Electrohysterogram Research Articles

Electrical Inhibition (EI) of Preterm Uterine Contractions: Electrical and Mechanical Activity

Background: Uterine smooth muscles produce bundles of electrical activity or electromyogram (EMG) preceding and controlling uterine mechanical contractions. Uterine preterm and term contractions are a function of contraction frequency and force. Uterine tocodynamometry (TOCO) monitors mechanical contraction frequency objectively by peak-to-peak (P-P) interval but force only subjectively by amplitude. Computer algorithms convert uterine EMG into an electrohysterogram (EHG) a more objective measure of contraction force (fig. 1A and 1B) than TOCO. Analysis of the EMG power spectral density (PSD) isolates the electrical bundle peak frequency (fp). Uterine fp indicates maximum contraction activity and is reduced with pharmaceutical tocolytics. An EI current delivered by an electrical pacemaker i.e. an electroceutical tocolytic may be …

Application of decision tree in determining the importance of surface electrohysterography signal characteristics for recognizing uterine contractions

The aims of this study were to apply decision tree to classify uterine activities (contractions and non-contractions) using the waveform characteristics derived from different channels of electrohysterogram (EHG) signals and then rank the importance of these characteristics. Both the tocodynamometer (TOCO) and 8-channel EHG signals were simultaneously recorded from 34 healthy pregnant women within 24h before delivery. After preprocessing of EHG signals, EHG segments corresponding to the uterine contractions and non-contractions were manually extracted from both original and normalized EHG signals according to the TOCO signals and the human marks. 24 waveform characteristics of the EHG segments were derived separately from each channel to train the decision tree and classify the uterine activities. The results showed the Power and sample entropy (SamEn) extracted from the un-normalized EHG segments played the most important roles in recognizing uterine activities. In addition, the EHG signal characteristics from channel 1 produced better classification results (AUC=0.75, Sensitivity=0.84, Specificity=0.78, Accuracy=0.81) than the others. In conclusion, decision tree could be used to classify the uterine activities, and the Power and SamEn of un-normalized EHG segments were the most important characteristics in uterine contraction classification.

Estimation of 8-Electrode Configuration for Recognition of Uterine Contraction with Electrohysterogram.

As the representative of electrical activity from uterine muscle, electrohysterogram (EHG) is recorded non-invasively by multiple electrodes positioned on the abdominal surface. The purpose of our paper is to estimate different electrode configurations for recognizing uterine contractions (UCs) with EHG signals. 8-electrode configuration was taken as an example to show our novel method with convolutional neural network (CNN) classification and score. The open accessed Icelandic 16-electrode EHG database was adopted in our study. With 8-electrode configuration, EHG signals corresponding to UCs and non-UCs were segmented and saved as image patches. The CNN was established and trained by thousands of EHG segments. The performance of CNN was evaluated by the area under curve (AUC) and accuracy of recognizing UCs and non-UCs. Seven different 8-electrode configurations were scored and ranked. It was found the 8-electrode configuration with 4 on the uterine fundus, 2 on the body and 2 on the cervix achieved the AUC of 0.766 and the highest score of 2.197. Among the configurations we have tried, it is concluded that the 8 electrodes in 4-2-2 configuration placed along the uterus as an upside-down pear could provide the most important information for recognition of UC based on our experiments.

Development of Electrohysterogram Recording System for Monitoring Uterine Contraction.

Uterine contraction (UC) is an important clinical indictor for monitoring uterine activity. The purpose of this study is to develop a portable electrohysterogram (EHG) recording system (called PregCare) for monitoring UCs with EHG signals. The PregCare consisted of sensors, a signal acquisition device, and a computer with application software. Eight-channel EHG signals, the tocodynamometry (TOCO) signal, and maternal perception were recorded simultaneously by the signal acquisition device controlled by the computer via Bluetooth. PregCare was firstly evaluated by a signal simulator. Its relative error (RE) and coefficient of variation (CV) were calculated, and its agreement with the commercial instrument PowerLab was assessed by Bland–Altman plots. After that, PregCare was applied to 20 pregnant women in a hospital to record their EHG signals. These EHG signals were preprocessed and segmented into UCs and non-UCs. Then, the EHG features corresponding to UCs and non-UCs were extracted, respectively, including power spectral density (PSD), root mean square (RMS), peak frequency (PF), median frequency (MDF), and sample entropy (SamEn). One-way ANOVA was employed to assess the difference between UCs and non-UCs. The results show that RE and CV were less than 8% and 0.03%, respectively, which indicated the high accuracy and repeatability of PregCare. The small differences of mean and standard deviation indicated the high agreement between PregCare and PowerLab. Besides, the PSD of UCs was much larger than non-UCs between 0 and 0.7 Hz. RMS of UCs was significantly larger than non-UCs (p < 0.05). PF and SamEn of UCs were significantly smaller than non-UCs (p < 0.05). In conclusion, the developed EHG recording system was able to record EHG signals reliably. It has the advantages of portability, low power consumption, and wireless transmission, which can be used for long-term monitoring of UCs and prediction of the preterm delivery.

A New Efficient Algorithm for Prediction of Preterm Labor.

Electrohysterogram (EHG) signal represents electrical activity of uterine collected from abdominal surface of pregnant women. It has been proven that EHG analysis could be a suitable way to predict preterm labor and consequently to prevent it. The aim of this paper is to present an efficient low computational complexity algorithm to detect preterm labor using EHG signals. To this purpose, Empirical Mode Decomposition (EMD) has been applied for features extraction. Root mean square (RMS) of first two intrinsic mode function (IMF) of decomposed EHG signals were used as features and classification was performed by Support Vector Machine (SVM). In this experiment, the database consisted of 262 term delivery subjects (duration of pregnancy ≥37 weeks) and 38 preterm delivery subjects (duration of pregnancy <; 37 weeks). Each record contained 3 channels, therefore, various configurations of features and channels were applied. Among those configurations, classification based on RMS of the second IMF from channel one achieved best results with accuracy= 99.56%, sensitivity= 98.95% and specificity= 99.30%.

Analysis of Unipolar and Bipolar 4x4 EHG Signal for Classifying Uterine Contraction

Proper evaluation and detection of uterine contraction is an important treat during gestation period. Uterine contraction happens by the generation of electrical activity from a given myometrial cell to the adjacent cell. There are various methods for monitoring uterine contraction but they lack to distinguish true labour contractions (efficient) from contractions that will not cause delivery (inefficient). One of the most accurate non-invasive technique for monitoring uterine contraction is the uterine electromyogram or Electrohysterogram (EHG). The main aim of this paper is to check whether it is possible to discriminate labour and pregnancy contraction by using 16 electrode database. And also to check bipolar signals give better classification rate than monopolar signals. Result shows that bipolar signal have better performance than monopolar signals.

Characterization of the effects of Atosiban on uterine electromyograms recorded in women with threatened preterm labor

Although research studies using electrohysterography on women without tocolytic therapy have shown its potential for preterm birth diagnosis, tocolytics are usually administered in emergency rooms at the first sign of threatened preterm labor (TPL). Information on the uterine response during tocolytic treatment could prove useful for the development of tools able to predict true preterm deliveries under normal clinical conditions. The aim of this study was thus to analyze the effects of Atosiban on Electrohysterogram (EHG) parameters and to compare its effects on women who delivered preterm (WDP) and at term (WDT). Electrohysterograms recorded in different Atosiban therapy stages (before, during and after drug administration) on 40 WDT and 27 WDP were analyzed by computing linear, and non-linear EHG parameters. Results reveal that Atosiban does not greatly affect the EHG signal amplitude, but does modify its spectral content and reduces the energy associated with the fast wave high component in both WDP and WDT, with a faster response in the latter. EHG signal complexity remained constant in WDT, while it increased in WDP until it reached similar values to WDT during Atosiban treatment. The spectral and complexity parameters were able to separate (p < 0.05) WDT and WDP prior to and during tocolytic treatment and before and after treatment, respectively. The results pave the way for developing better and more reliable medical decision support systems based on EHG for preterm delivery prediction in TPL women in clinical scenarios.

Multivariate Time–Frequency Analysis of Electrohysterogram for Classification of Term and Preterm Labor

Non-invasive electrohysterogram (EHG) could be a promising technique for the preterm birth prediction, which could enable us to diagnose the preterm birth before the labor and reduces the infant mortality and morbidity. Previous studies on the preterm birth prediction with EHG have conducted comprehensive researches on various signal features and classification algorithms, but most of them adopted prefilters based on the linear transforms using fixed basis function, although they are suboptimal for the nonlinearity and nonstationarity of the EHG signal. In this paper, multivariate empirical mode decomposition (MEMD) is applied to decompose the electrical activity signal measured on the uterus. After the decomposition, features are calculated for the corresponding oscillations to the uterine contraction. To investigate the performance of the features, three-channel EHG signals of 254 patients (224 term, 30 preterm) are chosen among 300 patients from Physionet term-preterm electrohysterogram (TPEHG) database to extract features from the EHG signals and classify the features using machine learning algorithms. Classification results shows that the proposed method with MEMD achieved 94.66% correctly classified rate (CCR) and 0.987 area under the curve (AUC), which outperformed those with IIR filter implying MEMD provides a new prospect to improve the current preterm birth prediction approach.

Performance of source imaging techniques of spatially extended generators of uterine activity

Abstract Preterm birth (PTB) is one of the most important complications in pregnancy. Reliable diagnosis means are lacking and the underlying physiological mechanisms are unclear. Determining the location of various correlated and simultaneously active uterus sources from abdominal ElectroHysterogram (EHG) recordings and extracting the corresponding uterus signals is a challenging problem. The use of the EHG for imaging the sources of the uterine electrical activity could be a new and powerful diagnosis technique. In this paper we compare the ability of six distributed source localization methods to recover extended sources of uterus activity from abdominal EHG. As no gold standard to evaluate source localization methods, exists, we perform our evaluation by using a well-controlled realistic simulations of EHG signals, involving several locations. Simulated data were corrupted by physiological EHG noise. The performance of several state-of-the-art techniques for extended source localization is evaluated using a detection accuracy index using the Dipole Localization Error, the Area Under the Receiver Operating Characteristic (ROC) Curve AUC, and the Correlation Coefficient.

A review of significant researches on prediction of preterm birth using uterine electromyogram signal

Abstract Early diagnose for the prevention of preterm birth is one of the important perinatal challenges. The neonatal care and early treatment for preterm babies are increasing the chance of survival, but anyways it affects the respiratory distress, immature brains, cerebral palsy, mental retardation, visual and hearing impairments, and poor health and growth. If preterm labor is diagnosed in the early period of gestation, then it is easy to give an appropriate treatment to the pregnant woman. The uterine electrical activity assessment is a suitable method for monitoring the labor process especially for the prediction of preterm labor. Electrohysterography is a non-invasive technique to monitor the contraction. The electrohysterogram (EHG) or uterine electromyogram (Uterine EMG) is considered as a biomarker for the prediction or preterm labor. A number of studies in this field by various researchers have been reviewed. On the basis of such reviews, this paper provides the different steps such as pre-processing , feature extraction, classifiers and feature subset selection methods for the detection and prediction of preterm birth.

Uterine electromyography for discrimination of labor imminence in women with threatened preterm labor under tocolytic treatment.

As one of the main aims of obstetrics is to be able to detect imminent delivery in patients with threatened preterm labor, the techniques currently used in clinical practice have serious limitations in this respect. The electrohysterogram (EHG) has now emerged as an alternative technique, providing relevant information about labor onset when recorded in controlled checkups without administration of tocolytic drugs. The studies published to date mainly focus on EHG-burst analysis and, to a lesser extent, on whole EHG window analysis. The study described here assessed the ability of EHG signals to discriminate imminent labor (< 7days) in women with threatened preterm labor undergoing tocolytic therapy, using both EHG-burst and whole EHG window analyses, by calculating temporal, spectral, and non-linear parameters. Only two non-linear EHG-burst parameters and four whole EHG window analysis parameters were able to distinguish the women who delivered < 7days from the others, showing that EHG can provide relevant information on the approach of labor, even in women with threatened preterm labor under the effects of tocolytic therapy. The whole EHG window outperformed the EHG-burst analysis and is seen as a step forward in the development of real-time EHG systems able to predict imminent labor in clinical praxis. Graphical abstract The ability of EHG recordings to predict imminent labor (< 7days) was analyzed in preterm threatened patients undergoing tocolytic therapies by means of EHG-burst and whole EHG window analysis. The non-linear features were found to have better performance than the temporal and spectral parameters in separating women who delivered in less than 7days from those who did not.

Characterization and automatic classification of preterm and term uterine records.

Predicting preterm birth is uncertain, and numerous scientists are searching for non-invasive methods to improve its predictability. Current researches are based on the analysis of ElectroHysteroGram (EHG) records, which contain information about the electrophysiological properties of the uterine muscle and uterine contractions. Since pregnancy is a long process, we decided to also characterize, for the first time, non-contraction intervals (dummy intervals) of the uterine records, i.e., EHG signals accompanied by a simultaneously recorded external tocogram measuring mechanical uterine activity (TOCO signal). For this purpose, we developed a new set of uterine records, TPEHGT DS, containing preterm and term uterine records of pregnant women, and uterine records of non-pregnant women. We quantitatively characterized contraction intervals (contractions) and dummy intervals of the uterine records of the TPEHGT DS in terms of the normalized power spectra of the EHG and TOCO signals, and developed a new method for predicting preterm birth. The results on the characterization revealed that the peak amplitudes of the normalized power spectra of the EHG and TOCO signals of the contraction and dummy intervals in the frequency band 1.0-2.2 Hz, describing the electrical and mechanical activity of the uterus due to the maternal heart (maternal heart rate), are high only during term pregnancies, when the delivery is still far away; and they are low when the delivery is close. However, these peak amplitudes are also low during preterm pregnancies, when the delivery is still supposed to be far away (thus suggesting the danger of preterm birth); and they are also low or barely present for non-pregnant women. We propose the values of the peak amplitudes of the normalized power spectra due to the influence of the maternal heart, in an electro-mechanical sense, in the frequency band 1.0-2.2 Hz as a new biophysical marker for the preliminary, or early, assessment of the danger of preterm birth. The classification of preterm and term, contraction and dummy intervals of the TPEHGT DS, for the task of the automatic prediction of preterm birth, using sample entropy, the median frequency of the power spectra, and the peak amplitude of the normalized power spectra, revealed that the dummy intervals provide quite comparable and slightly higher classification performances than these features obtained from the contraction intervals. This result suggests a novel and simple clinical technique, not necessarily to seek contraction intervals but using the dummy intervals, for the early assessment of the danger of preterm birth. Using the publicly available TPEHG DB database to predict preterm birth in terms of classifying between preterm and term EHG records, the proposed method outperformed all currently existing methods. The achieved classification accuracy was 100% for early records, recorded around the 23rd week of pregnancy; and 96.33%, the area under the curve of 99.44%, for all records of the database. Since the proposed method is capable of using the dummy intervals with high classification accuracy, it is also suitable for clinical use very early during pregnancy, around the 23rd week of pregnancy, when contractions may or may not be present.

Uterine contractile efficiency indexes for labor prediction: A bivariate approach from multichannel electrohysterographic records

Abstract Labor prediction is one of the most challenging goals in obstetrics, mainly due to the poor understanding of the factors responsible for the onset of labor. The electrohysterogram (EHG) is the recording of the myoelectrical activity of myometrial cells and has been shown to provide relevant information on the electrophysiological state of the uterus. This information could be used to obtain more accurate labor predictions than those of the currently used techniques, such as the Bishop score, tocography or biochemical markers. Indeed, a number of efforts have already been made to predict labor by this method, separately characterizing the intensity, the coupling degree of the EHG signals and myometrial cell excitability, these being the cornerstones on which contraction efficiency is built. Although EHG characterization can distinguish between different obstetric situations, the reported results have not been shown to provide a practical tool for the clinical detection of true labor. The aim of this work was thus to define and calculate indexes from multichannel EHG recordings related to all the phenomena involved in the efficiency of uterine myoelectrical activity (intensity, excitability and synchronization) and to combine them to form global efficiency indexes (GEI) able to predict delivery in less than 7/14 days. Four EHG synchronization indexes were assessed: linear correlation, the imaginary part of the coherence, phase synchronization and permutation cross mutual information. The results show that even though the synchronization and excitability efficiency indexes can detect increasing trends as labor approaches, they cannot predict labor in less than 7/14 days. However, intensity seems to be the main factor that contributes to myometrial efficiency and is able to predict labor in less than 7/14 days. All the GEIs present increasing monotonic trends as pregnancy advances and are able to identify (p

Detection of preterm labor by partitioning and clustering the EHG signal

Abstract This study aims to predict the risk of preterm labor by analyzing electrohysterogram (EHG). To this purpose, the Term-Preterm EHG Database (TPEHG Database) with 300 EHG signals from pregnant women that are categorized into two classes of term (262) and preterm (38) has been taken into account. This research proposes an algorithm based on time-frequency analysis and thresholding methods for quantitative estimation of uterine contractions. This estimation dismantles the EHG signals into small segments where each segment refers to an event. Then, Linear Predictive Coding (LPC) is applied to extract features from these segments. This study also presents a new approach for classification of term and preterm signal records. To this end, the events were clustered using an unsupervised clustering method and then each cluster was categorized independently to detect term and preterm births. As a result, it was possible to omit the unrelated segments of each record using this approach. The results indicate a significant improvement in separability and accuracy in the preterm birth detection index.

Electrohysterographic characterization of the uterine myoelectrical response to labor induction drugs

Labor induction is a common practice to promote uterine contractions and labor onset. Uterine electrohysterogram (EHG) has proved its suitability for characterizing the uterus electrophysiological condition in women with spontaneous labor. The aim of this study was to characterize and compare uterine myoelectrical activity during the first 4 h in response to labor induction drugs, Misoprostol (G1) and Dinoprostone (G2), by analyzing the differences between women who achieved active phase of labor and those who did not (successful and failed inductions). A set of temporal, spectral and complexity parameters were computed from the EHG-bursts. As for successful inductions, statistical significant and sustained increases with respect to basal period were obtained for EHG amplitude, mean frequency, uterine activity index (UAI) and Teager, after 60′ for the G1 group; duration, amplitude, number of contractions and UAI for the G2 group, after 120′. Moreover, Teager showed statistical significant and sustained differences between successful and failed inductions (1.43 ± 1.45 µV2.Hz2.105 vs. 0.40 ± 0.26 µV2.Hz2.105 after 240′) for the G1 group, but not in the G2 group, probably due to the slower pharmacokinetics of this drug. These results revealed that EHG could be useful for successful induction prediction in the early stages of induction, especially when using Misoprostol.

Comparison of labour induction with misoprostol and dinoprostone and characterization of uterine response based on electrohysterogram

Objective: The objective of this study is to compare the uterine activity response between women administered dinoprostone (prostaglandin E2) and misoprostol (prostaglandin E1) for induction of labour (IOL) by analysing not only the traditional obstetric data but also the parameters extracted from uterine electrohysterogram (EHG).Methods: Two cohorts were defined: misoprostol (25-µg vaginal tablets; 251 women) and dinoprostone cohort (10 mg vaginal inserts; 249 women). All the mothers were induced by a medical indication of a Bishop Score < = 6.Results: The misoprostol cohort was associated with a shorter time to achieve active labour (p = .017) and vaginal delivery (p = .009) and with a higher percentage of vaginal delivery in less than 24 h in mothers with a very unfavourable cervix score (risk ratio (RR): 1.41, IC95% 1.17–1.69, p = .002). Successful inductions with misoprostol showed EHG parameter values significantly higher than basal state for amplitude and pseudo Montevideo units (PMU) 60’ after drug administration, while spectral parameters significantly increased after 150’. This response was not observed in failed inductions. In the successful dinoprostone group, the duration and number of contractions increased significantly after 120’, PMU did so after 180’, and no significant differences were found for spectral parameters, possibly due to the slower pharmacokinetics of this drug.Conclusion: Successful inductions of labour by misoprostol are associated with earlier effective contractions than in labours induced by dinoprostone.

Comparison of electrohysterogram signal measured by surface electrodes with different designs: A computational study with dipole band and abdomen models

Non-invasive measurement of uterine activity using electrohysterogram (EHG) surface electrodes has been attempted to monitor uterine contraction. This study aimed to computationally compare the performance of acquiring EHG signals using monopolar electrode and three types of Laplacian concentric ring electrodes (bipolar, quasi-bipolar and tri-polar). With the implementation of dipole band model and abdomen model, the performances of four electrodes in terms of the local sensitivity were quantified by potential attenuation. Furthermore, the effects of fat and muscle thickness on potential attenuation were evaluated using the bipolar and tri-polar electrodes with different radius. The results showed that all the four types of electrodes detected the simulated EHG signals with consistency. That the bipolar and tri-polar electrodes had greater attenuations than the others, and the shorter distance between the origin and location of dipole band at 20 dB attenuation, indicating that they had relatively better local sensitivity. In addition, ANOVA analysis showed that, for all the electrodes with different outer ring radius, the effects of fat and muscle on potential attenuation were significant (all p < 0.01). It is therefore concluded that the bipolar and tri-polar electrodes had higher local sensitivity than the others, indicating that they can be applied to detect EHG effectively.

ESTIMATION OF INTRAUTERINE PRESSURE FROM ELECTROHYSTEROGRAPHY USING HILBERT PHASE SLIPS AND STATISTICS METHOD

Prognostic information during pregnancy can be obtained by monitoring maternal uterine activity. Tocodynamometry (TOCO) is widely used to assess the uterine activity today but it has been found that it has very low sensitivity. Another method to assess the uterine activity is intrauterine pressure catheter (IUPC) which is accurate but highly invasive. Electrohysterogram (EHG) measured from abdominal surface is a noninvasive method to detect uterine contractions. To reduce motion artifacts of intrauterine pressure (IUP) estimated from EHG signal and further improve the accuracy of contractions detected by IUP estimation, we propose a method to divide the EHG signal into segments by using Hilbert phase slips. Standard deviation (STD) was used to estimate IUP from each EHG signal segment and median filter was used to remove the motion artifacts. The method we proposed was compared with other four methods from literatures. The proposed method results in a higher contractions detection accuracy of EHG-based IUP estimation and a higher correlation coefficient with the IUPC signals compared to other methods which demonstrated the capabilities of the proposed method in reducing motion artifacts of IUP estimation based on abdominal EHG.

Dedicated Entropy Measures for Early Assessment of Pregnancy Progression From Single-Channel Electrohysterography.

Preterm birth is a large-scale clinical problem involving over 10% of infants. Diagnostic means for timely risk assessment are lacking and the underlying physiological mechanisms unclear. To improve the evaluation of pregnancy before term, we introduce dedicated entropy measures derived from a single-channel electrohysterogram (EHG). The estimation of approximate entropy (ApEn) and sample entropy (SampEn) is adjusted to monitor variations in the regularity of single-channel EHG recordings, reflecting myoelectrical changes due to pregnancy progression. In particular, modifications in the tolerance metrics are introduced for improving robustness to EHG amplitude fluctuations. An extensive database of 58 EHG recordings with 4 monopolar channels in women presenting with preterm contractions was manually annotated and used for validation. The methods were tested for their ability to recognize the onset of labor and the risk of preterm birth. Comparison with the best single-channel methods according to the literature was performed. The reference methods were outperformed. SampEn and ApEn produced the best prediction of delivery, although only one channel showed a significant difference () between labor and nonlabor. The modified ApEn produced the best prediction of preterm delivery, showing statistical significance () in three channels. These results were also confirmed by the area under the receiver operating characteristic curve and fivefold cross validation. The use of dedicated entropy estimators improves the diagnostic value of EHG analysis earlier in pregnancy. Our results suggest that changes in the EHG might manifest early in pregnancy, providing relevant prognostic opportunities for pregnancy monitoring by a practical single-channel solution.

Automated detection of premature delivery using empirical mode and wavelet packet decomposition techniques with uterine electromyogram signals

An accurate detection of preterm labor and the risk of preterm delivery before 37 weeks of gestational age is crucial to increase the chance of survival rate for both mother and the infant. Thus, the uterine contractions measured using uterine electromyogram (EMG) or electro hysterogram (EHG) need to have high sensitivity in the detection of true preterm labor signs. However, visual observation and manual interpretation of EHG signals at the time of emergency situation may lead to errors. Therefore, the employment of computer-based approaches can assist in fast and accurate detection during the emergency situation. This work proposes a novel algorithm using empirical mode decomposition (EMD) combined with wavelet packet decomposition (WPD), for automated prediction of pregnant women going to have premature delivery by using uterine EMG signals. The EMD is performed up to 11 levels on the normal and preterm EHG signals to obtain the different intrinsic mode functions (IMFs). These IMFs are further subjected to 6 levels of WPD and from the obtained coefficients, eight different features are extracted. From these extracted features, only the significant features are selected using particle swarm optimization (PSO) method and selected features are ranked by Bhattacharyya technique. All the ranked features are fed to support vector machine (SVM) classifier for automated differentiation and achieved an accuracy of 96.25%, sensitivity of 95.08%, and specificity of 97.33% using only ten EHG signal features. Our proposed algorithm can be used in gynecology departments of hospitals to predict the preterm or normal delivery of pregnant women.