Elevated Phosphate Levels Research Articles

Studies on the involvement of testicular hormone in the regulation of pyridoxal phosphate formation by the kidney tissue.

ABSTRACT. The effects of castration and administration of testicular hormone (TH) on pyridoxal phosphate formation in vivo by kidney tissue have been studied in male albino rats. Castration lowered the pyridoxal phosphate concentration of kidney. Administration of testosterone to castrated rats restored the pyridoxal phosphate level of kidney, while normal rats showed increased kidney pyridoxal phosphate level. The kidney of castrated rats, unlike liver, failed to show elevated pyridoxal phosphate level in response to exogenous administration of pyridoxine. Decreased pyridoxal phosphate concentration in kidney following castration was associated with diminished kidney pyridoxine phosphate oxidase activity. Castrated rats upon receiving testosterone showed normal pyridoxine phosphate oxidase activity in kidney, while the same treatment enhanced the pyridoxine phosphate oxidase activity in the kidney of normal rats. Neither castration nor administration of testosterone had an effect on pyridoxal kinase acti...

On the deposition and utilization of inorganic pyrophosphate in Tetrahymena pyriformis

1. 1. Tetrahymena pyriformis deposit calcium magnesium pyrophosphate in spherical granules which appear to be surrounded by membranes. 2. 2. The deposition of granules occurs in the stationary phase and is greatly augmented by elevated levels of phosphate, Ca 2+ and Mg 2+ in the medium; the presence of two divalent cations is essential for this process. The granules disappear rapidly during phosphate deprivation. 3. 3. Associated with the granules is a pyrophosphatase activity which hydrolyses specifically the pyrophosphate of the granules. 4. 4. Phosphotransferase activity involving pyrophosphate could not be demonstrated in Tetrahymena and we conclude that the function of these deposits is that of phosphate storage.

Composition of Seams in Cheddar Cheese

The material comprising the obvious light-colored seams in some Cheddar cheeses now commercially available was analyzed in situ and after isolation. From the data obtained, it was concluded that the seam material contained primarily whey proteins, slightly elevated levels of chloride, calcium and phosphate. Some fat was also present but was not studied. The seam area is characterized by a pH approximately one unit higher than the bulk cheese. The ratio of calcium to phosphate indicates that it may be present in the form of calcium orthophosphate.

Studies of Rickettsial Toxins

Studies of Rickettsial Toxins