Spinel magnesium ferrite nanoparticles play an important role in a variety of disciplines, particularly in environmental applications as magnetically separable photocatalysts. MgFe2-1.67xVxO4 with x = 0.0, 0.05, 0.10, and 0.20 were synthesized using the combustion method. X-ray diffraction (XRD) indicated that only the cubic spinel ferrite phase with the Fd3m space group was formed in all doped Mg-ferrite. The cell parameter increased at (x = 0.05) and thereafter dropped with increasing vanadium ion concentration. The saturation magnetization (Ms) increased from 26.181 to 28.953 with x = 0.05, then decreased with further doping. Additionally, the band gap energy (Eg) decreased with increasing v-doping; Eg for MgFe2O4 was 1.79 eV and decreased to 1.71 eV at x = 0.20. All the V-doped MgFe2O4 shows an increase in the efficiency of methyl orange photodegradation relative to undoped MgFe2O4. The boosting in photocatalytic activity of V-doped MgFe2O4 due to electron-hole separation, caused by oxygen vacancies. V-doping changes the point of zero charge of ferrite and increase the MO adsorption, consequently, enhances the photocatalytic degradation. V-doped MgFe2O4 has proved to be an effective magnetically separable and easily reusable photocatalyst withstand seven cycles of recyclability using MgFe2-1.67xVxO4 with x = 0.10, and only 4 % loss of its photocatalytic performance.