The science literacy skills of Indonesian students are still low based on the results of PISA 2022. Chemical equilibrium material is very important, and understanding chemical equilibrium is a prerequisite for understanding subsequent materials. One of the efforts to improve understanding of chemical equilibrium material is applying a student-centred learning model, the PBL model. PBL can also improve students' science literacy skills. Thus, research was conducted to develop PBL-oriented interactive electronic student activity sheets on chemical equilibrium material to improve students' science literacy skills. This research aims to describe the effectiveness of interactive E-LAPD as a learning media for improving students' science literacy skills. Research and development (Research and Development) is the type of research used. The research design used in this research is the 4-D model development research design according to Thiagarajan's 4-D model, which consists of the define, design, develop, and disseminate stages. The instrument used in this research is a pretest and posttest sheet of science literacy skills to measure students' science literacy skills. This research used a limited trial with a one-group pretest-posttest research design. The limited trial was conducted at SMAN 1 Kedamean with 36 class XI MIPA 3 students. The effectiveness results analyzed using the paired sample t-test obtained a p-value of 0.000, which indicates that the posttest value after learning using interactive E-LAPD is greater than the pretest value before learning using interactive E-LAPD. Thus, PBL-oriented Interactive E-LAPD can be said to improve students' science literacy skills.