Background: The coronavirus disease will worsen existing mental health disorders, and bequeath new mental health disorders on many. Our primary objective was to evaluate the prevalence of psychiatric symptoms, and identify their risk factors among people living under the COVID-19 lockdown in Lagos, Ogun, and Abuja in Nigeria. Methods: It was a cross sectional survey that was filled online. The survey collected data on socio-demography, perceived stress, social support and domestic abuse during the lockdown. Depression and post-traumatic stress disorder were measured with GHQ-12, and IES-6 respectively. Data was entered into a statistical package for sociological sciences version 23. Categorical variables were summarized. Chi square test and Fischer’s exact test were used to find association between groups. Binary regression analysis was used to identify independent predictors. p-value≤ 0∙05. Outcomes: Independent predictors for depression include, stress from home (OR- 3∙65, 95% CI- 2∙45 to 5∙49, pInterpretation: Positive health practices and innovative methods from policy makers, and the public are needed to face the threats of the pandemic.Funding Statement: The author(s) received no financial support for the research, authorship, and/or for publication.Declaration of Interests: The authors declare that they have no financial or personal relationship that may have inappropriately influenced them in writing this article. Ethics Approval Statement: Ethical approval was received from the Ethics and Research Committee of the Lagos State University Teaching Hospital, Ikeja, which conformed to the principles embodied in the Declaration of Helsinki when restriction was eased.