Simplex Lattice Design method successfully optimized the formulation. Chitosan increased particle size, while alginate enhanced encapsulation efficiency. The antioxidant activity was minimally affected by encapsulation, as most curcumin was retained in the droplets. The zeta potential value confirmed the stability of the encapsulate.