Abstract Continuous changes in the global climate have exacerbated the uneven spatial distribution of water resources. The quantitative response relationships between precipitation and its influencing factors are an important research topic. In this study, the responses of precipitation to its influencing factors were quantified by analysing the large-spatial-scale data such as the monthly precipitation data of 619 meteorological stations in China from 1951 to 2018, the CMIP6 data, and the AMO through empirical orthogonal function decomposition, partial redundancy analysis, and ensemble empirical mode decomposition. As shown by the results, the overall response relationships between precipitation in China and the AMO and MEI were relatively strong, and the PDO and AGG affected precipitation in western China. The precipitation in the area north of 25 °N had strong response relationships with the SR and AO. AP affected the precipitation in Northeast China, while WS affected the precipitation in North China and western China. RH affected the precipitation in the regions south of 25 °N. The response relationship between precipitation and CO2 was weakest. The total contribution rate of the influencing factors to the annual precipitation was higher in the west and lower in the east. In the regions west of 100 °E, the total contribution rate of the influencing factors to annual precipitation increased from south to north. In the regions east of 100 °E, the total contribution rate of the influencing factors to the annual precipitation decreased from north and south to the central area, AO and AP contributed little to the annual precipitation across China.