Background: Burnout refers to job dissatisfaction caused by work-related stress. The aim of this study was to explore the prevalence, risk factor, protective factors of burnout among emergency department healthcare providers in Al Jouf region hospitals. We aimed to investigate the psychological impact of burnout, how it weighs down on mental health and physical health, and ways to prevent it. Burnout syndrome is emotional exhaustion (EE), depersonalization (DP) and reduced personal accomplishment (PA) among individuals who work with people. Methodology: This study used a self-administered online questionnaire distributed through data collectors by sending the link to participants. A pilot study will be conduct on 10 subjects to estimate the time needed to fill the survey and test the logistics and its comprehensibility. A self-administered MBI-HSS was used to collect data on burnout in terms of emotional exhaustion, depersonalization and low personal accomplishment. Study period from March 2021– January 2022. Results: We found burnout to be multidimensional such that different variables were associated with one or more aspects of burnout. Majority of respondents felt emotionally drained from work a few times a week. Low personal accomplishment results are caused by factors such as age, marital status, smoking, psychological/ psychiatric disorders. The results showed that the highest mean and standard deviation for MBI-HSS subscale scores for risk burnout was found in emotional exhaustion. The majority of participants (71.28%) had high prevalence of high depersonalization. 84.43% of participants were not burnt out. Conclusion: Burnout is a syndrome of emotional exhaustion, depersonalization, and reduced personal accomplishment which arises in response to chronic stress in jobs where individuals work with people. Workers at the emergency department were more susceptible to burnout. Different factors are associated with burnout. Demographic factors of age, sex and marital status were significant in the study. Social and organizational solutions in preventing and alleviating this syndrome are recommended to address emotional exhaustion, depersonalization and low personal accomplishments.