Before the discovery of the nuclear chain reaction, the cyclotron was the only important source of radioactive isotopes for medical purposes. The development of the nuclear reactor made large scale isotope production possible and a wide range of radioactive isotopes is now readily available at a reasonably low cost. In consequence the demand for cyclotron-produced isotopes has decreased. However, there is now an increasing requirement for isotopes which are not available from the reactor for one reason or the other but which can be produced in a cyclotron. The true magnitude of this requirement is as yet unknown and can only be properly assessed by making such isotopes more freely available. Isotopes are produced in the reactor by neutron capture, by fission, or when the thresholds are suitable, by (n, p) or (n, α) reactions. It can be seen from Fig. 1 that (n, γ), (n, p) or (n, α) reactions tend to produce nuclides with a surplus of neutrons. Such isotopes decay towards the stability line by emission of negative electrons. Most fission products and their daughters also decay in this manner. It is in consequence rarely possible to obtain from the nuclear reactor an isotope which is neutron-deficient and which therefore decays either by emission of positive electrons (positrons) or by orbital electron capture followed by emission of characteristic X rays. Such isotopes can only be prepared in a cyclotron (Moeken, 1957) or a high-energy (20 to 30 MeV) linear accelerator (MacGregor, 1958), but often have desirable properties.