ABSTRACT Aim: This study aims to compare the level of stress and coping strategies among introvert and extrovert Nursing students in selected colleges of Nursing, Delhi and NCR. Design and Settings: A comparative survey design was adopted. Samples were Nursing students of Holy Family College of Nursing and Rufaida College of Nursing enrolled in B.Sc. Nursing, GNM and P.B.B.Sc. Nursing. Material and Methods: Tool was administered to 728 Nursing students through total enumeration, 200 introvert and 200 extrovert Nursing students were randomly selected through lottery method. Demographic profile, Modified Questionnaire Based on Eysenck Personality Questionnaire, Perceived Stress Scale, Brief-COPE Inventory were used to collect the data. Data was analysed with descriptive and inferential statistics. Results: Findings revealed, out of 728 Nursing students, 64.56% were introverts and 35.44% were extroverts. Mean stress score was 22.2 for introverts and 20.57 for extroverts. Among extrovert Nursing students, majority of them adopted (67.55%) problem-focused coping strategies. Whereas, 44% of introvert Nursing students adopted emotion-focused coping strategies, 40.5% adopted problem-focused coping strategies and 15.5% adopted avoidant coping strategies. The t-test value=3.102 (<0.01) for stress and coping strategies among introvert Nursing students and t-test value=3.856 (P<0.01) for stress and coping strategies among extrovert Nursing students. Hence, stress level was more among introvert Nursing students and coping strategies were more adopted by extrovert Nursing students. The correlation between stress and coping strategies among introvert Nursing students were r=0.147 (P<0.05) and r=0.246 (P<0.01) for extrovert Nursing students. Hence, it can be concluded that there is a significant difference in level of stress and coping strategies among Nursing students having introvert and extrovert personalities.