A closed-loop option for reusing, remanufacturing, and recycling waste products in the olive industry creates a high added value for this business network. This fact motivates the implementation of closed-loop supply chains for adopting an efficient and sustainable strategy in the olive industry in Iran. As one of the developing countries, Iran must redesign their supply chain networks to meet the standards of sustainable development goals. In this regard, the triple bottom line approach focuses on a sustainable design considering all economic, environmental, and social factors in supply chain networks. The main novelty of this paper is to merge the sustainable Closed-Loop Supply Chain Network (CLSCN) design and the olive industry. Hence, a multi-objective optimization framework is proposed to make location, allocation, and inventory decisions for the considered problem. Based on the triple bottom line approach, the objectives of the optimization model are to minimize the total cost and carbon dioxide (CO2)emissions and maximize job opportunities. In small instances, the model is solved by an epsilon-constraint method. To address the high complexity of large-scale networks, this study innovates new hybrid optimization algorithms. In this regard, a hybrid of Virus Colony Search Algorithm (VCS) and Simulated Annealing (SA) and a combination of Electromagnetism-like Algorithm (EMA) and Genetic Algorithm (GA) are proposed for the first time. To confirm their efficiency, an extensive comparison with individual algorithms is carried out by different multi-objective optimization metrics. Finally, some sensitivity analyses are performed to discuss some practical insights for the supply chain managers working in the olive industry in Iran.