The involved object of systematic innovation and management is neither a single goal nor a single meth-od. Firstly, the research object is a systematic and organic whole composed of multiple node elements with a certain degree of correlation. Secondly, the research method is multi-dimensional, comprehensive, all round and highly efficient. Innovation should break through the existing thinking framework, change the existing structure, add new components, give new energy and produce new functions. The 5W1H is a questioning approach and a problem-solving method that answers all the basic elements within a problem which are what, who, when, where, why, and how. It aims to view ideas from various perspectives and gain an in-depth understanding of a specific situation. On the basis of 5W1H analysis method, this paper puts forward the 6WHI systematic innovation management method, which increases the query words weather and if of the innovation expansion solution, increases the number of questions from 6 to 8, and expands innovative forward-looking and innovative solutions diversity, with smoother pronunciation, more exciting storm. Furthermore, a systematic innovation method based on 6WHI and total factor analysis is established, and a more general and normative model WIME method is presented. This method can be utilized as a continuous process-improvement technique in an organization. Taking the 17 letters of “if question patents” as the prefix, they are just 17 common key elements in system management and innovation. For each element mentioned above, 8 questions and answers of 6WHI are given to realize systematic management and innovation. The above two types of work are arranged according to the matrix format, and then the weighted evaluation method is introduced to evaluate the above management and innovation work, so as to give a general and standardized systematic management and innovation (WIME) method.