Elevated Serum Glutamic Oxaloacetic Transaminase Research Articles

An evaluation of serum transaminase in the jaundice states.

13 that the serum glutamic oxalacetic transaminase (SGOT) became elevated after myocardial infarction, a large number of reports have been published dealing with abnormal elevation of this enzyme in diseases of the heart and other organ systems. Generally, elevated SGOT has been observed in 6 chief groups of ill­ nesses. These include injury to skeletal muscle, hepatobiliary disease, extensive damage to the brain, hemolytic anemia, certain chemical and drug intoxications, and, in some instances, pulmonary infarction. 1-8 • 10-12, 14-19, 21 , 22, 24, 26-34 Apart from the characteristically transient elevation of SGOT after myocardial infarc­ tion, there have been no established unified criteria for the evaluation of abnormal levels of SGOT in these other pathologic condi­ tions. This paper deals with a study of the lev el of serum transaminase in patients with jaundice of varying etiology. These cases, for the most part, were followed by serial determinations of SGOT and, to a limited extent, by analyses of serum glutamic pyruvic transaminase (SGPT). METHODS AND MATERIALS

Serum enzymes in disease. I. Lactic dehydrogenase and glutamic oxalacetic transaminase in carcinoma.

Lactic dehydrogenase (LD), an enzyme which can catalyze the conversion of lactate to pyruvate, has been demonstrated in the serum of animals^1-3and humans.^4-6Hill and Levi⁴studied 51 patients with neoplastic disease, only 2 of whom failed to exhibit elevated serum levels of this enzyme. Bierman and his associates⁵found elevated levels in 121 out of 132 patients with carcinoma. In an earlier report⁷from this laboratory, elevated LD levels were noted in half of 30 patients with carcinoma. Serum glutamic oxalacetic transaminase (GOT), an enzyme which catalyzes the reversible transfer of an amino group from aspartate to α-ketoglutarate has also been studied in neoplastic disease. Wróblewski and LaDue⁸reported elevated serum GOT levels in 23 of 25 patients with proved carcinomatosis involvement of the liver. Subsequently, these workers reported elevations of GOT in 75 out of 100 patients with primary hepatoma or

On the Mechanism of the Elevation of Serum Glutamic-Oxalacetic Transaminase (SGO-T) in Obstructive Jaundice

On the Mechanism of the Elevation of Serum Glutamic-Oxalacetic Transaminase (SGO-T) in Obstructive Jaundice

On the mechanism of the elevation of serum glutamic-oxalacetic transaminase (SGO-T) in obstructive jaundice.

On the mechanism of the elevation of serum glutamic-oxalacetic transaminase (SGO-T) in obstructive jaundice.

The serum transaminase test in various diseases. Its diagnostic value in liver disease

1. 1. The results of serum glutamic-oxalacetic transaminase (SGO-T) tests in 111 patients with a wide variety of disease states is reported. 2. 2. No elevations of SGO-T were found in patients with mild benign idiopathic pericarditis, uncomplicated congestive heart failure, various forms of congenital and acquired heart disease, 2 cases of pulmonary infarction, chronic pancreatitis, quiescent nonlctsric cirrhosis of the liver, congenital hemolytic jaundice, various forms of cancer, cerebral vascular accidents, pneumonia, subphrenic abscess, chronic nephritis, dissecting aneurysm, diabetes, dermatomyositis, 50 per cent of postoperative patients, and 4 out of 5 newborn infants. 3. 3. Slight elevations of SGO-T were found in rheumatic pericarditis, pulmonary infarctions with and without congestive heart failure, quiescent nonicteric cirrhosis of the liver, chronic lymphatic leukemia, one cerebral vascular accident, scleroderma, shock, diverticulitis of the colon, probable renal infarction, some postoperative patients, and 1 newborn infant. 4. 4. Marked elevationsof SGO-T were found in severe idiopathic pericarditis, preterminal shock and cyanosis, acute pancreatitis, viral hepatitis, obstructive jaundice, cirrhosis of the liver with jaundice, metastatic cancer of the liver, muscular dystrophy, paroxysmal myoglobinuria, infarcts of kidney and brain, one postoperative patient. 5. 5. In liver disease, biliary obstruction produces levels of SGO-T ranging from 100 to 200 units, while active cell destruction as seen in hepatitis and active cirrhosis produces levels of 300 to 2,000 units.

Serum glutamic-oxalacetic transaminase in coronary artery disease; a review of 201 cases.

The results of serial glutamic-oxalacetic transaminase (GOT) assays in 201 cases in which coronary artery disease was suspected are correlated with the clinical, laboratory, and electrocardiographic changes. In 95 per cent of the cases diagnosed as myocardial infarction on the basis of clinical and electrocardiographic evidence there was an elevation of serum GOT. On the other hand, in 12 per cent of the cases in which clinical and electrocardiographic findings were negative or equivocal with regard to myocardial infarction, there was an elevated serum GOT. In 18 cases that were autopsied the correlation between acute myocardial necrosis and serum GOT elevation was 100 per cent.

Effect of aspirin administration on serum glutamic oxaloacetic and glutamic pyruvic transaminases in children.

SummaryThe effect of aspirin and of sodium salicylate administration on the serum glutamic oxaloacetic transaminase activity in 14 children and its effect on both the serum glutamic oxaloacetic transaminase and the serum glutamic pyruvic transaminase in an additional 9 children has been studied. Elevations to abnormal levels were observed in more than 50% of the cases. The importance of this finding in relation to the interpretation of the serum glutamic oxaloacetic transaminase elevations in rheumatic fever is pointed out and some possible underlying reasons for this phenomenon are mentioned.