Health is an integral feature of immigration, providing not only insight into population health but also a critical lens into immigrant integration and the power structure in receiving countries. The goal of this article is to chart the trajectory of scholarship on immigrants’ health, focusing on the formative shift away from dominant individualistic perspectives focused on cultural and behavioral explanations toward a profoundly structural understanding of immigrants’ health. Focusing primarily on the US context, we synthesize theoretical and empirical advances in structural perspectives of immigrants’ health. We anchor these advances in the concept of exclusion, detailing how it undergirds structuralist perspectives of immigrants’ health. We review common ways in which exclusion has been measured in the empirical literature on immigrants’ health and highlight recent evidence linking exposure to exclusion to immigrants’ health outcomes across the life course. We conclude by discussing key directions and challenges for future research.