Emotional Well-being Subscale Research Articles

Effectiveness of Physical Activity Counseling in University Students Educated by Distance Learning During COVID-19 Pandemic: A Randomized-Controlled Trial.

Purpose: Students educated by distance learning experienced more physical inactivity and poorer quality of life (QOL) due to COVID-19 pandemic. Current study aimed to reveal the impacts of 4-week physical activity counseling (PAC) on step counts, physical activity (PA), anxiety, depression, and QOL in university students. Methods: Students (19.97±1.14 years) were randomly grouped as PAC (n=15, progressive increases in step counts) or control (n=16, maintaining routine activities). Step count, PA, anxiety, depression, and QOL were evaluated remotely. The students were followed up between December 2020 and March 2021. Results: Out of all students (4147.32±2916.54 steps/day), 29% were inactive; 67.7% had anxiety; 61.3% were depressed before PAC. After PAC, step count (mean difference (MD): 3999.69 steps/day, Cohen’s d=1.8), total walking (MD: 734.15 MET-min/week, Cohen’s d=0.4) and total PA (MD: 924.22 MET-min/week, Cohen’s d=0.4) scores, and role limitations due to emotional problems, vitality, and emotional well-being subscales scores of QOL significantly increased in PAC group compared with controls; anxiety scores decreased vice versa (p<0.05). Changes in depression, total vigorous and moderate PA scores, and other QOL subscales scores were similar between groups (p>0.05). Conclusion: While PAC, a feasible, effective, and safe method during COVID-19 pandemic, improved anxiety, step count, PA level and QOL in students, PAC did not affect depression and some domains of QOL. Therefore, PAC should be offered to students and explored in other segments of society to prevent long-term effects of COVID-19.

Effects of CIK Cell Therapy Combined with Camrelizumab on the Quality of Life in Patients with Nasopharyngeal Carcinoma and Analysis of Prognostic Factors.

Objective To investigate the effects of CIK (cytokine-induced killer) cell therapy combined with camrelizumab on the quality of life in patients with nasopharyngeal carcinoma and prognostic factors. Methods In this retrospective study, the materials of 80 patients with nasopharyngeal carcinoma treated in our hospital (February 2017–February 2019) were retrospectively analyzed, and they were equalized into experimental group (n = 40) and control group (n = 40) according to the order of admission. Both groups received 200 mg of camrelizumab on day 1 combined with 10 mg of anrotinib from day 2 to day 4. The patients received the above program every 3 weeks and 4 treatment cycles. The experimental group also received CIK cell therapy simultaneously. The patients' quality of life, immune indexes, local control, metastasis, and survival rate were compared between the two groups, and the prognostic factors were analyzed by logistic analysis. Results Compared with the control group, the experimental group achieved much higher scores of physical well-being (18.38 ± 2.31), social/family well-being (16.40 ± 2.24), emotional well-being (15.35 ± 2.30), functional well-being (17.30 ± 2.20), and head and neck cancer subscale (15.40 ± 2.01, P < 0.001) and eminently better immune indexes (P < 0.001) after treatment. During the 24-month follow-up, there were 2 recurrent cases (5.0%) and 2 cases (5.0%) with distant metastasis among the 40 patients in the experimental group; there were 8 recurrent cases (20.0%) and 7 cases (17.5%) with distant metastasis among the 40 patients in the control group. In the experimental group, the median survival period was 18 months and the 2-year survival rate was 97.5% (39/40). In the control group, the median survival period was 14 months and the 2-year survival rate was 85.0% (34/40). Among the 80 patients, 7 cases (8.75%) died and 73 cases (91.25%) survived. After conducting the single-factor analysis, remarkable differences in the cases of IV stage, quality of life after treatment, and immune indexes after treatment between the survival group and the death group were observed (P < 0.05). According to the multiple-factor analysis, the clinical stage and immune indexes were identified as the prognostic factors. Conclusion CIK cell therapy combined with camrelizumab can enhance the life quality and immune function of the patients with nasopharyngeal carcinoma, thus improving their prognoses.

Quality of Life of Chronic Hepatitis B Patients Consuming Nucleoside Analog: A Case-Control Clinical Study in Indonesia

Introduction: Chronic hepatitis B raises serious concern due to its high morbidity, such as cirrhosis and hepatocellular carcinoma, and mortality from 267 per 100,000 person-years. Up to now, medical therapy that successfully eradicates the hepatitis B virus is not available. Therapy is given in the long term for suppressing viral replication and disease progression. Nucleoside analog (NA) is a medication that is consumed orally once a day for years. Previous studies showed that patients who were treated with NA had a different quality of life (QoL) compared to naïve patients. This research aimed to analyze the QoL of chronic hepatitis B patients who consumed NA by comparing it with naïve patients at Dr. Soetomo General Academic Hospital Surabaya. Methods: Subjects were recruited consecutively from chronic hepatitis B patients at Dr. Soetomo General Academic Hospital Surabaya during 9 February – 31 May 2021. Data about sociodemographic characteristics, hepatitis B therapy history, and QoL were gained by using the SF-36 questionnaire and medical records. Subjects were divided into NA and naïve groups which responses underwent an analytical comparison. Results: NA group had significantly higher QoL in a physical component score (PCS) and mental component score (MCS), with physical functioning (PF), role limitations due to physical health (RP), role limitations due to emotional problems (RM), energy/fatigue (VT), emotional well-being (MH), social functioning (SF), and general health perception (GH) subscales having p&lt;0.05Conclusion: The QoL of patients who were treated with NA was significantly higher than that of naïve patients in terms of physical and mental components.

Quality of Life in Children and Adolescents with Gastroesophageal Reflux Disease

Objective: Children with gastroesophageal reflux disease (GERD) have significant co-morbidity. This study aimed to evaluate the health-related quality of life (HRQoL) in these children and adolescents by self and parent questionnaires. In addition, we also investigated the impact of gastroesophageal reflux symptoms on HRQoL. Material and Methods: The study included 93 patients with GERD and 59 age and sex-matched healthy controls. We asked the children and their parents to complete the validated Turkish version of KINDer Lebensqualitätsfragebogen-Children Quality of Life Questionnaire (self-report and parent report, respectively) for assessing HRQoL. The patients have additionally completed a gastroesophageal reflux symptom questionnaire. Results: The patients and their parents scored significantly lower on the general health perception (p=0.004) than the healthy controls. Especially physical well-being and emotional well-being subscales were negatively affected (p=0.000, and p=0.002, respectively). The most common symptoms in the patients were epigastric pain (70.9%), abdominal distention (64.5%), halitosis (58%), and regurgitation (50.6%). Epigastric pain significantly negatively affected the total HRQoL score in the patients (p= 0.003). The patients with GERD scored significantly higher than their parents in physical well-being (p=0.000) and family (p=0.000) subscale scores. The patients with GERD evaluated their quality of life more negatively in self-esteem (p=0.000) and school domains (p=0.001) than did their parents. Conclusion: GERD has a significant negative impact on HRQoL in children. The most affected domains are physical well-being and emotional well-being. Epigastric pain is associated with worse HRQoL scores.

Symptom experience and care needs of Turkish palliative care patients.

Nurses need to focus on supporting patients' quality of life, supporting their families, reducing the morbidity rate, providing psychosocial support services to improve symptom management and delivering high-quality care. This study aimed to determine the symptom experience and care needs of Turkish patients who received inpatient treatment in palliative care units. This descriptive research was conducted between May 2019 and May 2020. The study sample was composed of 200 palliative care patients selected using a convenience-purposive sampling method. The personal and disease-related characteristics were collected using the Patient Information Survey and the Functional Assessment of Chronic Illness Therapy-Palliative Care scale. The mean age of the sample was 75±15 years, and 56.5% were women. The patients' overall quality of life scores were below average (mean 84.05±19.44). The functional wellbeing and other concerns subscales of the scale were affected the most adversely. The Physical Wellbeing subscale was affected minimally, while the Emotional Wellbeing and Social Wellbeing subscales were affected moderately. Conclusion: The palliative care patients mostly needed support for the prevention and management of infections, management of respiratory distress and swallowing problems, dealing with confusion and improving compliance with treatment. The low quality of life scores emphasise the importance of urgent interventions for improving the functional wellbeing and symptom management in these patients.

Real-world health-related quality of life and caregiver need in patients with metastatic hormone-sensitive and metastatic castration-resistant prostate cancer.

54 Background: Prostate cancer (PC) is one of the most common cancers in men. When making treatment decisions, patient health-related quality of life (HRQoL) and caregiver need are important considerations, and as such it is imperative to understand the impact that PC has on HRQoL. We aimed to assess the impact of metastatic hormone-sensitive PC (mHSPC) and castration-resistant PC (mCRPC) on HRQoL and associated caregiver need. Methods: Real-world data were drawn from the PC Disease Specific Programme, a point-in-time survey conducted in the United States of America and Europe (France, Germany, Italy, Spain and the United Kingdom) between Jan-Aug 2020. Physicians completed patient record forms for their next 8 consecutively consulting adult metastatic PC patients (4 mHSPC/4 mCRPC). Eligible patients were invited to complete a voluntary patient self-reported form on caregiver need and HRQoL including EuroQol 5-dimension 5-level (EQ-5D-5L), EuroQol Visual Analogue Scale (EQ-VAS), Functional Assessment of Cancer Therapy – General/Prostate (FACT-G/P) and Brief Pain Inventory (BPI) questionnaires. Higher scores indicate better HRQoL and more pain. Data were analysed descriptively. Results: 376 mHSPC and 331 mCRPC patients completed patient self-reported forms. Demographics and clinical characteristics for mHSPC/mCRPC patients were: mean age 71.1/71.5 years, 77%/69% of patients had an ECOG performance status of 0-1, 82%/83% of patients were retired and 42%/44% of patients had a caregiver. At data collection, mean HRQoL scores for mHSPC/mCRPC patients were: 66.4/63.4 (EQ-VAS), 0.76/0.72 (EQ-5D-5L), 66.2/62.9 (FACT-G) and 94.6/90.2 (FACT-P). Patients with mHSPC had FACT-P social, emotional, functional and physical well-being subscale scores of 18.2, 14.7, 13.6 and 19.7, respectively. These scores were 17.7, 14.0, 12.7 and 18.5 in mCRPC patients, respectively. Mean “worst pain” scores were mild (3.6/3.9 on BPI for mHSPC/mCRPC patients). In terms of both non-professional and professional caregivers, mHSPC/mCRPC patients reported a mean of 31.6/28.9 care hours/week. Most caregivers were partners/spouses (in 89% of mHSPC and 82% of mCRPC patients) providing a mean of 29.0 and 27.7 care hours/week, respectively. Conclusions: We showed that HRQoL and well-being are impacted in both mHSPC and mCRPC patients, and that there is a considerable time burden on caregivers. Patients with mCRPC reported the lowest HRQoL scores and highest pain scores, suggesting that patients who are sicker may have greater disease burden. Our findings suggest an unmet need for HRQoL in patients with mHSPC and mCRPC, and also a need for greater caregiver support in these patients.

Therapeutic Efficacy of Traditional Chinese Medicine Syndrome-Based Formulae to Neuropathic Pain Caused by Chemotherapy.

Objective:Chemotherapy-induced neuropathic pain (CINP) is a troublesome complication of anti-cancer treatment. The aim of this retrospective study was to investigate the effectiveness of classic Chinese herbal formulae (CHF) Huang Qi Gui Zhi Wu Wu Tang (HQGZWWT) and Dang Gui Si Ni Tang (DGSNT) in the treatment of CINP.Materials and Methods:Douleur Neuropathique 4 (DN4) and Functional Assessment of Cancer Therapy-General (FACT-G) questionnaires were rated at baseline and after 3-monthly CHF treatment.Results:By searching through our medical records of all the CIPN patients from 2018 to 2019, we identified and enrolled 37 patients with Deficiency-Cold syndrome in the study, for whom the treatment of neuropathic pain by regular pharmacotherapies had failed or intolerable. At the third month evaluation with the DN4 questionnaire, 13 patients had symptomatic remission, 15 patients remained stable, and 9 patients had no response to CHF. The 3-month mean DN4 score was significantly higher than that at the baseline (P < .001). After CHF treatment, significant differences in quality of life were noted in the physical, social, emotional, and functional well-being subscales, and in the total score, of the FACT-G (P < .001). No adverse events or instances of disease progression were observed.Conclusions:The results of our small study are the first in the literature to show the clinical effectiveness of CHF for CINP. Combination of HQGZWWT and DGSNT is well tolerated and may offer the possibility to ameliorate CINP more than conventional care can. It merits further investigation.

Longitudinal Assessment of Prognostic Understanding in Patients with Advanced Lung Cancer and Its Association with Their Psychological Distress.

Accurate prognostic understanding in patients with advanced cancer is essential for shared decision making; however, patients may experience psychological burden through knowing the incurable nature of advanced cancer. It has been unclear how their prognostic understanding fluctuates and whether accurate prognostic understanding is associated with psychological distress from the time of diagnosis over time. We longitudinally investigated prognostic understanding in 225 patients with newly diagnosed advanced lung cancer at 16 hospitals in Japan until 24 months after diagnosis. We examined associated factors with being consistently accurate in prognostic understanding, especially focusing on its association with psychological well-being. The proportion of patients with an inaccurate prognostic understanding remained approximately 20% over time with the presence of patients with inconsistent understanding. Patients with consistently accurate prognostic understanding showed a significantly lower Emotional Well-Being subscale score at both 3 and 6 months after diagnosis (p=.010 and p=.014, respectively). In multivariate analyses, being consistently accurate in prognostic understanding was significantly associated with female gender and higher lung cancer-specific symptom burden at 3 months (p=.008 and p=.005, respectively) and lower emotional well-being at 6 months (p=.006). Although substantial proportions of patients with advanced lung cancer had inaccurate prognostic understanding from the time of diagnosis over time, patients with consistently accurate prognostic understanding experienced greater psychological burden. Our findings highlight the importance of continuous psychological care and support for patients who understand their severe prognosis accurately. This study demonstrated that approximately 20% of patients with advanced lung cancer had an inaccurate understanding about their prognosis, not only at the time of diagnosis but also at the later time points. Being consistently accurate in prognostic understanding was significantly associated with elevated levels of psychological distress. Although accurate prognostic understanding is essential for decision making for treatment and advance care planning, health care providers should be aware of psychological burdens in patients that accept their severe prognosis accurately. Appropriate care and support for such patients are warranted from diagnosis over time.

Process-oriented and personalized psychotherapeutic care for epilepsy: Interim results of a feasibility study

BackgroundThere is great scientific and clinical interest in the effective integration of psychological treatments into comprehensive epilepsy care to optimize treatment outcomes and psychosocial functioning in people with epilepsy. Stepped care is a promising approach to accommodate personalized psychotherapeutic care in academic and regular outpatient settings. It aims at providing patients with the most adequate treatment duration, number of sessions, and treatment method while systematically monitoring their treatment processes. MethodsThis is an uncontrolled feasibility study of process-oriented and personalized psychotherapeutic care for epilepsy in a naturalistic setting. The objective of this study was to evaluate individual changes of health-related quality of life (QOLIE-31) and psychiatric comorbidity (BDI-II, BSI) in participants by applying the concept of the reliable change index (RCI) to outcomes that were obtained at baseline and six months after the beginning of the intervention. Additionally, we assessed the relationship between outcome scores, the number of attended sessions, and history of childhood trauma by linear regression models. ResultsTwenty patients [15 women/5 men, median age 48 years (range: 23–73 years)] were recruited. The median number of scheduled sessions was 11 (range: 6–22); there were no drop-outs. After psychotherapy quality of life (QOLIE-31), global distress (BSI) and depression (BDI-II) scores improved significantly (p-values: QOLIE-31: 0.03; BSI: 0.01; BDI-II: 0.01). The largest improvements were achieved for the emotional well-being subscale of the QOLIE-31 (47%, p-value: 0.02), the global severity index of the BSI (83%), and depression severity (BDI-II) (60%). Linear regression models did not reveal any significant association between interim changes, number of attended treatment sessions, and history of childhood trauma. ConclusionThe results suggest that process-oriented and personalized psychotherapeutic has low attrition and results in improved quality of life and reduced psychiatric symptoms in people with epilepsy. Our findings indicate that responsiveness to psychotherapy is not dependent on the number of attended treatment sessions. Participants with childhood trauma did not need more treatment sessions to achieve an improvement. More research is needed to understand and address mechanisms and precursors of responsiveness to psychotherapy.

Positive and negative aspects of mental health after unspecified living kidney donation: A cohort study.

ObjectivesUnspecified donors give a kidney to a stranger with end‐stage kidney failure. There has been little research on the long‐term impact of unspecified donation on mental health outcomes. The aim of this study was to assess the positive and negative aspects of mental health among unspecified donors.DesignWe invited all unspecified donors who donated a kidney between 2000 and 2016 at our centre to participate in an interview and to complete validated questionnaires.MethodsWe measured positive mental health using the Dutch Mental Health Continuum‐Short Form (MHC‐SF), psychological complaints using the Symptoms Checklist‐90 (SCL‐90) and psychiatric diagnoses using the Mini‐International Neuropsychiatric Interview (M.I.N.I.) Screen for all donors and the M.I.N.I. Plus on indication.ResultsOf the 134 eligible donors, 114 participated (54% female; median age 66 years), a median of 6 years post‐donation. Scores on emotional and social well‐being subscales of the MHC‐SF were significantly higher than in the general population. Psychological symptoms were comparable to the general population. Thirty‐two per cent of donors had a current or lifetime psychiatric diagnosis. Psychological symptoms did not significantly change between the pre‐donation screening and the post‐donation study.ConclusionsWe concluded that, with the appropriate screening, unspecified donation is a safe procedure from a psychological perspective.

Kanser Tedavisinin İşlevsel Değerlendirmesi Ölçeği FACT-G Türkçe Versiyonunun Geçerlik ve Güvenilirliği

Objective: Many of the cancer-specific quality of life (QOL) questionnaires improved over the last 20 years, can be contemplated as reference measures. The Functional Assessment of Chronic Illness Therapy (FACIT) system is an based and generic health-related quality of life measures. The aim of this study was conducted to test the reliability and construct validity of the Functional Assessment of Cancer Therapy General (FACT-G) for Turkish cancer patients. Material and Methods: This research is a methodological study. The data were obtained by using the sociodemographic and the FACT-G questionnaire. The sample comprised 148 cancer pa¬tients. Data were analysed by using the SPSS package program, descriptive statistics and to assess the reliability of the scales, cronbach alpha coefficient, item total score analysis, and, item total correlation coefficient (Pearson's correlation). For the construct validity of the instrument; exploratory factor analysis and confirmatory factor analysis were used. Results: The mean total score of FACT-G was 60.71±14.42, and for the physical, social/ family, emotional and functional well-being subscales 15.83±5.48, 13.91±4.90, 13.45±5.03 and 17.51± 5.04, respectively. The alpha coefficient was 0.88 for the global scale of the FACT-G questionnaire and ranged from 0.70 to 0.79 across subscales. A statistically significant positive correlation was found between FACT-G and test-retest scores of the four sub-dimensions (p=0.001). Conclusion: In this study, as a result of evaluating the psychometric properties of the FACT-G scale, the scale is a valid and reliable tool for use in Turkish patients with cancer.

Health-related quality-of-life (HRQoL) analysis from a randomized phase II trial of androgen signaling inhibitors with or without androgen deprivation therapy (ADT) for castration-sensitive prostate cancer: LACOG 0415.

64 Background: LACOG0415 is a 3-arm randomized trial evaluating ADT with abiraterone acetate plus prednisone (ADT+AAP), apalutamide alone (APA) or apalutamide with AAP (APA+AAP) for patients with locally-advanced, high-risk biochemical recurrence or metastatic castration-sensitive prostate cancer (ASCO 2020). In this trial, ADT+AAP and APA+AAP achieved the primary endpoint of percentage of patients with PSA ≤ 0.2 ng/mL at week 25. Apalutamide alone showed a high PSA decline &gt; 50% rate, but did not achieve the pre-specified PSA threshold. Here we report patient-reported outcome data using Functional Assessment of Cancer Therapy-Prostate (FACT-P). Methods: HRQoL was measured in the overall population using the FACT-P questionnaire, comprising 5 subscales: physical wellbeing (PWB), functional wellbeing (FWB), emotional wellbeing (EWB), social/family wellbeing (SFWB), and prostate cancer subscale (PCS). Scores for each patient were measured at baseline and every four weeks until week 25. Questionnaire completion was defined as ≥ 1 question answered at an assessment time point. Analysis of HRQoL change from baseline and deterioration included only patients with baseline and ≥ 1 postbaseline score. Differences greater than 10-points in FACT-P total score and differences greater than 3-points in PWB, FWB, EWB, SFWB, and PCS scores were considered clinically significant. The time-to-event endpoint was estimated by Kaplan-Meier method and compared by stratified log-rank test. Results: 128 patients were included in LACOG0415 trial and 122 of them completed the HRQoL assessments (ranging from 95.3% at baseline to 79.7% at week 25). FACT-P and all subscales scores were similar for all three arms at baseline. There were no meaningful differences in FACT-P scores at baseline and at week 25 between the 3 arms. The subscales scores also showed no statistically differences at baseline and at week 25. Time to FACT-P deterioration did not show any statistically difference between three arms ( P=0.3371). Conclusions: ADT free alternatives with APA alone or APA+AAP did not show meaningful differences in HRQoL in patients with advanced castration-sensitive prostate cancer compared to ADT+AAP. The short follow-up period limited the ability to explore differences in HRQoL after 25 weeks. Larger studies with longer follow-up are needed to further evaluate HRQoL with ADT-free strategies. Clinical trial information: NCT02867020. [Table: see text]

Psychiatric morbidity of patients with keratoconus: A cross-sectional study

BackgroundThis study aimed to determine the prevalence of psychiatric disorders in patients with keratoconus and the effect of clinical parameters and psychiatric morbidity on quality of life in this patient group. Materials and methodsThis cross-sectional study enrolled 94 patients with keratoconus. All patients underwent a complete ophthalmic and psychiatric examination and completed the The National Eye Institute Refractive Error Quality of Life Instrument-42 (NEI-RQL-42), Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) questionnaires. The current diagnosis of psychiatric disorders was determined using the Structured Clinical Interview for DSM-IV (SCID). The impact of disease severity (binocular BCVA ≥0.4 logMAR, steep K reading ≥52, and Amsler-Krumeich grades) on vision-related quality of life was also analyzed. ResultsThe patients' mean age was 23.9 ± 4.8 (range, 18–40) years. Of the 94 participants 35 (37.2%) had a psychiatric diagnosis, 13 (13.8%) had moderate-severe depression and 20 (21.2%) had moderate-severe anxiety according to the BDI and BAI, respectively. The probability of having a psychiatric disorder was higher if the keratoconus was more severe. Patients with a psychiatric diagnosis scored lower on physical functioning, role limitations due to emotional problems, energy/fatigue; emotional well-being, social functioning and pain subscales of the Short Form-36 (SF-36). Having a SCID-1 psychiatric diagnosis and the presence of a psychiatric disorder did not significantly affect NEI-RQL-42 questionnaire scores. ConclusionsThere was high psychiatric morbidity among patients with keratoconus. Having a psychiatric disorder was associated with lower QoL as measured using the SF-36.

Epilepsy and quality of life in Iranian epileptic patients

BackgroundEpilepsy is one of the most common neurological disorders with physical, emotional, and social consequences. Previous studies indicate that epilepsy symptoms can highly affect the epileptic patients’ satisfaction in life. The aim of the present study is to investigate the QOL of People with Epilepsy (PWE) in Khorasan Razavi province, Iran.MethodsIn this study, 100 patients were randomly selected. After confirmation of the diagnosis of epilepsy by neurologists and fulfilling the entrance criteria, patients completed the Quality of Life in Epilepsy-31 inventory (QOLIE-31) questionnaire. Finally, data was analyzed statistically by SPSS software.ResultsThe study sample comprised 100 PWE, aged 18–74 years (34 ± 13), of whom 58 (58%) were females. Tonic-colonic seizure was the most common (60%) type of seizure. The obtained score of each subscale and the range of the QOLIE-31 total score was 16.40–79.18 with the mean of 50 (SD = 16). The energy-fatigue subscale score was significantly higher in patients younger than 35 (p = 0.018). The data analysis showed that the seizure worry subscale was significantly higher in single patients (p = 0.04). Duration of epilepsy had a positive correlation with QOLIE-31 total score (p = 0.038), and a negative relationship with energy-fatigue subscale (p = 0.018). In contrast with previous studies, which reported the frequency of the epileptic episodes as the most important predictor of QOL, our results showed no significant correlation between the number of the episodes and overall QOL score (p = 0.063). However, the number of episodes was significantly correlated with emotional well-being and cognition subscales. Furthermore, the results indicated that poor QOL score is correlated with depressed mood.ConclusionIn fact, the ultimate and preferred outcome of all treatments and care interventions is the patient’s QOL. Thus, improvement of the QOL by means of obtaining more information about its contributing factors, in PWE should be one of the main goals in the patients’ treatment.

Mental Well-Being of Students of Pedagogy at Ho Chi Minh City: A Cross-Sectional Study

Introduction: The well-being of students refers to the psychological, cognitive, and social functioning of the life of students. The Vietnamese undergraduate students are under a great deal of burden and pressure, that makes examining their well-being more necessary than ever. Aim: To examine the Vietnamese Pedagogy students' well-being. Materials and Methods: This was a cross-sectional study from April 2018 to September 2018, on Four hundred and seventy-six students (128 males and 348 females) at the Ho Chi Minh City University of Education on completed paper-based questionnaires that included demographic items. Our research utilised the Mental Health Continuum Short Form in Vietnamese, which surveyed Vietnamese pedagogy undergraduates. The scale was developed with an aim of creating a brief self-rating assessment tool which accesses three components of well-being: emotional, social, and psychological. The emotional well-being subscale including 3 items is defined as positive effects/satisfaction with life. Social well-being includes social contribution, social integration, social actualisation, social acceptance, and social coherence. Finally, six items represent psychological well-being: self-acceptance, environmental mastery, positive relations with others, personal growth, autonomy, and purpose in life. To achieve this goal, descriptive statistics were used for describing the sample statistics and conclusion. The Statistical Package for the Social Sciences version 16.0 was used for data analysis. Frequency, percentage, mean score, and standard deviation were used to analyse descriptive and inferential statistics. Results: A convenience sample of 476 (response rate of 600 questionnaires distributed at 79.3%) Vietnamese students from the Ho Chi Minh City University of Education was studied which included 128 males (26.9%) and 348 females (73.1%). The majority of the participants (78.6%; n=372) were born in Ho Chi Minh City, and 21.4% (n=102) were born in other provinces of Vietnam. Regarding their academic year, 50.4% (n=240), 18.9% (n=90), 13.2% (n=63) and 17.5% (n=83) were respectively represents, sophomore, junior, and senior, respectively. The results indicated that Vietnamese Pedagogy students had a high level of psychological well-being (M=2.99, SD=1.12) and emotional well-being (M=2.96, SD=1.26), while their social well-being (M=2.40, SD=1.12) was medium. Conclusion: Pedagogy students in Vietnam had a high level of psychological well-being, emotional well-being, and medium level of social well-being. All results obtained after this research are indispensable to understand the pedagogy undergraduates’ well-being. This research was conducted with the notion that it would act as a stimulant in extending related work to improve pedagogy students' well-being.

Assessment of the impact of toothache, untreated caries and its consequences on the quality of life among poor Brazilian children

Purpose: To evaluate the impact of dental pain and the consequences of untreated dental caries on the quality of life in children of low social-economic status aged from 8 to 10 years old. Materials and Methods: In this cross-sectional study, 230 children were submitted to a clinical examination in which the caries-pufa ratio was measured, afterward, they answered to two questionnaires: one about their quality of life (CPQ8-10) and the other about dental pain. Data were statistically analyzed through Chi-square, Mann-Whitney or Kruskal-Wallis tests to evaluate the association between the variables with impact on children’s OHRQoL. To establish the existence of risk factors among variables and impact on OHRQoL a Poisson Regression model was applied. Results: Dental caries (p = 0.003; PR 2.39; 95% CI 1.04–1.56), severity of untreated caries (p = 0.008; PR 2.86; 95% CI 1.13–2.00), toothache (p &lt; 0.001; PR 2.31; 95% CI 1.64–3.27) and PUFA + pufa index (p &lt; 0.023; PR 2.68; 95% CI 1.10–1.87) were associated with and were a predictor factor for impact on overall OHRQoL. All of these variables also had an effect over the social welfare subscale (p ≤ 0.001), whereas caries presence was also statistically linked with the emotional wellbeing subscale (p = 0.008) and dental pain with all four subscales (p ≤ 0.001). Conclusion: Untreated dental caries’ clinical consequences and dental pain exerted a negative influence on the quality of life of schoolchildren analyzed.

Relationship between social loneliness and dissatisfaction and family life quality in early childhood

In this study, the relationship between 66-72 months old children’s loneliness and social dissatisfaction at school and their family life quality was examined. The study included 194 kindergarten children who are 5-6 years old. As the data collection instruments, the personal information gained by the researchers, the Loneliness & Social Dissatisfaction Scale (60-72 months), and the Beach Center Family Quality of Life Scale were administered. As a result of the study, children in this sample generally reported high levels of loneliness-social dissatisfaction. A negative relationship between loneliness-social dissatisfaction of children and family quality of life was found. As a result, it was seen that the only significant predictor of loneliness and social dissatisfaction scores of children is the emotional well-being subscale. This result shows that the emotional well-being of children in the context of family life quality is the most effective factor in the loneliness and social dissatisfaction

Examination of the relationship between health-related quality of life and academic performance among student pharmacists

IntroductionA better understanding of quality of life among student pharmacists is important to enhance pharmacy education and academic performance. Study objectives were to assess associations between pre-pharmacy and demographic factors and health-related quality of life (HRQoL) among first-year (P1) and second-year (P2) pharmacy students, and to examine the relationship between HRQoL and academic performance. MethodsA survey was administered in spring 2019 to P1 (n = 201) and P2 (n = 164) students that included the RAND 36-item Health Survey 1.0 (SF-36). Data were collected from student records: demographics, undergraduate degree, undergraduate science GPA, and 2018–19 academic year GPA. Mann-Whitney U tests, Spearman rho correlational analysis, and multiple linear regression were conducted. ResultsOf 365 students, 190 (52.1%) participated. P1s versus P2s had higher scores on the SF-36 Energy/Fatigue and Social Functioning subscales (p < .001). Female students compared to male students had lower scores on the SF-36 Role Limitations-Emotional and Energy/Fatigue subscales (p < .05). Non-Hispanic white students compared to minority students had lower scores on the Role Limitations-Emotional, Energy/Fatigue, Emotional Well-being, and General Health subscales (p < .05). 2018–19 academic year GPA was positively correlated (p < .05) with scores on the Role Limitations-Emotional, Energy/Fatigue, Emotional Well-being, Social Functioning, and Pain subscales. Undergraduate science GPA and SF-36 Role Limitations-Emotional subscale were the only significant independent variables in the final multiple regression model for 2018–19 academic year GPA. ConclusionIncreased HRQoL was associated with higher GPA among P1 and P2 student pharmacists. Strategies to bolster quality of life and improve wellness among pharmacy students should be implemented and evaluated.

Impact Of A Home-based Exercise Program In Men With Prostate Cancer

PURPOSE: Physical activity after cancer diagnosis is associated with better cancer-specific and overall survival in individuals diagnosed with prostate cancer (PCa). The purpose of this study is to test the hypothesis that a home-based exercise program improves quality of life (QoL), physical fitness, and functional capacity in men with PCa under active surveillance. METHODS: A single-group, self-controlled study design was used to test the hypothesis. A total of 30 men are planned to complete the 6-month home-based exercise study. The 24-week home-based exercise program consisted of weekly light calisthenic exercise (i.e., incline pushups, body weight squats, and hip thrusts) and 150 minutes of light-to-moderate walking (monitored via FitBit). Participants completed the Short Form (SF-36) and Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) surveys. Anthropometric measurements (i.e., height, weight, and body mass index; BMI) were measured and functional exercise capacity was assessed using the 6-minute walk test (6MWT). RESULTS: At this time, five men with PCa (age: 69 ± 3; BMI: 27.4 ± 3.2) under active surveillance have completed the 24-week home-based exercise program with 100% adherence rates for weekly activity. As a result, we have observed substantial improvements in BMI (Pre: 27.4 ± 3.2; Post: 25.4 ± 2.0; -7.6%), 6MWT distance (Pre: 494.0 ± 38.3 meters; Post: 565.4 ± 8.3 meters; 14.5%) and SF-36 subscale of social functioning (Pre: 81 ± 21.3; Post: 72.5 ± 39.1; 17.2%). Modest improvements were reported for the SF-36 subscale of emotional well-being (Pre: 75.2 ± 23.7; Post: 78 ± 34.1; 3.7%) and FACIT-F subscales of functional well-being (Pre: 22.8 ± 1.3; Post: 23.5 ± 6.4; 5.9%). No other changes greater than 5% have been reported. CONCLUSIONS: This home-based exercise program was shown to be feasible with promising outcomes in body mass, physical performance and indicators of quality of life. Though it is too early to determine statistically, the results are trending towards supporting the hypothesis that a structured home-based exercise program can lower BMI and improve both QoL and functional exercise capacity.

Health-related quality of life (HRQoL) for olaparib versus enzalutamide or abiraterone in metastatic castration-resistant prostate cancer (mCRPC) with homologous recombination repair (HRR) gene alterations: PROfound.

5539 Background: In the randomized Phase III PROfound trial (NCT02987543), olaparib significantly prolonged radiographic progression-free survival compared with physician’s choice of new hormonal agent (pcNHA, enzalutamide or abiraterone) in men with mCRPC and HRR gene alterations, whose disease had progressed on prior NHA. Olaparib significantly improved time to pain progression in Cohort A. We report additional patient reported outcome measures of HRQoL in the overall study population (Cohorts A+B). Methods: HRQoL was assessed in the overall study population using the Functional Assessment of Cancer Therapy-Prostate (FACT-P) questionnaire, comprising 5 subscales: physical wellbeing (PWB), functional wellbeing (FWB), emotional wellbeing, social wellbeing, and prostate cancer subscale (PCS). The Trial Outcome Index (TOI; PWB+FWB+PCS) and FACT Advanced Prostate Symptom Index (FAPSI-6: derived from 6 FACT-P items) were also calculated. Adjusted mean change and time to deterioration in scores were statistically analyzed. Results: Baseline FACT-P total score was similar for both treatment arms. FACT-P total and subscale scores during treatment were all higher for olaparib vs pcNHA, with clinically meaningful differences between treatment arms in the adjusted least square (LS) mean changes from baseline in all but FWB and FAPSI-6 (Table). The time to deterioration in FACT-P total and TOI, FAPSI-6, PWB and PCS scores favored olaparib but were not statistically significant, with hazard ratios ranging from 0.68 to 0.94. Further HRQoL results for cohort A will also be presented. Conclusions: Olaparib delayed deterioration in HRQoL scores vs pcNHA and was associated with better HRQoL functioning over time compared with pcNHA in men with mCRPC and HRR gene alterations. Clinical trial information: NCT02987543 . [Table: see text]