Emotional Disorders In Patients Research Articles

Effectiveness of adaptol in the treatment of emotional disorders in patients with physical illnesses

Effectiveness of adaptol in the treatment of emotional disorders in patients with physical illnesses

Cognitive and Emotional Disorders in Patients with Migraine and Signs of Leukoencephalopathy

Cognitive and Emotional Disorders in Patients with Migraine and Signs of Leukoencephalopathy

A preliminary examination of unified protocol for transdiagnostic treatment of emotional disorders in patients with panic disorder: a single-case experimental design in Iran

ABSTRACT Background and Objectives The majority of patients suffering from anxiety disorders in low- and middle-income countries do not receive evidence-based treatments. The Unified Protocol (UP) for the Transdiagnostic Treatment of Emotional Disorders is an evidence-based cognitive–behavioral intervention designed to treat the range of emotional disorders. Design and Methods Using a single-case experimental design five patients with panic disorder were assigned to a 3-week baselines assessment phase followed by eight sessions of UP treatment and 4-week follow-up phases. Multiple outcome measures of panic severity, anxiety sensitivity, affectivity, and overall anxiety severity and impairment were administered weekly during the baseline, intervention, and follow-up phases. Results At post treatment, all participants showed significant reductions in outcome measures, with changes functionally related to treatment and most improvements maintained at 4-week follow-up. Conclusion Findings provide preliminary cross-cultural support for UP and add to the growing body of literature showing UP can be useful for patients with anxiety disorders in low- and middle-income countries with non-Western cultures.

Патогенетичні аспекти превентивної корекції когнітивних порушень при метаболічному синдромі

Мета. Вивчити можливості збільшення ефективності патогенетичної терапії пацієнтів з хронічними цереброваскулярними захворюваннями (ЦВЗ) (дисциркуляторна енцефалопатія, ДЕ) на фоні метаболічного синдрому (МС) з використанням препарату Вітаксон®. Особливістю роботи було виявлення стратегічних ділянок мозку при когнітивних та емоційних розладах у пацієнтів з МС та за його відсутності. Матеріали та методи. Спостерігали 49 пацієнтів з ДЕ ІІ ст. віком від 37 до 73 років на фоні МС. Основна група — 30 пацієнтів — у складі лікування отримувала препарат Вітаксон®. Контрольна група становила 19 пацієнтів з ДЕ ІІ ст. на фоні МС, порівнянних за віком і стадією захворювання, які не приймали препарат Вітаксон®. Пацієнтів спостерігали протягом 12 тижнів. Крім неврологічних, загальноклінічних обстежень, визначення ознак МС, застосовували нейропсихологічне тестування за шкалою Mini Mental State Examination (MMSE) та шкалою оцінки когнітивних функцій Montreal Cognitive Assessment (МоСА), шкалою тривоги Спілбергера; шкалою депресії Бека; дослідження уваги: пошук чисел за таблицями Шульте з оцінкою часу виконання завдання. Головний мозок і його лікворну систему у 41 пацієнта (27 пацієнтів з МС — перша група та 14 пацієнтів без МС — друга група) оцінювали за допомогою методу волюметрії (вимірювання об’ємів окремих ділянок мозку) на МРТ-сканері Toshiba Vantage Titan 1,5. Результати. Когнітивні порушення в обох групах проявлялись у зниженні пам’яті, порушенні уваги, уповільненні психічних процесів. На 12-му тижні медіана за шкалою ММSE вірогідно збільшилась на 3,3 % (р < 0,05 порівняно з першим тестуванням) у групі пацієнтів, які приймали препарат Вітаксон®. За шкалою МоСА, що чутливіша при визначенні легких когнітивних порушень, у групі, де пацієнти приймали препарат Вітаксон®, когнітивні функції покращились на 5 %, а в групі контролю — на 1,66 %. За шкалою Спілбергера показники реактивної тривожності покращились більше в тій групі, де пацієнти приймали досліджуваний препарат; на початку лікування — 42,4 ± 3,4 бала та 24,6 ± 2,8 бала на 12-му тижні (р < 0,05). Було визначено, що показники когнітивної функції за шкалою МоСА обернено залежні від показників глікованого гемоглобіну. Результати волюметричних досліджень показали вірогідне (р < 0,05) зменшення об’єму речовини мозку, об’єму кори та білої речовини великих півкуль мозку, скроневої частки у пацієнтів з ЦВЗ на фоні МС порівняно з пацієнтами аналогічного віку без ознак МС. Крім того, у пацієнтів з МС визначалось вірогідне зменшення площі мозолистого тіла (р < 0,05) порівняно з пацієнтами без МС. Висновки. При лікуванні пацієнтів з ЦВЗ на фоні МС слід ураховувати тривожно-астенічні стани та когнітивні порушення, що часто виникають при цій патології. Додавання до загальноприйнятої терапії препарату Вітаксон® сприяє відновленню психоемоційних розладів. У пацієнтів з хронічними ЦВЗ на фоні МС ступінь атрофії кори та білої речовини великих півкуль мозку, лобної та скроневої часток, а також мозолистого тіла визначався вірогідно більшим (р < 0,05) порівняно з хворими без МС.

Study of emotional disorders in dermatological and cardiological patients

Objective. To study the character and features of emotional disorders in patients of dermatological and cardiological profile. Emotional changes, accompanying many somatic diseases, have a negative effect and aggravate their course, worsening the quality of life and functioning. Materials and methods. 68 persons, divided into two groups, participated in a single-stage study: group I included 38 patients with dermatoses without any concomitant diseases of the internal organs; group II 30 cardiological patients without dermatological pathology in anamnesis. Complex research included general clinical and laboratory methods as well as psychological study using the Hospital Anxiety and Depression Scale HADS, Zung Self-Rating Depression Scale, Montgomery Asberg Depression Scale, Spielberger Hanin Anxiety Scales. To assess the results, the methods of parametric and nonparametric statistics were used. Results. When assessing the parameters by the Hospital Anxiety and Depression Scale HADS, in dermatological patients clinically and subclinically expressed anxiety was manifested more evidently, and in cardiological patients, it was depression. According to the data obtained by the Zung and Hamilton scales, depression also predominated in cardiological patients but anxiety symptoms and disorders reliably more often were observed in patients of dermatological profile. As for studying depression using the Montgomery-Asberg scale, in dermatological patients it was revealed less often, in the structure of symptoms there prevailed a small depressive episode. According to Spielberger Hanin Scale, anxiety was more expressed in dermatological patients. Conclusions. Emotional disorders in dermatological and cardiological patients are reliably different. In dermatological patients, they are characterized by increased anxiety in case of an insignificant depressive disorder. In cardiological patients, there prevail depressive changes, especially mild depression; anxiety symptomatology is not expressed.

Neurological and cognitive sequelae of Covid-19: a four month follow-up.

Central and peripheral nervous system involvement during acute COVID-19 is well known. Although many patients report some subjective symptoms months after the infection, the exact incidence of neurological and cognitive sequelae of COVID-19 remains to be determined. The aim of this study is to investigate if objective neurological or cognitive impairment is detectable four months after SARS-CoV-2 infection, in a group of patients who had mild–moderate COVID-19. A cohort of 120 health care workers previously affected by COVID-19 was examined 4 months after the diagnosis by means of neurological and extensive cognitive evaluation and compared to a group of 30 health care workers who did not have COVID-19 and were similar for age and co morbidities. At 4 month follow-up, 118/120 COVID-19 cases had normal neurological examination, two patients had neurological deficits. COVID-19 patients did not show general cognitive impairment at MMSE. In COVID-19 cases the number of impaired neuropsychological tests was not significantly different from non COVID-19 cases (mean 1.69 and 1 respectively, Mann–Whitney p = n.s.), as well as all the mean tests’ scores. Anxiety, stress and depression scores resulted to be significantly higher in COVID-19 than in non COVID-19 cases. The results do not support the presence of neurological deficits or cognitive impairment in this selected population of mild–moderate COVID-19 patients four months after the diagnosis. Severe emotional disorders in patients who had COVID-19 in the past are confirmed.

Transdiagnostic Versus Construct-Specific Cognitive Behavioural Therapy for Emotional Disorders in Patients with High Anxiety Sensitivity: A Double-Blind Randomised Clinical Trial

AbstractAnxiety sensitivity (AS) is a common vulnerability in emotional disorders. Due to the pathological role of AS, individuals with high AS are faced with emotional problems. Thus, cognitive behavioural interventions try to reduce these problems by targeting AS. The present study aimed to compare the efficacy of transdiagnostic cognitive behavioural therapy (T-CBT) and construct-specific CBT (CS-CBT) on AS, anxiety, depression, and positive and negative affect in these patients. To this end, 40 patients with high AS were randomly assigned to one of the three groups of T-CBT, CS-CBT, and wait list. Participants were assessed using the Anxiety and Related Disorders Interview Schedule for the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Anxiety Sensitivity Index-3, Beck Anxiety Inventory, Beck Depression Inventory-II, and Positive and Negative Affect Schedule at baseline, post-treatment, 3-month follow-up, and 6-month follow-up. The findings showed that T-CBT and CS-CBT have a significant effect on AS, anxiety, and negative affect; however, contrary to T-CBT, CS-CBT is not effective for reducing depression and positive affect. T-CBT had a more promising efficacy than CS-CBT in all treatment outcomes. The results show better and more stable efficacy of T-CBT among patients with high AS. It is essential to consider AS as a target for cognitive behavioural intervention for the spectrum of emotional disorders.

Emotional disorder: a neglected symptoms of chronic liver disease

Patients with chronic liver disease generally have emotional disorders that typically manifest as depression, and seriously affects the quality of life. The mechanism of emotional disorders in patients with chronic liver disease is unclear, and may be related to variety of factors such as disease type, etiological treatment, economic, social support, and an individual psychology. Moreover, emotional disorders in patients with chronic liver disease can be assessed on a variety of scales and managed comprehensively through non-drug and drug therapy. This article reviews the potential pathogenesis, evaluation and treatment methods, in order to improve and provide more help for its effective treatment.

Complex approach to correction of emotional disorders in patients with type II diabetes using biosuggestive therapy

Effective therapy of psychosomatic diseases in the classical sense of this term (bronchial asthma, diabetes mellitus, arterial hypertension, etc.) is an important problem due to the high frequency of chronic course, increase in the incidence and prevalence of this pathology. Patients with diabetes mellitus and anxiety-depressive disorders primarily need psychotherapeutic correction of the emotional state in connection with the possibility of a more significant positive effect on the quality of life, performance of patients and facilitating the further course of psychosomatic diseases. A comprehensive clinical, psychopathological and psychodiagnostic examination was conducted in 109 patients with type II diabetes mellitus and comorbid emotional disorders, both sexes at the age of (35.9±10.1) years. The main group consisted of 65 patients, along with the standard treatment, according to clinical protocols, they received a course of biosuggestive therapy, the control group consisted of 44 patients, who received standard therapy, according to clinical protocols. Using biosuggestive therapy in the complex treatment of patients with emotional disorders in type II diabetes mellitus has a positive effect on the feeling of psychological well-being, improving interpersonal relationships, enhancing a sense of belonging and personal fulfillment, which, in turn, affects the general perception of the quality of life, and most importantly decreases the main symptoms and the level of neuropsychic stress. This study proved high efficiency of biosuggestive therapy using in the complex treatment approach of emotional disorders in patients with type II diabetes mellitus, namely, there is a decrease in anxiety-depressive symptoms, restoration of working capacity and social activity, a decrease in the level of neuropsychic stress, normalization of the sleep-wake cycle, improvement quality of life of the examined patients. Keywords: type II diabetes, emotional disorders, correction, psychotherapy.

Evaluation of kidney function in older adults

The evaluation of renal function in older adults is usually carried out with a creatinine clearance or an estimation of glomerular filtration rate using formulas such as Cockcroft-Gault, MDRD or CKD-EPI. The results obtained with these formulas are often regarded as equivalent. However, in adults older than 70 years, the Cockcroft-Gault formula frequently underestimates the glomerular filtration rate with respect to reference methods and the MDRD formula overestimates it. CKD-EPI has a more unpredictable behavior. This leads to erroneously classifying patients in the stages of chronic kidney disease (CKD), artificially increasing the prevalence of this condition, overloading health systems and generating emotional disorders in patients mistakenly classified as carriers of CKD. Also, when kidney function is overestimated, CKD patients are prevented from receiving the treatments appropriate for their condition. In recent years, new formulas have been proposed (FAS, BIS) with a greater accuracy to estimate glomerular filtration rate in older adults. This review describes the behavior of these formulas in a significant number of older adults, from various countries, and proposes using those equations with the best performance in older adults.

The effectiveness of complex medical and psychological rehabilitation of women in the menopausal period

Study of the complex medical methods' effectiveness and psychological rehabilitation of patients during menopause with the use of psychophysiological programs and certain psychotherapy techniques. The study included 90 women in menopause. The average age of the patients was 55.0±7.4 years. All patients were divided into 3 groups. In the 1st (30 menopause patients, average age 53.0±4.4 years) and 2nd (30 menopause patients with cancer or osteoporosis, average age 57.0±5.15 years) complex medical and psychological rehabilitation, including, in addition to drug therapy, physiotherapy procedures, manual therapy, psychophysiological and psychotherapeutic procedures were used. In the 3rd control group (30 patients, mean age 56.0±9.6 years), drug therapy, physiotherapy procedures and manual therapy were used. The analysis of the obtained data revealed the emotional disorders in patients of the 1st and 2nd groups before rehabilitation. There were low and decreased values of the subjective comfort index, SCI (31.4±5.12-40.7±5.21 points); high degree of fatigue reflecting a pronounced and strong degree of chronic fatigue, CF (27.00±3.53-41.40±6.12 points), high values of the personal anxiety indicator, PA (47.6±3.52-55, 1±5.91 points).After a complex medical and psychological care in patients of the 1st and 2nd groups the indicators characterizing the emotional and personal sphere improved significantly (p<0.05). The trial aimed to study the effectiveness of the complex medical and psychological rehabilitation of women during menopause showed a change in the indicators of the emotional and personal sphere after psychophysiological and psychotherapeutic influence, an improvement in the emotional state of patients and the life quality.

Cognitive and emotional disorders in patients with migraine and signs of leukoencephalopathy

To identify cognitive and emotional disorders and their correlation with neuroimaging parameters in patients with chronic migraine. We examined 50 patients (8 men and 42 women, mean age 41.9±11.9 years) with migraine, including 31 with chronic migraine, and signs of leukoencephalopathy according to magnetic resonance imaging (MRI). A control group comprised 40 healthy individuals (13 men and 27 women) aged 20 to 64 years (mean 42.6±12.0 years). A number of tests for neuropsychological examination and assessment of the emotional state, including a 12-word test, literal and categorical associations, Benton Test, the Montreal cognitive scale (MOCA), the Hospital Depression Scale, the Beck Depression Scale, the Center for Epidemiological Research scale, the Hospital Anxiety Scale and the Spielberger-Khanin scale, were administered at baseline and after 3 and 6 month of preventive therapy. Patients with migraine had lower scores (p=0.004) on MOCA, memorization of 12 words (p=0.0003), test for literal (p=0.001) and categorical associations (p=0.0002) compared with the control group. No significant correlations were found between the volume of white matter lesions according to MRI and the severity of cognitive impairment. An inverse correlation of average strength was noted (correlation coefficient R=-0.41) between the number of days with headache per month and the MOCA score (p<0.05). In patients with migraine, signs of depression were found on the Hospital Depression Scale (p=0.04), Beck Depression Scale (p=0.003), the Center for Epidemiological Research scale (p=0.0001), and increased anxiety on the Hospital Anxiety Scale (p=0.0001) and the Spielberger-Khanin scale (p=0.0001). A significant relationship was found between the degree of depression and the MOCA score (p=0.007). The frequency of headaches decreased from 19.4±2.9 to 12.6±4.4 days per month (p<0.05). There were a significant decrease of emotional disorders and improvement of cognitive functions compared with baseline scores during the 6 month therapy. Preventive treatment of migraine and concomitant emotional disorders seems to be the most effective way to improve cognitive functions.

Emotional disorders in patients with motor neuron disease in the Republic of Sakha (Yakutia)

Emotional disorders in patients with motor neuron disease in the Republic of Sakha (Yakutia)

The effect of acupuncture on emotional disorders in patients with insomnia: A protocol for systemic review and meta-analysis.

Background:Insomnia with high incidence is usually accompanied by many other diseases, especially mental disorders with the under-diagnosis and under-treatment. Some studies demonstrated that acupuncture may be effective for emotional disorders accompanied by insomnia. The systematic review protocol is designed to guiding analysis the effectiveness and safety of acupuncture for emotional disorders in patients with insomnia.Methods:Seven databases, Cochrane central register of controlled trials, Medline, Embase, China National Knowledge Infrastructure, Chinese Biomedical Literature database, VIP database and Wanfang database, will be searched from initial to December 2020. Randomized controlled trials (RCTs) of acupuncture for insomnia with emotional disorders (depression and anxiety) outcomes, which were reported in Chinese or English, will be included. The primary outcome is the change of degree of anxiety and depression. Study selection, data extraction and assessment of the risk of bias will be performed independently by 2 or more reviewers. Available data will be synthesized and statistically analyzed in RevMan V.5.3. The model of fixed effects will be used for the pooled data when the heterogeneity tests show little or no statistical heterogeneity (I2 < 50%). The random-effects model will be taken with heterogeneous data (50% ≤ I2 < 75%).Results:The effect of acupuncture on emotional disorders in patients with insomnia will be assessed on Hamilton anxiety Scale, Hamilton anxiety Scale, Pittsburgh Sleep Quality Index, Insomnia Severity Index, Self-rating Anxiety Scale, Self-rating Depressive Scale and the number of participants secede and the number of patients reported adverse events.Conclusion:the emotional disorders interaction with insomnia and the increase of risk on disease evolving and insomnia-related burden, it is so momentous to know that the role of insomnia treatment on comorbidities. We should concern about the management of emotional disorders when treat insomnia, and acupuncture treatment anxiety and depression caused by insomnia may be effective.Ethics and dissemination:Ethics approval is not be needed because the data will not contain individual patient data, and there are no concerns about privacy. The results of this meta-analysis will be disseminated through publication in a peer-reviewed academic journal or relevant conference.INPLASY registration number:INPLASY2020100115.

Prevalence and association of anxiety and depression among orthopaedic trauma inpatients: a retrospective analysis of 1994 cases

BackgroundPatients with traumatic injuries are often accompanied by emotional disorders, which seriously impede functional gains. The objective of this study was to identify the prevalence and risk factors associated with underlying anxiety and depression in orthopaedic trauma patients.MethodsFrom July 2015 to December 2017, all orthopaedic trauma patients were included in the retrospective study. Patients with conditions that might affect cognitive impairment were excluded from the study. Basic demographic data were collected. All patients were screened for emotional disorders on admission using a simple questionnaire called “Huaxi Emotional-Distress Index” (HEI). Bivariate analyses and logistic regression were used to identify the factors associated with a HEI score of > 8.ResultsOne hundred and sixty-two patients (8.1%) had a HEI score of > 8. About 1.0% of enrolled patients had severe emotional disorders (HEI score ≥ 17). The reasons caused by emotional disorders in patients with orthopaedic trauma were a higher Injury Severity Score (ISS), a higher visual analogue score (VAS) and type of surgery. On logistic regression, marital status was a protective factor for emotional disorders, while VAS and ISS were the risk factors for emotional disorders.ConclusionsAlthough a significantly low percentage of orthopaedic trauma patients in our setting have emotional disorders, traumatic orthopaedic surgeons still need to pay attention to the risk of emotional disorders and integrate effective screening tools into clinical practice to screen for these factors and stratify emotional disorders. Appropriate targeted psychological intervention and treatment should be adopted according to the stratification of emotional disorders.

Analysis of the relationship between skin and emotional disorders in patients with psoriasis

107 patients (34 female and 73 male) diagnosed with “generalized psoriasis vulgaris, exudative form, progressive stage” were evaluated for the levels of anxiety and depression. These measurements were carried out along with psychiatrist interview, taking into consideration anamnestic and status information. 67,3% of patients unhesitatingly marked that a previous psychological trauma had caused the current exacerbation of psoriasis. The study reveals interrelationship between the psychiatric and somatic components of psoriasis. We managed to reach marked remission in 19 patients using low doses of psychotropic drugs along with primary dermatological treatment.

Structure of risk factors, comorbid conditions and emotional disorders in patients with myocardial infarction with atrial fibrillation

Introduction: the majority of patients with cardiovascular diseases in real medical practice are characterized by a combination of two or more diseases and conditions, that is, comorbidity. This places additional demands on the observation and treatment of this category of patients. Objective: to assess risk factors, the structure of comorbid conditions and the severity of psychoemotional disorders in patients with myocardial infarction with various forms of atrial fibrillation. Materials and methods: 138 patients (63 men, 75 women) who were hospitalized in the cardiology department of the City Clinical Hospital No. 7 GBUZ with a diagnosis of myocardial infarction with atrial fibrillation were examined. Depending on the form of atrial fibrillation, the patients were divided into 2 groups: the 1st consisted of 83 (60,1%) patients with a paroxysmal form, the 2nd group – 55 (39,9%) with a constant form. The examination was carried out in the first three days of hospitalization of patients. Results: in patients with myocardial infarction with a paroxysmal form of atrial fibrillation, the structure of risk factors is dominated by an average degree of nicotine addiction, dangerous alcohol consumption, high salt intake and excess body weight, and with a constant form of atrial fibrillation, a mostly weak and high degree of nicotine addiction, harmful alcohol consumption and obesity. Conclusion: in patients with myocardial infarction with a paroxysmal form of atrial fibrillation, the predominant risk factors are: dangerous alcohol consumption, high salt intake and overweight combined with depressive disorders in the form of subclinical and clinical depression, and with a constant form of atrial fibrillation, a high degree of nicotinic dependence and mild anxiety disorders: subclinically and clinically severe anxiety, which must be taken into account when carrying out preventive, rehabilitation measures and the solution of expert issues.

State of myocardium, stiffness of vascular wall and severity of emotional disorders in patients with myocardial infarction with atrial fibrillation

The widespread prevalence of myocardial infarction and the frequency of complications in the form of atrial fibrillation, makes it relevant to study its pathogenesis and effect on hemodynamics, significantly aggravating the patient’s condition, leading to a deterioration in hemodynamic parameters and the appearance of recurrent myocardial ischemia. At present, a large amount of data has been accumulated on the causes, electrophysiological mechanisms, and hemodynamic consequences of the development of atrial fibrillation during myocardial infarction. This circumstance necessitates both further study of the features of the development and course of atrial fibrillation, and the search for new approaches in organizing and optimizing the treatment of this complication. It is necessary to study in detail the structure of anxiety-depressive disorders, the state of the elastotonic properties of the vascular wall, endothelial function and heart remodeling in patients with myocardial infarction with various forms of atrial fibrillation.

Effect of acupuncture on emotional disorder in patients with chronic pain: a Meta-analysis

To systematically review the effect of acupuncture on emotional disorder in the patients with migraine and knee osteoarthritis and its effect time limit. The randomized controlled trials of acupuncture for migraine or knee osteoarthritis were retrieved from the databases, starting from the time of establishment through to December, 2018, i.e. the Cochrane Library, PubMed, EMbase, CNKI, SinoMed, VIP and Wanfang. The bias risk assessment tool of Cochrane Review Manual 5.1.0 was adopted to evaluate the quality of trials in methodology. RevMan 5.3 software was used for the Meta-analysis. A total of 12 articles were included, with 2450 cases. Regarding the immediate effect, the score of the emotional function subscale of migraine-specific quality-of-life questionnaire (MSQ) in the acupuncture group was higher than the control group (6.38[2.78,9.98], I 2=25%). In view of the emotional function subscale of the short-form of health survey (SF-36/SF-12), and the scores of the mental function and negative mode scale in Spain's index of quality of life (PQLC), there were no significant differences in the scores between the acupuncture group and the control group. In 3 months of treatment, the score of the emotional function subscale of MSQ in the acupuncture group was higher than the control group (9.66 [3.06,16.25], I 2=44%). The difference in the score of the mental health subscale of SF-36 and SF-12 was not significant between the acupuncture group and the control group. In 3 to 6 months of treatment, as well as in over 6 months of treatment, the score of every scale was not different statistically between the acupuncture group and the control group. Acupuncture effectively maintains the healthy emotion in the patients with migraine and the effect is sustainable for 3 months after treatment. But the improvement of acupuncture is not remarkable in emotional disorder induced by knee osteoarthritis.

Acupuncture for emotional disorders in patients with migraine: a systematic review protocol

IntroductionMigraine is the second-leading cause of years lived with disability worldwide. The high prevalence of migraine-related emotional disorders is often overlooked. Acupuncture is often used to treat both migraine and...