The H I, CO, and H-alpha data for M33 are analyzed to obtain high-mass star formation rates and efficiencies and to look for variations in these quantities within the inner disk of M33. Star formation rates and efficiencies are calculated using calibrated H-alpha data. The H-alpha emission in this region of the galaxy corresponds to high-mass and total star-formation rates of 0.007 and 0.04 solar mass/yr, respectively. These results agree reasonably well with the rates calculated from the 60 and 100-micron IRAS emission. The star formation rates obtained form FIR and H-alpha luminosities are compared with those obtained from optical photometry.