The role of a 2D electron-hole lattice system in the modulated structure of Bi2-xPbxSr2CaCu2O8+δ (Pb-doped Bi-2212) is discussed. The 2D electron-hole lattice system is constructed by neutralizing local polarization charges on the crystal surface or between two adjacent layers. Assuming that the Pb type of modulation is obtained by reversing two neighboring polarizations in the Bi type of modulation in pairs, we explain the following experimental findings: (1) the ratio of the modulation period of the Pb type structure, k2, to that of the Bi type structure, k1, gives discrete values, such as k2/k1=3/2, 5/3, and 2; (2) as x increases, k2 tends to increase and approximately follows the relationship k2-k1\\proptx; (3) when the sample is irradiated with an intense electron beam, the modulation of the Pb type transforms into that of the Bi type. The physical meaning of the above assumption is discussed.