Regulation Of Emotional Responses Research Articles

Potential Anxiolytic and Antidepressant-Like Activities of SNC80, a Selective δ-Opioid Agonist, in Behavioral Models in Rodents

In the present study, we investigated the antidepressant- and anxiolytic-like effects of (+)-4-[(aR)-a-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC80), a non-peptidic selective δ-opioid receptor agonist, in various animal models in rodents. SNC80 significantly reduced the duration of immobility in the forced swimming test. Furthermore, in the elevated plus-maze test, SNC80 dose-dependently and significantly increased the time spent in the open arms of the plus-maze. These effects were completely antagonized by a selective δ-opioid-receptor antagonist, naltrindole. In the conditioned fear stress test, which examines psychological stress-induced motor suppression, desipramine did not produce any significant effect on the conditioned suppression of locomotor activity. However, SNC80 completely attenuated the conditioned suppression of locomotor activity in the conditioned fear stress test. In conclusion, our results suggest that δ-opioid receptors may play an important role in the regulation of emotional responses. Furthermore, it is possible that δ-opioid-receptor agonists might be novel and potent antidepressants that also have anxiolytic-like effects.

Facial expressivity to acute pain in cocaine-exposed toddlers

Expressive emotion regulation in response to stress following inoculation was examined in 30 18-month-olds. Fourteen were exposed to cocaine in utero and 16 were drug-free. Findings indicated that the cocaine-exposed group displayed fewer discrete negative expressions of distress and anger and more sadness in response to acute pain. These results suggest that cocaine exposure may exert an influence on the expression of emotion into the second year of life. © 1997 Michigan Association for Infant Mental Health