In contrast to prior reviews, this study provides a review of research contexts, research designs, and theories used in restaurants’ business performance research. It also identifies measures and antecedents of restaurants’ business performance. Additionally, this systematic review highlights gaps for future research on restaurants’ business performance. A total of 148 articles were obtained from the Web of Science (WoS) database (1997 till February 2021) and then 33 articles were identified as eligible for the final analysis. Based on reviewing findings, this article proposes some intriguing research questions and contributes actionable results for practice. This research ends with a framework that draws the findings concurrently to apprise future theoretical and empirical advances in the area.