Emergence Period Research Articles

Timing of Intraoperative Transitions of Care Among Anesthesiologists Is Not Associated With Postoperative Adverse Outcomes: Retrospective Cohort Study.

The majority of published research suggests that anesthesia handovers during major surgical procedures are associated with unintended harmful consequences. It is still unclear if the number or quality of the transition of care is the main driver of the adverse outcomes. There is even less data if the timing of the anesthesiologist handovers during the critical portion of the anesthetic continuum (induction or emergence versus surgical period) plays a role in patient outcomes. Therefore, we investigated if the anesthesiologist handovers during induction and emergence are associated with adverse patient outcomes. This retrospective investigation included noncardiac surgical procedures occurring between January 1, 2012 and December 31, 2019 that had exactly 1 attending anesthesiologist handover. We categorized transitions of care between attending anesthesiologists as being before incision, between incision and closing, and after closing. Our primary outcome was a composite of 6 categories of surgical complications and in-hospital mortality. We created logistic generalized estimating equation models to estimate the average relative effect odds ratio between each pair of the 3 transition timing groups across the components of the composite outcome. Inverse probability of treatment weights were used to mitigate confounding on a host of baseline variables. We used Bonferroni correction to adjust for multiple comparisons between the transition groups. In total, we studied 36,937 procedures with exactly 1 attending anesthesiologist handover. Of these records, 4370 had the transition during induction, 24,999 between incision and closure, and 7568 during emergence. No differences were found between the transition periods and the composite outcome. The estimated average relative effect odds ratio (98.3% confidence interval [CI]) across the components of the composite outcome was as follows: (1.0002 [0.81-1.24], P = .99) between the induction and surgical period; (1.10 [0.87-1.40], P = .32) between the induction and emergence periods; and (0.91 [0.79-1.04], P = .08) between the emergence and surgical periods. Timing of intraoperative handover among attending anesthesiologists during noncardiac surgery is not associated with adverse patient outcomes.

Long-read genome assembly of the Japanese parasitic wasp Copidosoma floridanum (Hymenoptera: Encyrtidae).

Copidosoma floridanum is a cosmopolitan species and an egg-larval parasitoid of the Plusiine moth. C. floridanum has a unique development mode called polyembryony, in which over two thousand genetically identical embryos are produced from a single egg. Some embryos develop into sterile soldier larvae precociously, and their emergence period and aggressive behavior differ between the US and Japanese C. floridanum strains. Genome sequencing expects to contribute to our understanding of the molecular bases underlying the progression of polyembryony. However, only the genome sequence of the US strain generated by the short-read assembly has been reported. In the present study, we determined the genome sequence of the Japanese strain using Pacific Biosciences high-fidelity reads and generating a highly contiguous assembly (552.7 Mb, N50: 17.9 Mb). Gene prediction and annotation identified 13,886 transcripts derived from 10,786 gene models. We searched the genomic differences between US and Japanese strains. Among gene models predicted in this study, 100 gene loci in the Japanese strain had extremely different gene structures from those in the US strain. This was accomplished through functional annotation (GGSEARCH) and long-read sequencing. Genomic differences between strains were also reflected in amino acid sequences of vasa that play a central role in caste determination in this species. The genome assemblies constructed in this study will facilitate the genomic comparisons between Japanese and US strains, leading to our understanding of detailed genomic regions responsible for the ecological and physiological characteristics of C. floridanum.

Determination of essential oil components of Ammi L. genus in Türkiye and their effects on some storage pests

Effects of essential oil components obtained by hydrodistillation of Ammi genus members (Ammi majus L., Ammi visnaga L. (Lam.)), which have important chemical and active components were investigated against two important storage pests; fig borer Cadra cautella (Walker) (Lepidoptera: Pyralidae) and flour moth Ephestia kuehniella Zeller (Lepidoptera: Pyralidae). A total of 23 and 14 components were detected in A. majus and A. visnaga, respectively, and the product yield was found to be 96.05%, 82.53%. Among them, the major components for A. majus are 2 heptadecanone, benzoic acid, 2 pentadecanone while for A. visnaga they are linalol, nonadecane, carvacrol. Essential oil of A. visnaga extended the adult emergence times in E. kuehniella and C. cautella while the increase in pupation time was found statistically significant only in E. kuehniella. A. visnaga essential oil reduced the adult life span in E. kuehniella at the highest dose while a decrease was detected in both doses applied in C. cautella. Adult weight and number of eggs decreased due to the application of A. visnaga in both insects. Also, alterations were observed in the adult emergence, pupation time, and pupal period. In E. kuehniella and C. cautella, adult life spans, weights and egg production of females showed statistically significant decreases depending on the application of A. majus essential oil. The findings obtained within the scope of the current study reveal that the essential oils of A. majus and A. visnaga species have the potential to be used in the control of storage pest insects.

Cancer screening and first-time visits to oncology services during and after COVID-19 pandemic in Uruguay.

e23016 Background: On March 13, 2020, Uruguay confirmed the first cases of COVID-19 and the same day the government declared a Public Health Emergency that was extended until April 4, 2022. The measures implemented to mitigate the transmission included, among others, postponing screening studies and in-person consultations. Added to these measures was the fear of going to health centers and the consequences of the economic crisis, with the increasing difficulties in traveling and facing the co-payments necessary to access health services. This study aims to evaluate the impact of the COVID-19 pandemic on cancer screening and first time- visits to oncology services during the public health emergency and following its lifting. Methods: We compare the number of PAP test, mammograms and fecal immunochemical test (FIT) reported by the same comprehensive health providers during 3 periods: pre-pandemic (2018-2019), public health emergency period (March 13, 2020- April 4, 2022) and post-public health emergency (April 5 2022-June 30,2023). Cancer screening data was obtained from the screening registry of the Honorary Commission to Fight Cancer (CHLCC) and first oncology visits from the Oncology Electronic Health Record (HCEO). Health providers that report PAP, mammograms, and FIT cover around 90%, 30%, and 40% of health system users, respectively, and those that use HCEO, 40%. Results: After two years of COVID-19 public health emergency, the number of reported PAP smears test, mammography and fecal occult blood test, decreased by 26%, 46% and 33% respectively (Table 1). The reduction was greater during the first months of the pandemic and during the peak of the first wave (April-June 2021: PAP -50%, mammography -58%, occult blood test: -70%). Likewise, the number of first-time visits to oncology services decreased by 37%, reaching a 56% decline during the first wave. As shown in Table 1, these declines continued after the health emergency was lifted. Conclusions: Our results show an important decline of cancer screening and first-time visits to oncology services during the pandemic in Uruguay. After emergency was lifted, reported PAP test showed a partial recovery but mammography, occult fecal blood test and first-time visits to oncology services remain well below pre-pandemic levels. [Table: see text]

코로나19 시기를 지나온 노년기 학습자의 자기주도적 학습경험에 관한 현상학적 탐구

This study explored the self-directed learning experiences of elderly learners who have continued lifelong learning for many years, including the COVID-19 period, using phenomenological qualitative research method. As a result of analyzing the learning experiences of 12 male and female learners aged 61-78 years, their self-direction was continuously exhibited throughout the entire period of learning. Participants in the study struggled to continue self-directed learning in their daily lives even during the crisis of self-directed learning due to COVID-19. As they passed this emergency period, the study participants became aware of the elements of the surrounding environment that facilitated self-directed learning, and explained various achievements in self-directed learning after recovery to daily life. The essence of self-direction explored in this study was reinforced in interaction with the surrounding environment rather than self-direction only by the individual's will. The surrounding environment can be explained by programs of lifelong education institutions, questions and discussions in face-to-face classes, relationships with instructors and fellow learners, and media in a digital technology environment, and these factors served as catalysts for self-directed learning and helped to strengthen the self-direction of learners in old age.

積石木槨墓 出現期의 樣相

The wooden chamber tomb with stone mound, representing the Silla period, is characterized by its high and large burial mounds. Therefore, the emergence of wooden chamber tombs with stone mounds signifies the construction of such high and large burial mounds. However, in the early stages, the typical features of wooden chamber tombs with stone mounds were not clearly observed, leading to various uncertainties. Currently, the earliest emergence of wooden chamber tombs with stone mounds is observed in Coffins No. 3 and 4 in Tomb No. 109 in Hwangnam-dong. However, unlike typical wooden chamber tombs with stone mounds, the wooden chambers in this tomb overlap vertically, and the placement of protective stones around the perimeter of the mound is also indistinct. This paper aims to elucidate the characteristics of the emergence period of wooden chamber tombs with stone mounds, starting from these uncertainties. Four tombs dating before and after the emergence of wooden chamber tombs with stone mounds were reviewed. As a result, it was observed that despite being tombs close to the highest social hierarchy of their time, they were later overlapped or destroyed by unrelated tombs from subsequent periods. This phenomenon was commonly observed in these tombs but not in wooden chamber tombs with stone mounds that appeared afterward. Additionally, these tombs lacked protective stones and exhibited relatively low burial mounds. Therefore, the reason for overlap or destruction by later tombs can be attributed to the low and flat burial mounds. In conclusion, contrary to previous assumptions, it can be inferred that immediately after the emergence of wooden chamber tombs with stone mounds, the burial mounds were low and flat. Subsequently, they evolved to have higher burial mounds along with protective stones. Recently, instances have been confirmed where burial mounds without protective stones were overlapped vertically beneath tombs with protective stones, indicating the characteristics of the emergence period of wooden chamber tombs with stone mounds.

EFFECTS OF THE COVID-19 PANDEMIC ON INGUINAL HERNIA SURGERY IN A SINGLE CENTER IN PORTUGAL: ANALYSIS OF EMERGENCY CASES AND TREATMENT PATTERNS

Abstract Background The COVID-19 pandemic triggered substantial shifts in healthcare priorities, redirecting resources to address unprecedented emergency needs. Concerns about how COVID-19 might affect surgical outcomes prompted our investigation, given the complex interplay of factors across diverse healthcare settings. Our study sought to understand the impact of emergency declarations on the treatment of inguinal hernias, examining changes in elective versus emergent surgeries, as well as variations in surgical techniques and care settings. Method Analyzing five years of data (2019–2023) from a single institution in Almada, Portugal, we collected demographic and procedural information, comparing patients treated during the pandemic's confinement period (March 18, 2020, to April 30, 2021) with those treated before and after this period. Results Of the 1764 identified patients, 1004 underwent surgery elsewhere, leaving 760 for analysis. While only 2.9% required emergency surgery, some elective cases were labeled as "delayed urgencies" or "high priority," suggesting potential influences of emergencies on elective treatment decisions. Before the pandemic, 4.3% underwent emergency surgery, dropping to 1.1% during the emergency period, and rising to 3.1% afterward, though these changes lacked statistical significance. Laparoscopic surgeries increased gradually, while ambulatory procedures decreased, likely due to local restrictions rather than COVID-19. Conclusion Our findings echo previous research indicating a decrease in emergency surgeries contrary to expectations. However, data biases may exist, highlighted by an uptick in patients receiving surgery within 15 days, possibly reflecting shifts in healthcare accessibility rather than direct COVID-19 effects.

Impact of different host plants on biology and morphometrics of various developmental stages of Papilio demoleus (Linn.)

The comparative studies under laboratory conditions have been carried out to investigate the influence of different alternative host plants viz., bael [Aegle marmelos (L.)], curry leaves [Murraya koenigii (L.) Spreng.], ber (Zizyphus mauritiana Lam.) and lemon [Citrus limon (L.) Burm.f.] on biology and morphometrics of Lemon butterfly, Papilio demoleus (Linn.). The lemon is the most preferred host of P. demoleus used as a controlled experimental host plant. The variations in periods of larval, pupal and rate of emergence into adult have been recorded and found that the lemon was the most preferred host plant on which all the larval stages survived smoothly. The caterpillars when reared on alternative hosts showed an increase in average larval period. The average survival percent of larvae were reported highest on bael leaves, followed by curry leaves and ber leaves. Similar patterns of results were also recorded on the pupal period and rate of emergence with alternative hosts. The morphometric variations in weight, size and colour of caterpillars, pupae and adults were also measured and found in decreasing order of host preferences as lemon[greater than]bael[greater than]curry[greater than]ber.

A multi-period optimal distribution model of emergency resources for responding to COVID-19 under uncertain conditions

Ideally, optimal emergency resource allocation would have been vital for effective relief work during the COVID-19 outbreak. However, the suddenness of the epidemic and uncertainty of its spread added some difficulties to distributing emergency resources. First, this study introduces triangular fuzzy numbers to describe the uncertainty of supply and demand of emergency resources, and interval numbers to describe the time required for resource transportation under disaster conditions. To minimize the total delivery time and difference in the total satisfaction rate, this study constructs an optimal model for emergency resource distribution under uncertain conditions that considers both efficiency and equity. Subsequently, an improved genetic algorithm (IMGA) is proposed to obtain the optimal decision scheme. Finally, a case study on emergency resource distribution during the COVID-19 pandemic is conducted for model verification. The results demonstrate that the proposed model can improve the efficiency and effect of emergency resource distribution. The model allocates some emergency resources to each demand site during each emergency period, which can help avoid large losses caused by extreme shortages of resources at a certain demand point. The emergency resource allocation scheme considers the transportation time and degree of impact, which is beneficial for enhancing the flexibility of decision-making and practical applicability of distribution operations. A comparative analysis of the algorithms shows that the proposed IMGA is an effective method for managing emergency resource distribution optimization problems because it has higher solving efficiency, better convergence, and stronger stability. These findings can provide decision support for the optimal distribution of large-scale, multiperiod emergency resources during the COVID-19 pandemic.

The Rise of Catholic Thought on Social Communication in the Pontificate of Paul VI

Abstract In a period of mass media emergence and renewal of Catholicism after Vatican II, the church initiated into a profound approach to its Social Doctrine on the media. With a theology of communication as a cornerstone, numerous ecclesial documents published during the Papacy of Paul VI explored the implications of the media for society and the internal life of the church. This study aims to analyse the contents on the media addressed in official documents of the Catholic Church during the Pontificate of Paul VI. The conclusions of the research show to what extent communication is a significant issue for public theology and delve into the meaning of the right to information and public opinion, the place of the media in education, the training of communicators and recipients, the importance of the media for the church, and the involvement of Catholics in the media.

Impact of COVID-19 on women living with HIV who are survivors of intimate partner violence

BackgroundWomen living with HIV (WLWH) experience higher rates of intimate partner violence (IPV) compared to women without HIV, but there has been minimal research to date on the impact of the COVID-19 pandemic on the lived experiences of WLWH who are IPV survivors.MethodsThis is a secondary analysis of COVID-19 impact using baseline data from an ongoing, prospective, micro-longitudinal cohort study of HIV care engagement among WLWH who have experienced lifetime IPV. We measured the impact of COVID-19 along key domains (i.e., physical health, day-to-day life, sexual/relationship behavior, substance use, HIV care, mental health, financial status, and having conflict with partners). Using independent t-tests or Fisher’s exact tests, and Pearson’s chi-squared tests, we compared women with and without ongoing IPV across sociodemographic characteristics, psychiatric disorders, substance use, and COVID-19 impact domains. We then built separate multivariate linear regression models for each of the different COVID-19 impact domains; ongoing IPV exposure was the primary explanatory variable of interest.ResultsEnrolled participants (n = 84) comprised a group of women (mean age 53.6y; SD = 9.9) who were living with HIV for a mean 23.3 years (SD = 10), all of whom had experienced lifetime IPV. Among 49 women who were currently partnered, 79.6% (n = 39) reported ongoing IPV. There were no statistically significant differences between those experiencing ongoing IPV and those who were not (or not partnered) in terms of demographic characteristics, substance use, or mental health. In multivariate models, ongoing IPV exposure was not associated with any COVID-19 impact domain. Anxiety and depression, however, were associated with COVID-19-related physical health, HIV care, and relationship conflict. Hispanic ethnicity was significantly associated with COVID-19-related physical health. More severe cocaine and opioid use were also significantly associated with COVID-19-related impact on day-to-day life.ConclusionsAmong this sample of WLWH who are all lifetime IPV-survivors, nearly half had ongoing IPV exposure. The COVID-19 public health emergency period affected WLWH in varied ways, but impacts were most profound for women experiencing concurrent mental health and substance use problems. Findings have important implications for future interventions to improve women’s health and social outcomes.

The Free-Running Circasemilunar Period Is Determined by Counting Circadian Clock Cycles in the Marine Midge Clunio Marinus.

Semilunar rhythms are found in numerous marine organisms, but the molecular mechanism and functional principles of endogenous circasemilunar clocks remain elusive. Here, we explore the connection between the free-running circasemilunar clock and the circadian clock in the marine midge Clunio marinus with three different chronobiological assays. First, we found that the free-running circasemilunar period of the adult emergence rhythm in C. marinus changes linearly with diel T-cycle length, supporting a day-counting mechanism. Second, under LD 6:6, periods of circasemilunar and circadian emergence were comparable to those under LD 12:12, indicating that the circasemilunar counter in C. marinus relies on endogenous circadian oscillations rather than external T-cycles. Finally, when desynchronizing the circadian clock with constant light, the free-running circasemilunar emergence rhythm disappeared as well, suggesting that it requires a synchronized circadian clock. These results oppose the long-held view that C. marinus' free-running circasemilunar clock operates independently of the circadian clock. In a broader evolutionary context, our results strengthen the idea that the circasemilunar clocks of dipterous insects are based on different functional principles compared to the circasemilunar or circalunar clocks of marine annelids and algae. These divergent clock principles may indicate multiple evolutionary origins of circasemilunar and circalunar clocks.

Resilience assessment and optimization method of city road network in the post-earthquake emergency period

Resilience assessment and optimization method of city road network in the post-earthquake emergency period

The use of healthcare services and disabling chronic pain: results from the cross-sectional population-based Andalusian Health Survey.

Several factors seem to be related to the use of healthcare services, and chronic pain (CP) is among these characteristics. The objective is to describe the number of visits to a doctor's surgery or emergency rooms, and the periods of hospitalization; to identify characteristics associated with frequent healthcare use, including disabling chronic pain (DCP) and non-disabling chronic pain (n-DCP). Representative population-based cross-sectional study of 6569 people older than 16 years from southern Spain was collected. The frequency of visits to a doctor's surgery or emergency rooms and periods of hospitalization were defined as at or above the 90th percentile. Binary logistic regression analyses were conducted separately on women and men to identify characteristics associated with being frequent visitors. People with DCP are more frequent visitors to a doctor's surgery and emergency rooms and endure longer periods of hospitalization compared to people with n-DCP and without pain. In logistic regression models, people with DCP are twice as likely to over-visit a doctor's surgery; to endure longer periods of hospitalization and more visits to an emergency room service. No relationship was found in n-DCP. Disability seems to modulate a greater use of health services among the population with CP, doubling it when compared to n-DCP and n-CP, both in women and men. Understanding the role of disability in the use of healthcare services for individuals with CP allows for the identification of needs and strategies to optimize resources.

Digital Drawing Innovation of Ornaments through Ibis Paint Application

The learning process of ornaments drawing in the Junior High School of Boyolali during the emergency period of the spread of Covid-19 was conducted online. This study follows Bord and Gall’s research and development (R&D) method (1983). Data collection methods were carried out by participatory observation, in-depth interviews, closed questionnaires, and documentation, and data analysis was carried out with a qualitative and quantitative approach. The purpose of this study is to provide a foundation for students to appreciate art and use their imaginations as a trigger for their creativity. That is achievable, though, if educators provide learning in a captivating manner. One way to achieve this aim is by innovating learning media based on Android smartphones with tools like ornaments digital drawing using Ibis Paint application, which can be used by students online and offline to make them understand the subject easily. Learning media innovations can be conducted by exploring video tutorials, text, and images that are presented on a website for online and offline learning processes. The results of the test showed that the data of the material expert test are 99%, the media expert test are 98%, and the website expert test are 98%. These results conclude that innovation in learning media with material ornaments digital drawing is appropriate, relevant, and needed by students for their art appreciation and imagination expression in online and offline learning processes. The role of media in achieving learning objectives has been proven effective because students showed active behavior. Innovation in learning media simplifies the understanding of concepts through visualizations, graphics, animations, and other multimedia presentations. This helps students have a better comprehension of complex concepts. Keywords: learning media, digital drawing, ornaments

Intensive Cognitive Behavioral Therapy for Adolescents with Anorexia Nervosa Outcomes before, during and after the COVID-19 Crisis.

Studies comparing treatment outcomes in patients with eating disorders before and during the coronavirus (COVID-19) pandemic have yielded conflicting results. Furthermore, no study has yet evaluated treatment outcomes in adolescent patients with anorexia nervosa before, during and after the crisis. Hence, this study investigated the outcomes of an intensive Cognitive Behavioral Therapy-Enhanced (CBT-E) program on adolescents with anorexia nervosa consecutively treated before (n = 64), during (n = 37) and after (n = 31) the period of emergency spanning 8 March 2020 to 31 March 2022. Results show consistent and similar improvements in eating disorder psychopathology, general psychopathology and body mass index-for-age percentiles across all three periods, with approximately 60% of patients maintaining a full response at the 20-week follow-up, suggesting that treatment efficacy remained robust. Overall, the study underscores the effectiveness of intensive CBT-E as a viable treatment option for adolescents with anorexia nervosa, even during and after unprecedented challenges such as those posed by the COVID-19 pandemic.

Polyparadigmatic uncertainty of international economic relations in the global security system

Polyparadigmatic uncertainty of international economic relations in the global security system

Greek Primary School Teachers’ Narratives about their Role Negotiation during the Covid-19 Pandemic

No one can dispute the fact that the teaching profession seemed to be tested during the coronavirus pandemic. Teachers were called upon to perform a difficult and multifaced role, without help and support from the state. The issues that teachers had to respond to and solve are related to their autonomy, their digital literacy competences and their relationships/cooperation with students. The new working conditions terrified teachers, who had to manage their digital classroom through a violent readjustment. Under these circumstances, Greek primary school teachers’ narratives offer us their phenomenological perspective on how they coped with their teaching duties during this period of health and educational emergency. An initial attempt is made to empathetically approach the ‘world’ of four teachers, while the subsequent interpretive and critical analysis serves as a means to illuminate ‘hidden’ beliefs of their professional role, the reshaping of their identity, and their adaptation to the online teaching context. Through their narratives, the teachers reflect on the issue of the lack of support from the state. They also note that they found it difficult to manage their e-classes in such a short time. Finally, there is a need for more effective preparation of teachers in times of uncertainty and crisis.

Phenological patterns from two sympatric subspecies of the palm Geonoma cuneata (H. Wendl. ex Spruce) and their gall inductor Contarinia geonomae (Gagné)

Geonoma cuneata is a variable species with eight subspecies and one of two palms worldwide with a gall record. In this species, staggered flowering has been suggested as a possible mechanism to explain its reproductive isolation from sympatric subspecies. In this study, we examined the phenology of two G. cunea­ta subspecies and their gall inductor, Contarinia geonomae, in the Caribbean lowlands of Costa Rica. For 207 consecutive weeks, we monitored the phenology of 79 G. cuneata individuals and recorded the outcomes of 434 inflorescences in terms of abortions, fruit, and gall success. We analyzed phenological patterns, checked for seasonality and synchrony, and evaluated the effects of precipitation and temperature on each phenophase. The reproductive outcomes of the two subspecies were compared in terms of abortions of the inflorescences and the development of fruits or galls in the infructescences. Both subspecies were mainly seasonal and showed a clear overlap in all phenophases during the four years of study. However, seasonality and synchrony were very well marked in G. cuneata subsp. cuneata whereas G. cuneata subsp. procumbens was characterized by lower synchrony and higher abortion rates. Emergent inflorescences were influenced by average temperature, while flowering was influenced by monthly rainfall and average temperature. More­over, the peak flowering occurred just after the end of the dry season, whereas ripe fruits peaked at the end of the rainy period. Ripe fruits showed higher levels of synchrony and were the only phenophase in which the mean date did not differ among subspecies. This was partly explained by the higher number of abortions and lower fruiting success of individuals flowering outside the peak period. Instead, such indi­viduals are more likely to have infructescences with galls and higher loads. Flowering convergence did not support phenology as a mechanism of reproductive isolation. However, an extended combination of time from flowering to fruiting in both subspecies benefits the gall inductor by providing an extended period of oviposition and adult emergence.

Activity of the Sodium Leak Channel Maintains the Excitability of Paraventricular Thalamus Glutamatergic Neurons to Resist Anesthetic Effects of Sevoflurane in Mice.

Stimulation of the paraventricular thalamus has been found to enhance anesthesia recovery; however, the underlying molecular mechanism by which general anesthetics modulate paraventricular thalamus is unclear. This study aimed to test the hypothesis that the sodium leak channel (NALCN) maintains neuronal activity in the paraventricular thalamus to resist anesthetic effects of sevoflurane in mice. Chemogenetic and optogenetic manipulations, in vivo multiple-channel recordings, and electroencephalogram recordings were used to investigate the role of paraventricular thalamus neuronal activity in sevoflurane anesthesia. Virus-mediated knockdown and/or overexpression was applied to determine how NALCN influenced excitability of paraventricular thalamus glutamatergic neurons under sevoflurane. Viral tracers and local field potentials were used to explore the downstream pathway. Single neuronal spikes in the paraventricular thalamus were suppressed by sevoflurane anesthesia and recovered during emergence. Optogenetic activation of paraventricular thalamus glutamatergic neurons shortened the emergence period from sevoflurane anesthesia, while chemogenetic inhibition had the opposite effect. Knockdown of the NALCN in the paraventricular thalamus delayed the emergence from sevoflurane anesthesia (recovery time: from 24 ± 14 to 64 ± 19 s, P < 0.001; concentration for recovery of the righting reflex: from 1.13% ± 0.10% to 0.97% ± 0.13%, P < 0.01). As expected, the overexpression of the NALCN in the paraventricular thalamus produced the opposite effects. At the circuit level, knockdown of the NALCN in the paraventricular thalamus decreased the neuronal activity of the nucleus accumbens, as indicated by the local field potential and decreased single neuronal spikes in the nucleus accumbens. Additionally, the effects of NALCN knockdown in the paraventricular thalamus on sevoflurane actions were reversed by optical stimulation of the nucleus accumbens. Activity of the NALCN maintains the excitability of paraventricular thalamus glutamatergic neurons to resist the anesthetic effects of sevoflurane in mice.