Emotional Enhancement Of Memory Research Articles

Emotional enhancement of memory for neutral information: The complex interplay between arousal, attention, and anticipation

It can be challenging to explain why certain mundane details circumstantial to an emotional event are nonetheless remembered long after the experience. Here, we examined how attention selectively shapes memory for neutral objects that happen to coincide with either an unexpected or anticipated emotional event. Pictures of neutral objects were presented for 2 s and terminated with either a high-intensity shock, a low-intensity shock, or no shock. Recognition memory was tested 24 -hs later in a surprise test. Results showed no effect of shock intensity on memory for attended objects when shocks were unpredictable (Experiment 1). Similarly, there was no effect of shock intensity for attended objects when shock delivery was signaled before the object appeared (Experiment 2). There was a reduction in memory for unattended objects paired with an anticipated high-intensity shock (Experiment 3). Finally, subjects recognized slightly more attended objects paired with a high-intensity shock if shock intensity was signaled one second after the object was encoded (Experiment 4). We conclude that simply pairing objects with high-intensity shocks is insufficient to drive episodic memory enhancements for neutral information. But anticipation of an impending source of arousal can induce bidirectional effects: attending to an impending emotional event interferes with encoding of neutral information, but encoding an object just prior to anticipation of an emotional event can sometimes benefit memory. Overall, these results highlight a complex interplay between arousal, attention, and anticipation on emotion-induced memory for neutral information.

Many ways to forget – Neurophysiology of directed forgetting mechanisms in schizophrenia

Numerous studies have shown dysfunctional mechanism of interaction between bottom-up emotional and top-down cognitive processes in persons with schizophrenia (SCZ). During the emotional directed forgetting (DF) paradigm participants have to apply volitional mechanisms to resist automatic emotional enhancement of the memory. Here we sought to compare mechanisms underlying emotional DF in SCZ and in healthy persons (HC). Eighteen SCZ and eighteen HC completed a DF paradigm with neutral and negative pictures. EEG was recorded during study and test phase of the task. We analyzed both the behavioral outcomes and event-related potential components, indicating emotional enhancement of memory (Late Positive Potential elicited by pictures) and DF strategies (N2/P3 elicited by forget/remember cues during study-phase; “old/new” and “reversed old/new” effects during test-phase of the task). Directed forgetting effects and emotional enhancement of memory were observed in both groups, even despite overall lower recognition rates in SCZ. Furthermore, cue presentation elicited similar pattern of N2/P3s in SCZ and in HC. However, “reversed old/new” effect was observed only in HC for negative stimuli. Patients may show similar reaction to affective stimuli as healthy controls during the emotional DF task. However, further investigation is needed to elicit the specific mechanisms underlying the DF strategies in SCZ.

The role of attention in immediate emotional false memory enhancement.

Two experiments examined the effect of reduced attentional resources on false memory production for emotionally valenced stimuli using the Deese/Roediger-McDermott (DRM) paradigm. Prior research has demonstrated that emotional information is often better remembered than neutral information and that enhanced memory for emotional information is dependent on either automatic or controlled neural processing (Kensinger & Corkin, 2004). Behavioral studies designed to reduce attention resources at encoding have supported neuroimaging findings that indicate high arousal negative stimuli rely more on automatic processing but positive high arousal stimuli rely more on controlled processing. No study has yet examined the attentional resources required to produce emotionally valenced false memories. In Experiment 1, negative, positive, and neutral DRM lists were studied under full or divided attention (DA) conditions, and in Experiment 2, negative and neutral DRM lists were studied under fast (20 ms) or slow (2,000 ms) presentation conditions. Under DA and speeded presentation conditions, higher false memory recognition rates were found for negative compared with positive (Experiment 1) and neutral (Experiments 1 and 2) critical lures. This is the first demonstration of which we are aware that suggests negative false memories are associated with automatic neural processing, whereas positive and nonvalenced neutral false memories are associated with more controlled processing.

Emotion effects on memory from childhood through adulthood: Consistent enhancement and adult gender differences

Emotion typically enhances memory. This “canonical” emotional memory enhancement (EME) effect has been extensively studied in adults, but its developmental trajectory is unclear. The handful of developmental studies that have manipulated emotion at encoding and then tested subsequent memory have yielded mixed results. To identify whether development change in EME occurs across middle childhood, adolescence, and early adulthood, we examined EME in 206 8- to 30-year-olds, using the same stimuli, paradigm, and analyses for all participants. At encoding, participants saw negative, neutral, and positive pictures while completing an incidental task. Two weeks later, participants completed a recognition memory test. We calculated negative–neutral and positive–neutral memory difference scores for each participant and then tested whether EME was predicted by age or gender. Negative pictures were remembered better than neutral pictures; the magnitude of this difference diminished in older male participants but not in older female ones. Positive pictures were also remembered better than neutral pictures, but this EME effect was small and did not change significantly with age or by gender. We also examined whether subjective ratings of stimulus emotion changed with age or between genders, and we report small differences. These results suggest that emotion effects on recognition memory are apparent by middle childhood and remain consistent across adolescence and early adulthood for girls and women, whereas emotion elicitation and EME effects diminish slightly with age for boys and men. These findings enrich both the EME literature specifically and what is known about emotion–cognition interactions across middle childhood, adolescence, and early adulthood more generally.

Effect of emotional enhancement of memory on recollection process in young adults: the influence factors and neural mechanisms

Emotional enhancement of memory (EEM) is thought to modulate memory recollection rather than familiarity. However, the contributing factors and neural mechanisms are not well understood. To address these issues, we investigated how valence, arousal, and the amount of devoted attention influence the EEM effect on recollection. We also compared the topological properties among hippocampus- and perirhinal and entorhinal cortex-mediated emotional memory processing networks. Finally, we evaluated the correlations between emotional memory/EEM and inherent properties (i.e., amplitude of low-frequency fluctuation and node degree, efficiency, and betweenness) of the hippocampus and perirhinal and entorhinal cortices in 59 healthy young adults by resting-state functional magnetic resonance imaging. EEM was elicited by incidental encoding, negative images, and positive high-arousal images. The hippocampus was correlated with recollection sensitivity and EEMnegative-high-arousal. The emotional memory processing network mediated by the hippocampus had higher clustering coefficient, local efficiency, and normalized characteristic path length but lower normalized global efficiency than those mediated by the perirhinal and entorhinal cortices. The entorhinal cortex was associated with both recollection and familiarity sensitivity, but showed different correlation patterns. The perirhinal cortex was highly correlated with familiarity sensitivity of negative low-arousal stimuli. These results demonstrate that the EEM effect on memory recollection is influenced by valence, stimulus arousal, and amount of attention involved during encoding. Moreover, the hippocampus and perirhinal and entorhinal cortices play distinct roles in the recollection and familiarity of emotional memory and the EEM effect.

When Do Older Adults Show a Positivity Effect in Emotional Memory?

ABSTRACTBackground: Typically, positive and negative emotional items are easier to remember than neutral ones. Charles, Mather, and Carstensen (2003) reported that older adults preferentially remember positive items, but this age-related “positivity effect” has not been replicated consistently.Methods: We conducted a close replication of Charles et al.’s study to verify that their method yields a clear positivity effect in older adults relative to the young. We also examined the role of attention, which has been argued to influence the presence of the positivity effect in older adults. We used a method similar to Charles et al. (2003). Young and older adults recalled pictures that had been encoded under full or divided attention.Results and Conclusions: Older adults showed a positivity effect, but only under full attention. Young adults did not show any hint of a positivity effect, under either of the encoding conditions. The finding of a positivity effect in older but not young adults replicates the original report from Charles et al. (2003). The attention manipulation results suggest that when the positivity effect occurs in older adults’ memory, it is attributable at least in part to cognitive control during encoding.Key terms: Emotional Enhancement of Memory–Divided attention–Aging

Neurophysiological Correlates Underlying the Influence of Divided Attention on the Emotional Memory Enhancement Effect

The aim of the study was to examine if gaze and emotional expression, both highly self-relevant social signals, affect the recollection accuracy of perceived faces in patients with mesial temporal lobe epilepsy (MTLE).Forty patients with MTLE (twenty-one without surgery and nineteen after anterior temporal lobectomy) as well as twenty healthy controls (HC) took part in the study. We used a set of 64 facial stimuli: 32 neutral and 32 emotional displays (16 fearful; 16 angry) from well-established affective stimuli databases. Half of the faces in each condition had eyes directed straight and half — away from the observer. Participants performed a gender identification task, and then, after a 45-minute delay were asked to identify the previously seen stimuli, presented among a new set of photos.Increased automatic learning of angry and fearful compared to neutral expressions was found in HC. There was no emotional enhancement of memory in MTLE but an increased learning for faces with averted than direct gaze.Our results expand on previous research by demonstrating that emotion expression and gaze direction can affect memory of faces. The study supports the hypothesis that healthy individuals and patients with temporal lobe abnormalities present different patterns of emotional gazes processing. The potential consequences of altered emotional gaze processing and social cognition impairments need to be further investigated to improve the quality of life of patients with MTLE.

Sleep-dependent enhancement of emotional memory in early childhood

Naps in early childhood support declarative memory consolidation. However, emotional memories are unique in the neural basis of encoding as well as the sleep physiology underlying consolidation. Specifically, while consolidation of declarative memories has been associated with slow wave sleep, a prevailing theory suggests that REM sleep is necessary for consolidation of memories with emotional valence. Thus, we presented children (34–64 months) with faces paired with mean or nice descriptions. There were no significant main effects of emotional valence on recognition memory. Change in memory accuracy also did not differ when probed after a nap compared to the change in memory accuracy after an interval awake. However, when memory was probed again following overnight sleep, the change in memory accuracy was greater if the child napped the previous day. Greater nap slow wave activity was associated with greater memory decay during the nap. Yet nap slow wave activity also predicted greater overnight improvement in memory. These results suggest that sleep bouts can interact to benefit memory in early childhood.

The role of the ventrolateral prefrontal cortex in emotional enhancement of memory: A TMS study

ABSTRACTNegative stimuli are often remembered better than neutral stimuli, which is called the emotional enhancement of memory (EEM). We tested whether the role of the ventrolateral prefrontal cortex (VLPFC) in the EEM depended on stimulus valence and/or arousal, and attentional resources. Continuous theta burst stimulation (cTBS) was applied over the left VLPFC, right VLPFC and vertex before encoding ‘negative arousing,’ ‘negative nonarousing,’ and ‘neutral’ words under full and divided attention, followed by a recognition test. The vertex condition showed the EEM effect for ‘negative arousing’ and ‘negative nonarousing’ words. However, the right VLPFC condition showed no evidence of the EEM effect for ‘negative arousing’ or ‘negative nonarousing’ words, under full attention. In contrast, the left VLPFC condition showed the EEM effect for ‘negative arousing’ words, but not ‘negative nonarousing’ words, under full attention. Thus, the left and right VLPFC have different roles in the EEM, depending on valence and arousal.

Dissociable contributions of the amygdala to the immediate and delayed effects of emotional arousal on memory.

Emotional arousal enhances memory encoding and consolidation leading to better immediate and delayed memory. Although the central noradrenergic system and the amygdala play critical roles in both effects of emotional arousal, we have recently shown that these effects are at least partly independent of each other, suggesting distinct underlying neural mechanisms. Here we aim to dissociate the neural substrates of both effects in 70 female participants using an emotional memory paradigm to investigate how neural activity, as measured by fMRI, and a polymorphism in the α2B-noradrenoceptor vary for these effects. To also test whether the immediate and delayed effects of emotional arousal on memory are stable traits, we invited back participants who were a part of a large-scale behavioral memory study ∼3.5 yr ago. We replicated the low correlation of the immediate and delayed emotional enhancement of memory across participants (r = 0.16) and observed, moreover, that only the delayed effect was, to some degree, stable over time (r = 0.23). Bilateral amygdala activity, as well as its coupling with the visual cortex and the fusiform gyrus, was related to the preferential encoding of emotional stimuli, which is consistent with affect-biased attention. Moreover, the adrenoceptor genotype modulated the bilateral amygdala activity associated with this effect. The left amygdala and its coupling with the hippocampus was specifically associated with the more efficient consolidation of emotional stimuli, which is consistent with amygdalar modulation of hippocampal consolidation.

Dissociation of immediate and delayed effects of emotional arousal on episodic memory.

Emotionally arousing events are usually better remembered than neutral ones. This phenomenon is in humans mostly studied by presenting mixed lists of neutral and emotional items. An emotional enhancement of memory is observed in these studies often already immediately after encoding and increases with longer delays and consolidation. A large body of animal research showed that the more efficient consolidation of emotionally arousing events is based on an activation of the central noradrenergic system and the amygdala (Modulation Hypothesis; Roozendaal & McGaugh, 2011). The immediately superior recognition of emotional items is attributed primarily to their attraction of attention during encoding which is also thought to be based on the amygdala and the central noradrenergic system. To investigate whether the amygdala and noradrenergic system support memory encoding and consolidation via shared neural substrates and processes a large sample of participants (n = 690) encoded neutral and arousing pictures. Their memory was tested immediately and after a consolidation delay. In addition, they were genotyped in two relevant polymorphisms (α2B-adrenergic receptor and serotonin transporter). Memory for negative and positive emotional pictures was enhanced at both time points where these enhancements were correlated (immediate r = 0.60 and delayed test r = 0.46). Critically, the effects of emotional arousal on encoding and consolidation correlated only very low (negative r = 0.14 and positive r = 0.03 pictures) suggesting partly distinct underlying processes consistent with a functional heterogeneity of the central noradrenergic system. No effect of genotype on either effect was observed.

Local context influences memory for emotional stimuli but not electrophysiological markers of emotion-dependent attention.

Emotional enhancement of free recall can be context dependent. It is readily observed when emotional and neutral scenes are encoded and recalled together in a “mixed” list, but diminishes when these scenes are encoded separately in “pure” lists. We examined the hypothesis that this effect is due to differences in allocation of attention to neutral stimuli according to whether they are presented in mixed or pure lists, especially when encoding is intentional. Using picture stimuli that were controlled for semantic relatedness, our results contradicted this hypothesis. The amplitude of well‐known electrophysiological markers of emotion‐related attention—the early posterior negativity (EPN), the late positive potential (LPP), and the slow wave (SW)—was higher for emotional stimuli. Crucially, the emotional modulation of these ERPs was insensitive to list context, observed equally in pure and mixed lists. Although list context did not modulate neural markers of emotion‐related attention, list context did modulate the effect of emotion on free recall. The apparent decoupling of the emotional effects on attention and memory, challenges existing hypotheses accounting for the emotional enhancement of memory. We close by discussing whether findings are more compatible with an alternative hypothesis, where the magnitude of emotional memory enhancement is, at least in part, a consequence of retrieval dynamics.

Effect of cortisol diurnal rhythm on emotional memory in healthy young adults

Few studies have investigated the relationship between cortisol diurnal rhythm and cognitive function in healthy young adults, especially for emotional memory. To address this deficiency, this study examined the effect of diurnal cortisol slope (DCS) and heart rate variability (HRV) on emotional memory. Participants included healthy volunteers (44 men and 23 women; mean age 20.60 yrs). Participants were shown emotionally arousing slides and were asked to return to the laboratory one week later where they were given a “surprise” memory test to examine their emotional memory retention. Participants were asked to collect saliva samples at four time points (08:00, 11:00, 15:00, and 20:00) on the experimental days; these samples were used to calculate the DCS. Moreover, HRV was measured during the experiment. The multiple linear regression analysis revealed that declarative memory ability, sleep duration, and the DCS were the final significant determinants for emotional memory enhancement (B = −20.41, 0.05, −48.20, ps < 0.05), with participants having flatter cortisol slopes showing reduced or absent emotional memory enhancement. These findings are discussed in reference to the possible effects of diurnal rhythm mechanisms of the hypothalamus-pituitary-adrenal axis and the autonomic nervous system on emotional memory.

Noradrenergic activation of the basolateral amygdala maintains hippocampus-dependent accuracy of remote memory

Emotional enhancement of memory by noradrenergic mechanisms is well-described, but the long-term consequences of such enhancement are poorly understood. Over time, memory traces are thought to undergo a neural reorganization, that is, a systems consolidation, during which they are, at least partly, transferred from the hippocampus to neocortical networks. This transfer is accompanied by a decrease in episodic detailedness. Here we investigated whether norepinephrine (NE) administration into the basolateral amygdala after training on an inhibitory avoidance discrimination task, comprising two distinct training contexts, alters systems consolidation dynamics to maintain episodic-like accuracy and hippocampus dependency of remote memory. At a 2-d retention test, both saline- and NE-treated rats accurately discriminated the training context in which they had received footshock. Hippocampal inactivation with muscimol before retention testing disrupted discrimination of the shock context in both treatment groups. At 28 d, saline-treated rats showed hippocampus-independent retrieval and lack of discrimination. In contrast, NE-treated rats continued to display accurate memory of the shock-context association. Hippocampal inactivation at this remote retention test blocked episodic-like accuracy and induced a general memory impairment. These findings suggest that the NE treatment altered systems consolidation dynamics by maintaining hippocampal involvement in the memory. This shift in systems consolidation was paralleled by time-regulated DNA methylation and transcriptional changes of memory-related genes, namely Reln and Pkmζ, in the hippocampus and neocortex. The findings provide evidence suggesting that consolidation of emotional memories by noradrenergic mechanisms alters systems consolidation dynamics and, as a consequence, influences the maintenance of long-term episodic-like accuracy of memory.

Gaze matters! The effect of gaze direction on emotional enhancement of memory for faces in patients with mesial temporal lobe epilepsy

The aim of the study was to examine if gaze and emotional expression, both highly self-relevant social signals, affect the recollection accuracy of perceived faces in patients with mesial temporal lobe epilepsy (MTLE). Forty patients with MTLE (twenty-one without surgery and nineteen after anterior temporal lobectomy) as well as twenty healthy controls (HC) took part in the study. We used a set of 64 facial stimuli: 32 neutral and 32 emotional displays (16 fearful; 16 angry) from well-established affective stimuli databases. Half of the faces in each condition had eyes directed straight and half - away from the observer. Participants performed a gender identification task, and then, after a 45-minute delay were asked to identify the previously seen stimuli, presented among a new set of photos. Increased automatic learning of angry and fearful compared to neutral expressions was found in HC. There was no emotional enhancement of memory in MTLE but an increased learning for faces with averted than direct gaze. Our results expand on previous research by demonstrating that emotion expression and gaze direction can affect memory of faces. The study supports the hypothesis that healthy individuals and patients with temporal lobe abnormalities present different patterns of emotional gazes processing. The potential consequences of altered emotional gaze processing and social cognition impairments need to be further investigated to improve the quality of life of patients with MTLE.

Relationship between cerebellar structure and emotional memory in depression.

BackgroundA few studies have been conducted on the relationship between cerebellar volume and emotional memory or clinical severity in major depressive disorder (MDD). In this study, we aimed to compare the volume and density of the cerebellar gray matter (GM) in patients with MDD and in healthy controls (HCs) and explore the association between these cerebellar parameters and measurements of emotional memory and clinical severity.MethodVoxel‐based morphometry (VBM) and Individual Brain Atlases using Statistical Parametric Mapping (IBASPM) were used to assess GM density and volume in the cerebellum, respectively, in patients with MDD and the HCs. Indicators of emotional memory performance were measured, including the hit rate (HR), rate of false alarm (FA), precision (Pr = HR − FA) and emotional memory enhancement [∆Pr = Pr(emotion) − Pr(neutral)] values. Beck Depression Inventory (BDI) scores were used to measure the severity of depression.ResultsIn the patients with MDD, the GM density was decreased in three cerebellar cortical regions and increased in three cerebellar cortical regions (p < .005). The GM volumes in eight cerebellar cortical regions were significantly smaller in the patients with MDD than in the HC subjects (p < .05). In the patients with MDD, the GM volume was correlated with the ∆Pr (p < .05) in two cerebellar cortical regions. The BDI scores were significantly correlated with the relative GM densities (p < .05) in 5 cerebellar cortical regions, and the GM volumes in 13 cerebellar cortical regions were correlated with the BDI scores in patients with MDD.ConclusionsEmotional memory and the severity of depressive symptoms are associated with structural changes in both the posterior and anterior GM regions in the cerebellum in patients with MDD. These findings could be useful for improving our understanding of the neurobiological mechanisms underlying emotional memory and explaining the abnormalities of the neural correlates that are associated with MDD.

General and emotion-specific neural effects of ketamine during emotional memory formation

Animal studies suggest that N-methyl-D-aspartate receptor (NMDAR) dependent signalling in limbic and prefrontal regions is critically involved in both cognitive and emotional functions. In humans, ketamine-induced transient, and disorder associated chronic NMDAR hypofunction (i.e. in schizophrenia) has been associated with deficient performance in the domains of memory and higher-order emotional functioning, as well as altered neural activity in the underlying limbic-prefrontal circuits. To model the effects of NMDAR hypofunction on the integration of emotion and cognition the present pharmacological fMRI study applied the NMDAR antagonist ketamine (target plasma level=100ng/ml) to 21 healthy volunteers in a within-subject placebo-controlled crossover design during encoding of neutral, positive and negative pictures. Our results show that irrespective of emotion, ketamine suppressed parahippocampal and medial prefrontal activity. In contrast, ketamine selectively increased amygdala and orbitofrontal activity during successful encoding of negative stimuli. On the network level ketamine generally increased medial prefrontal-parahippocampal coupling while specifically decreasing amygdala-orbitofrontal interplay during encoding of negative stimuli. On the behavioural level, ketamine produced generally decreased memory performance and abolished the emotional enhancement of memory after a wash-out period of 5 days. The present findings suggest that ketamine produces general as well as valence-specific effects during emotional memory formation. The pattern partly overlaps with alterations previously observed in patients with schizophrenia.

Negative Bias in the Perception and Memory of Emotional Information in Alzheimer Disease.

There is some controversy about the ability of patients with Alzheimer disease (AD) to experience and remember emotional stimuli. This study aims to assess the emotional experience of patients with AD and the existence of emotional enhancement of memory. We also investigated the influence of affective state on these processes. Sixty pictures from the International Affective Picture System were administered to 106 participants (72 patients with AD and 54 controls). Participants performed immediate free recall and recognition tasks. Positive and Negative Affect Schedule was used to assess the participants' current affect. Patients identified the valence of unpleasant pictures better than of others pictures and experienced them as more arousing. Patients and controls recalled and recognized higher number of emotional pictures than of neutral ones. Patients discriminated better the unpleasant pictures. A mood congruent effect was observed on emotional experience but not on memory. Positive affect was associated with better immediate recall and with a more liberal response bias. Patients with AD can identify the emotional content of the stimuli, especially of the unpleasant ones, and the emotional enhancement of memory is preserved. Affective state does not explain the differences in the processing and memory of emotional items between patients and controls.

Recognition memory for low- and high-frequency-filtered emotional faces: Low spatial frequencies drive emotional memory enhancement, whereas high spatial frequencies drive the emotion-induced recognition bias.

This article deals with two well-documented phenomena regarding emotional stimuli: emotional memory enhancement-that is, better long-term memory for emotional than for neutral stimuli-and the emotion-induced recognition bias-that is, a more liberal response criterion for emotional than for neutral stimuli. Studies on visual emotion perception and attention suggest that emotion-related processes can be modulated by means of spatial-frequency filtering of the presented emotional stimuli. Specifically, low spatial frequencies are assumed to play a primary role for the influence of emotion on attention and judgment. Given this theoretical background, we investigated whether spatial-frequency filtering also impacts (1) the memory advantage for emotional faces and (2) the emotion-induced recognition bias, in a series of old/new recognition experiments. Participants completed incidental-learning tasks with high- (HSF) and low- (LSF) spatial-frequency-filtered emotional and neutral faces. The results of the surprise recognition tests showed a clear memory advantage for emotional stimuli. Most importantly, the emotional memory enhancement was significantly larger for face images containing only low-frequency information (LSF faces) than for HSF faces across all experiments, suggesting that LSF information plays a critical role in this effect, whereas the emotion-induced recognition bias was found only for HSF stimuli. We discuss our findings in terms of both the traditional account of different processing pathways for HSF and LSF information and a stimulus features account. The double dissociation in the results favors the latter account-that is, an explanation in terms of differences in the characteristics of HSF and LSF stimuli.

Impaired White Matter Connections of the Limbic System Networks Associated with Impaired Emotional Memory in Alzheimer's Disease.

Background: Discrepancies persist regarding retainment of emotional enhancement of memory (EEM) in mild cognitive impairment (MCI) and early Alzheimer's disease (AD) patients.In addition, the neural mechanisms are still poorly understood, little is known about emotional memory related changes in white matter (WM).Objective: To observe whether EEM is absent in amnestic MCI (aMCI) and AD patients, and to investigate if emotional memory is associated with WM connections and gray matters (GM) of the limbic system networks.Methods: Twenty-one AD patients, 20 aMCI patients and 25 normal controls participated in emotional picture recognition tests and MRI scanning. Tract-based spatial statistics (TBSS) and voxel-based morphometry (VBM) methods were used to determine white and gray matter changes of patients. Fourteen regions of interest (ROI) of WM and 20 ROIs of GM were then selected for the correlation analyses with behavioral scores.Results: The EEM effect was lost in AD patients. Both white and gray matter of the limbic system networks were impaired in AD patients. Significant correlations or tendencies between the bilateral uncinate fasciculus, corpus callosum (genu and body), left cingulum bundle, left parahippocampal WM and the recognition sensitivity of emotional valence pictures, and significant correlations or tendencies between the splenium of corpus callosum, left cingulum bundle, left crus of fornix and stria terminalis and the recognition sensitivity of EEM were found. The volume of left amygdala, bilateral insula, medial frontal lobe, anterior and middle cingulum gyrus were positively correlated with the recognition sensitivity of emotional photos, and the right precuneus was positively correlated with the negative EEM effect. However, the affected brain areas of aMCI patients were more localized, and aMCI patients benefited only from positive stimuli.Conclusion: There are impairments of the limbic system networks of AD patients. Damaged WM connections and GM volumes of those networks are associated with impaired emotional memory and EEM effect in AD patients.