Electrodermal Activity Levels Research Articles

Changes in electrodermal activity following sympathicotomy in hyperhidrosis patients.

The aim of this study was to assess the potential of electrodermal activity (EDA) as a diagnostic tool for preoperative evaluation in hyperhidrosis patients. EDA levels and patterns in different skin areas were investigated before and after endoscopic thoracic sympathicotomy (ETS) and was compared to healthy subjects. Thirty-seven patients underwent two days of measurements before and after the operation. Twenty-five (67.5%) of the patients also had a third measurement after six months. Non-invasive EDA measurements, involving skin conductance, were sampled from five different skin areas while patients were at rest in supine and sitting positions or when subjected to stimuli such as deep inspirations, mental challenge, and exposure to a sudden loud sound. Prior to the operation, hyperhidrosis patients showed higher spontaneous palm EDA variations at rest and stronger responses to stimuli compared to healthy subjects. Patients with facial blushing/hyperhidrosis or combined facial/palmar hyperhidrosis showed minimal spontaneous activity or responses, particularly during mental challenge and sound stimulus. Notably, palm EDA response was abolished shortly following sympathicotomy, although a minor response was observed after six months. Minimal EDA responses were also observed in the back and abdomen postoperatively. Hyperhidrosis patients showed stronger EDA response to stimuli compared to healthy subjects. Sympathicotomy resulted in the complete elimination of palm EDA responses, gradually returning to a limited extent after six months. These findings suggest that EDA recordings could be utilized in preoperative assessment of hyperhidrosis patients.

Electrodermal activity moderates the relationship between depression and suicidal ideation in a group of patients with anxiety and depressive symptoms

PurposeBeing suicide a serious global issue, it's urgent to identify the involved factors and possibly precursors. In our study, it was hypothesized that autonomic hyperactivation might have a moderating role in the relationship between symptoms of depression and suicidal ideation in a group of patients suffering from Mixed Anxiety Depressive Disorder (MADD). MethodsFifty-three outpatients diagnosed with MADD were consecutively recruited. Anxiety and depression levels were assessed through the Symptom Questionnaire whereas suicidal ideation was calculated through specific items extrapolated from the Symptom Checklist-90-R (SCL-90-R). Additionally, Electrodermal Activity (EDA) and the evaluation of Skin Conductance, Level and Response (SCL-SCR), was detected through the recording of a Psychophysiological Stress Profile (PSP). ResultsThe analyses confirmed depression as the first predictor of suicidal thoughts. Nonetheless, EDA levels recorded at baseline and under induced stress exerted a moderating effect on the relationship between thymic deflection and thoughts of death. ConclusionsEven though activation is usually considered a positive factor for clinical prognosis, our findings highlight that autonomic arousal may represent a harmful resource for patients suffering from MADD. The involvement of the psychophysiological axis can accentuate mental suffering and favor suicidal ideation. The need to consider a multidimensional assessment strongly emerged.

Listening Effort in Tinnitus: A Pilot Study Employing a Light EEG Headset and Skin Conductance Assessment during the Listening to a Continuous Speech Stimulus under Different SNR Conditions.

Background noise elicits listening effort. What else is tinnitus if not an endogenous background noise? From such reasoning, we hypothesized the occurrence of increased listening effort in tinnitus patients during listening tasks. Such a hypothesis was tested by investigating some indices of listening effort through electroencephalographic and skin conductance, particularly parietal and frontal alpha and electrodermal activity (EDA). Furthermore, tinnitus distress questionnaires (THI and TQ12-I) were employed. Parietal alpha values were positively correlated to TQ12-I scores, and both were negatively correlated to EDA; Pre-stimulus frontal alpha correlated with the THI score in our pilot study; finally, results showed a general trend of increased frontal alpha activity in the tinnitus group in comparison to the control group. Parietal alpha during the listening to stimuli, positively correlated to the TQ12-I, appears to reflect a higher listening effort in tinnitus patients and the perception of tinnitus symptoms. The negative correlation between both listening effort (parietal alpha) and tinnitus symptoms perception (TQ12-I scores) with EDA levels could be explained by a less responsive sympathetic nervous system to prepare the body to expend increased energy during the "fight or flight" response, due to pauperization of energy from tinnitus perception.

Feasibility of wearable sensors in the NICU: Psychophysiological measures of parental stress

BackgroundParents report elevated stress during their infant's NICU hospitalization. Real-time measures may improve our understanding of parental stress in the NICU. AimExamine the feasibility of wearable sensors to describe parental stress in the NICU. Study designIn this prospective feasibility study of 12 parent-infant dyads, parents wore an Empatica E4 wristband to measure psychophysiological stress via electrodermal activity (EDA) during sensory interventions (holding, massage, reading, touch, etc) with their babies. Baseline and intervention periods were delineated during which concurrent monitoring and clinical observations of infant behavior and environmental factors were recorded. Feasibility was assessed by investigating recruitment/enrollment, retention/adherence, acceptability, sensor usability, and changes in EDA waveforms based on potential stressors. For the latter, independent samples t-tests and ANOVA were used to examine differences in EDA from baseline to intervention, and the impact of environmental and infant factors on parent stress were visually analyzed against EDA waveforms. ResultsWearable sensor use in the NICU appeared feasible as assessed by all methods. Preliminary data analysis indicated that overall parent EDA levels during parent-infant interactions were low, and engagement in sensory intervention(s) led to a non-significant increase in parental EDA, measured by both skin conductance levels and non-specific skin conductance responses. Three main patterns of EDA emerged: a temporary increase in EDA at the beginning of the intervention followed by a decrease and plateau, a plateau in EDA from baseline to intervention, and a gradual rise in EDA throughout intervention. Specific environmental and infant factors, such as infant stress and health care providers entering the room, appeared to impact parent stress levels. ConclusionAlthough these preliminary findings provide support for use of EDA in the NICU, future studies are needed.

Seizure-related differences in biosignal 24-h modulation patterns

A seizure likelihood biomarker could improve seizure monitoring and facilitate adjustment of treatments based on seizure risk. Here, we tested differences in patient-specific 24-h-modulation patterns of electrodermal activity (EDA), peripheral body temperature (TEMP), and heart rate (HR) between patients with and without seizures. We enrolled patients who underwent continuous video-EEG monitoring at Boston Children’s Hospital to wear a biosensor. We divided patients into two groups: those with no seizures and those with at least one seizure during the recording period. We assessed the 24-h modulation level and amplitude of EDA, TEMP, and HR. We performed machine learning including physiological and clinical variables. Subsequently, we determined classifier performance by cross-validated machine learning. Patients with seizures (n = 49) had lower EDA levels (p = 0.031), EDA amplitudes (p = 0.045), and trended toward lower HR levels (p = 0.060) compared to patients without seizures (n = 68). Averaged cross-validated classification accuracy was 69% (AUC-ROC: 0.75). Our results show the potential to monitor and forecast risk for epileptic seizures based on changes in 24-h patterns in wearable recordings in combination with clinical variables. Such biomarkers might be applicable to inform care, such as treatment or seizure injury risk during specific periods, scheduling diagnostic tests, such as admission to the epilepsy monitoring unit, and potentially other neurological and chronic conditions.

Exploring the Emotional Experience During Instant Messaging Among Young Adults: An Experimental Study Incorporating Physiological Correlates of Arousal.

Instant messaging (IM) is a highly diffused form of communication among younger populations, yet little is known about the emotional experience during IM. The present study aimed to investigate the emotional experience during IM by drawing on the Circumplex Model of Affect and measuring heart rate and electrodermal activity as indicators of arousal in addition to self-reported perceived emotional valence. Using an experimental design, we manipulated message latency (i.e., response after 1 min versus 7 min) and message valence (positive versus negative response). Based on data collected from 65 young adults (50% male; Mage = 23.28, SD = 3.75), we observed arousal as participants’ electrodermal activity levels increased from the time a fictitious peer started typing a response to the receipt of that response, especially in the delayed condition. Electrodermal activity levels also increased in both the positive and the negative message conditions. No changes were observed for heart rate. Participants’ self-report perceived emotional valence revealed that positive messages were evaluated as more pleasant and the peer as more available, while no difference in the self-report was found for message latency. These findings shed light on the emotional experience during IM by adding valuable insights on the physiological processes underlying the anticipation of social reward, but only during delayed IM exchange that can be observed in Human–Computer-Interaction.

Does active sitting provide more physiological changes than traditional sitting and standing workstations?

This cross-sectional study examined the physiological effects of two active chairs (AC1: had the feature to pedal and slide forward; AC2: was a multiaxial chair) compared to a traditional office chair and standing workstation. Twenty-four healthy participants computed at each of the workstations for 60 min. The active protocol was to alternate between a pedalling/side-to-side motion and sliding forward/front-to-back motion to the sound of a metronome operating at 40 bpm. The participants' physiological effects were recorded using near-infrared spectroscopy (NIRS); electrodermal activity (EDA) and a heart rate (HR) monitor for each collection period. Statistical analysis was conducted using a repeated measures analysis of variance for within-task and between-workstation comparisons. A Tukey's post hoc analysis was calculated for significant findings. Both active chairs significantly increased oxygenated blood in the gastrocnemius and participants' heart rate and EDA (stress) levels were affected slightly by task and time. However, participants felt more “productive” sitting in the control chair than in either of the active chairs.

Frustration elevates arousal in individuals high on the psychopathy scale: The role of approach, not avoidance motivation

Psychopaths tend to react with aggression when mistreated. The literature offers two contradicting explanations of this subject. The aim of this study is to determine whether approach or (the lack of) avoidance motivation underlie emotional reactions of individuals with elevated psychopathic tendencies in frustrative situations. The sample of sixty participants (43.3% male) participated in the experiment in which the Ultimatum Game was used to induce the feeling of injustice. The participants received four fair offers in the first phase of the game and six unfair offers in the second phase of the experiment. Their electrodermal activity (EDA) was recorded during both parts of the experiment. Along with the EDA recording, the participants fulfilled Short Dark Triad (SD3) questionnaire and Questionnaire of Approach and Avoidance Motivation (QAAM). Generally, the unfair offers significantly elevated EDA in comparison to the levels of EDA during the fair part of the experiment. The mediational analysis conducted by hierarchical regression analysis revealed that psychopathy is associated with a higher EDA in frustrative conditions, which is entirely explained by QAAM wanting, i.e. approach-related scale. Neither of avoidance-related scales predicted the EDA. This result indicates that individuals with elevated psychopathic tendencies experience stronger emotional reactions when facing the potential loss of rewards, which is driven by their stronger approach motivation, and not by the lack of avoidance motivation. Hence, the study contributes to the understanding of the underlying reason for emotional reactions of individuals with elevated psychopathic tendencies in unfair conditions within the approach-avoidance framework. Implications for the methodological setting of future studies on this subject are discussed.

Effect of Exposure Time on Thermal Behaviour: A Psychophysiological Approach

This paper presents the findings of a 6-week long, five-participant experiment in a controlled climate chamber. The experiment was designed to understand the effect of time on thermal behaviour, electrodermal activity (EDA) and the adaptive behavior of occupants in response to a thermal non-uniform indoor environment were continuously logged. The results of the 150 h-long longitudinal study suggested a significant difference in tonic EDA levels between “morning” and “afternoon” clusters although the environmental parameters were the same, suggesting a change in the human body’s thermal reception over time. The correlation of the EDA and temperature was greater for the afternoon cluster (r = 0.449, p < 0.001) in relation to the morning cluster (r = 0.332, p < 0.001). These findings showed a strong temporal dependency of the skin conductance level of the EDA to the operative temperature, following the person’s circadian rhythm. Even further, based on the person’s chronotype, the beginning of the “afternoon” cluster was observed to have shifted according to the person’s circadian rhythm. Furthermore, the study is able to show how the body reacts differently under the same PMV values, both within and between subjects; pointing to the lack of temporal parameter in the PMV model.

Self-reported playing preferences resonate with emotion-related physiological reactions during playing and watching of first-person shooter videogames

The present aim was to investigate emotion-related physiological responses and subjective ratings of two groups of active gamers (N = 24) in response to both playing and watching a video of a first-person shooter game. Participants of one group had high preferences for game dynamics in first-person shooter games, whereas the other group disliked such dynamics. Electrodermal activity (EDA), heart rate (HR), and electromyographic (EMG) activity of the corrugator supercilii (i.e., brow furrowing) and the zygomaticus major (i.e., smiling) muscles were measured while playing and watching a gameplay video. After the playing and watching sessions, the participants rated their experienced level of valence and arousal. The results showed that those who liked the game dynamics showed comparable and stable levels of EDA and HR during both playing and watching. Those who disliked the game dynamics showed overall higher levels of EDA and HR during playing than watching a video, and a rising EDA tendency especially during watching a video. Playing evoked overall higher corrugator supercilii activity than watching in both groups. The group that liked the game dynamics showed a steep EMG increase in the activity of the corrugator supercilii, whereas the group that disliked the game dynamics showed less EMG increase. As for ratings of valence and arousal, both groups reported more positive valence and higher arousal after playing than after watching a video, and there were no differences between the groups. In sum, the results showed that player preferences were associated with players’ emotion-related physiological responses. The results also showed that playing as opposed to watching generated higher autonomic arousal, but only for players who disliked the dynamics of the game.

Emotional Behavioural and Autonomic Dysregulation (EBAD) in Rett Syndrome – EDA and HRV monitoring using wearable sensor technology

BackgroundRett syndrome (RTT) is a severe genetic neurodevelopmental disorder. Emotional, Behavioural and Autonomic Dysregulation (EBAD), is frequent in RTT and is associated with multiple impairments. There are major challenges in the clinical assessment of emotions, behaviours, and autonomic function in RTT patients that limit the management of symptoms. MethodsWeb-based technology (HealthTracker™) to measure the phenotype, and non-invasive, wearable sensor technology to evaluate autonomic function through Electrodermal Activity (EDA) and Heart Rate Variability (HRV) in 10 RTT patients was used, and treatment response of EBAD symptoms was monitored after different pharmacological treatments. Resultsand discussion: 4 patients received buspirone, 2 sertraline, 1 gabapentin and 3 were not started on medications. Buspirone normalized the EDA in 3 patients with associated improvement in EBAD, whilst another patient only improved marginally. Both patients treated with sertraline (including one with normal EDA) significantly improved symptomatically. The patients on unchanged regimens showed no change in symptoms and autonomic function. Within 24 h of our assessment, one patient required intensive inpatient care due to septicaemia – this patient had been on gabapentin and showed a sharp and sustained EDA increase without obvious worsening of emotional and behavioural symptoms. Unlike the EDA, the analyses of HRV metrics did not reveal patterns that were associated with clinical outcomes. Our findings suggest a reasonable association of EDA normalization and symptomatic improvement in RTT subjects with EBAD treated with buspirone and point out its potential application as a measure of dysautonomia in RTT. Very high and sustained EDA levels may be a biomarker for concurrent serious physical illness in RTT.

Electrodermal activity – a promising biomarker for cardiovascular risk assessment in adolescent anorexia nervosa

Introduction Anorexia nervosa (AN) represents a severe mental disorder associated with cardiovascular complications leading to morbidity and mortality. Abnormal functioning of autonomic nervous system, particularly sympathetic nervous system, plays a crucial role in AN-linked psychopathology and cardiovascular diseases; however, the pathomechanisms are still unclear.ObjectivesThus, we studied sympathetic arousal in response to mental stress using conventional parameters, and for the first time by spectral analysis of electrodermal activity with aim to detect non-invasive biomarkers for cardiovascular risk assessment already in adolescent AN patients.MethodsTwenty-five AN girls were examined (14.8±0.4 yr.) and age/gender matched controls (15.1±0.3 years). Electrodermal activity (EDA) was continuously recorded at rest (5 min.) and in response to Go/NoGo test (5 min.). Evaluated parameters: skin conductance level (SCL) and spectral parameter of EDA in the sympathetic frequency band (EDASymp). EDA reactivity was calculated as percentual change (%) of SCL and EDASymp in response to stressor.ResultsThe AN group had significantly reduced SCL and EDASymp compared to controls during baseline (p=0.041, p=0.0001, respectively) and in response to Go/NoGo test (p=0.043, p=0.017, respectively). The EDASymp index reactivity was significantly lower in AN group compared to control (p=0.034).Conclusions Our study revealed resting sympathetic underactivity associated with lower reactivity to mental stressor indexed by EDA parameters in adolescent AN patients. This altered pattern of sympathetic arousal could play important role as a pathomechanism leading to cardiovascular complications in AN. It seems that EDA indices represent potential non-invasive biomarkers to detect AN-linked cardiovascular risk already at adolescent age.Conflict of interestThis study was funded by the Slovak Scientific Grant Agency under grants VEGA 1/0044/18 and VEGA 1/0190/20 and Ministry of Health of the Slovak Republic under the project registration number 2018/20-UKMT-16.

Twenty-four-hour patterns in electrodermal activity recordings of patients with and without epileptic seizures.

Daytime and nighttime patterns affect the dynamic modulation of brain and body functions and influence the autonomic nervous system response to seizures. Therefore, we aimed to evaluate 24-hour patterns of electrodermal activity (EDA) in patients with and without seizures. We included pediatric patients with (a) seizures (SZ), including focal impaired awareness seizures (FIAS) or generalized tonic-clonic seizures (GTCS), (b) no seizures and normal electroencephalography (NEEG), or (c) no seizures but epileptiform activity in the EEG (EA) during vEEG monitoring. Patients wore a device that continuously recorded EDA and temperature (TEMP). EDA levels, EDA spectral power, and TEMP levels were analyzed. To investigate 24-hour patterns, we performed a nonlinear mixed-effects model analysis. Relative mean pre-ictal (-30min to seizure onset) and post-ictal (I: 30min after seizure offset; II: 30 to 60min after seizure offset) values were compared for SZ subgroups. We included 119 patients (40 SZ, 17 NEEG, 62 EA). EDA level and power group-specific models (SZ, NEEG, EA) (h=1; P<.01) were superior to the all-patient cohort model. Fifty-nine seizures were analyzed. Pre-ictal EDA values were lower than respective 24-hour modulated SZ group values. Post hoc comparisons following the period-by-seizure type interaction (EDA level: =18.50; P<.001, and power: =6.73; P=.035) revealed that EDA levels were higher in the post-ictal period I for FIAS and GTCS and in post-ictal period II for GTCS only compared to the pre-ictal period. Continuously monitored EDA shows a pattern of change over 24 hours. Curve amplitudes in patients with recorded seizures were lower as compared to patients who did not exhibit seizures during the recording period. Sympathetic skin responses were greater and more prolonged in GTCS compared to FIAS. EDA recordings from wearable devices offer a noninvasive tool to continuously monitor sympathetic activity with potential applications for seizure detection, prediction, and potentially sudden unexpected death in epilepsy (SUDEP) risk estimation.

Mapping of electrodermal activity (EDA) during outdoor community-level mobility tasks in individuals with lower-limb amputation.

IntroductionBalance confidence and perception of task challenge is an important construct to measure in rehabilitation of people with lower-limb amputation (LLA). Measurement of electrodermal activity (EDA) captures physiological arousal responses reflecting an individual’s perceived challenge in a task. This study explores the feasibility of the use of EDA during outdoor walking tasks to capture task-specific physiological arousal changes associated with perception of challenge in people with amputation.ObjectiveTo develop and demonstrate feasibility of a portable EDA/GPS system mapping physiological arousal while challenging walking balance outdoors in individuals with LLA and controls.MethodsSixteen people (eight with LLA and eight age-/sex-matched controls) completed an outdoor walking course in the community (3 laps). A battery-powered portable device was developed containing EDA/GPS sensors with data logged on a microcontroller. Phasic EDA response was extracted from EDA signal to explore the physiological arousal response to walking tasks.ResultsPhysiological arousal demonstrated task-specific modulation with ascending stairs without a handrail showing higher levels of phasic EDA than walking on a paved incline (p = 0.01) or a gravel decline (p = 0.01) in people with LLA. While evidence of habituation over repeated trials was shown in controls with lap 1 of walking down a gravel decline showing higher levels of phasic EDA than lap 3 (p = 0.01). Phasic EDA maps, representative of arousal levels throughout the walking course, showed individual-specific response.ConclusionMapping of EDA during outdoor walking is feasible. Modulation of physiological arousal between outdoor walking tasks and over repeated trials is suggestive of clinical utility. Further research is warranted to explore how EDA may be incorporated into assessment of response to outdoor walking amongst individuals following LLA.

Unusual suspects: Real-time physiological evaluation of stressors during laparoscopic donor nephrectomy.

The purpose of this study was to document the variability of faculty surgeon electrodermal activity (EDA) peaks during laparoscopic donor nephrectomy (LDN) to determine the effect of case difficulty and learner expertise on the stress response. EDA for a single faculty surgeon was captured over 15 LDN cases using an Empatica E4 wristband. During each case, one of three transplant fellows (novice, intermediate, or expert level LDN expertise) participated. Difficulty was rated preoperatively as "low/moderate/high" by the faculty. EDA peaks were collected and analyzed; the frequency and magnitude of EDA peaks, case difficulty, and fellow expertise were compared using a two-way factorial ANOVA. The main effects of learner expertise (F[2, 308]=11.27, p<0.001) and difficulty rating (F[2, 414]=15.13, p<0.001) were significant. The interaction between difficulty and expertise on faculty EDA peaks was also significant (F[3, 391]=14.29, p<0.001). The novice fellow resulted in higher faculty EDA levels compared to intermediate and expert fellows on low-difficulty cases, but not moderate- or high-difficulty cases. This is the first report examining faculty surgeon EDA across cases of varying difficulty and varying learner expertise during a high-stakes operation. EDA levels were inversely proportional to the expertise of the learner and case difficulty, suggestive of a significant impact of learner autonomy on faculty stress response.

Electrodermal Correlates of Hypnosis: Current Developments

Hypnosis has proven to be an effective treatment in disorders that affect the autonomic nervous system (ANS). However, the studies investigating the nature of its effect on the ANS have reported contradictory results. Measurement of electrodermal activity (EDA) is an objective way to assess the activity of the sympathetic branch of the ANS. We aim to elucidate the effects of hypnosis on EDA. Here, we report the results of two studies, both investigating the psychophysiological effects of hypnosis.In the first experiment, subjects engaged in an HGSHS:A group hypnosis session to measure their hypnotizability. EDA was measured bilaterally from their wrists. We found a significant reduction in EDA levels and the number of nonspecific responses during the hypnotic induction phase. This effect was observed in all three hypnotizability groups—high, medium, and low hypnotizables. A three-way interaction confirmed that EDA patterns on the left and right sides were characteristically different in these three groups. Left-side dominance was typical in high hypnotizables, whereas low hypnotizables were characteristically right-sided. EDA levels of the two sides remained synchronous in medium hypnotizables. During the suggestion phase, we found significant differences in EDA levels depending on the test suggestions, modulated by hypnotizability. A suggestion, harder to respond to, elicited higher arousal in high hypnotizables as compared to low hypnotizables. In the second experiment, we performed five consecutive hypnosis sessions to confirm the reproducibility of the most prominent effect found in Study 1—a gradual decrease in the level of skin conductance during hypnotic induction. We also confirmed that this effect is independent of the hypnotizability level. We conclude that arousal is bilaterally reduced during hypnosis induction, which is persistent across different levels of hypnotizability. At the same time, lateral differences define unique EDA patterns in the induction phase, characterizing high, medium, and low hypnotizables.

Decreased electrodermal activity in patients with epilepsy

ObjectiveBiofeedback therapy using electrodermal activity (EDA) is a new noninvasive therapy for intractable epilepsy. However, the characteristics of EDA in patients with epilepsy are little known; therefore, we assessed the EDA characteristics in patients with epilepsy. MethodsA cross-sectional observational study was conducted in 22 patients with epilepsy and 24 healthy individuals. We collected information on demographic characteristics, EDA, and state anxiety from both groups, and epilepsy diagnosis, seizure number per month, disease duration, and number of antiepileptic drugs (AED) from the epilepsy group. A wristband device was used to measure resting EDA from both wrists for 10 min under controlled temperature and humidity. We compared the EDA levels between the epilepsy group and the control group and examined correlations between EDA and epilepsy-associated factors in the epilepsy group. ResultsA decreasing trend in EDA was observed during the first 1 min from the start of the measurement in 22 patients with epilepsy (with or without seizures) compared with healthy controls (P = 0.12). However, a significant decrease in EDA was found in 18 patients with epilepsy with seizures compared with healthy controls (−0.48 versus −0.26; P = 0.036). Furthermore, seizure frequency showed a significant inverse correlation with EDA in the epilepsy group (ρ = −0.50, P = 0.016). However, neither disease duration nor the number of drugs prescribed correlated with EDA in the epilepsy group . SignificanceMarginally decreased EDA was observed in patients with epilepsy, and significantly decreased EDA was found in patients with a higher seizure frequency. The present findings shed light on the appropriateness of EDA-biofeedback therapy in epilepsy.

Family-of-origin aggression, dating aggression, and physiological stress reactivity in daily life

Individuals exposed to aggression and who perpetrate aggression against others show differences in their physiological activation during stress; the goal of the present study is to investigate physiological stress reactivity as a factor contributing to the intergenerational transmission of aggression. To test associations between family-of-origin aggression (FOA), physiological reactivity in daily life, and dating aggression perpetration, we used ecological momentary assessment to monitor fluctuations in young adult (Mage = 23.1 years) dating couples' electrodermal activity (EDA) over an entire day and examined how naturally-occurring bouts of annoyance between partners relate to EDA, FOA, and dating aggression perpetration. Dating perpetration was linked to lower general levels of EDA in both men and women, while FOA was linked to lower general levels of EDA in men only. For women, multi-group, multilevel models showed that FOA and dating aggression perpetration moderated the association between feeling annoyed and EDA, such that those with greater FOA and dating aggression perpetration showed greater EDA reactivity during naturally-occurring relationship stress. Furthermore, this pattern of EDA reactivity mediated the link between FOA and dating aggression perpetration in women. These results provide evidence that FOA and dating aggression perpetration are linked to patterns of physiological responsivity in everyday life and suggest that these patterns could be important factors contributing to the intergenerational transmission of aggression.

Blending active and passive digital technology methods to improve symptom monitoring in early psychosis.

Psychotic symptoms fluctuate over time and effective and regular monitoring may contribute to relapse prevention and improve long-term outcomes. In this proof-of-concept study we test the feasibility, acceptability and potential usefulness of a novel digital method assessing the association between physiological signals and psychotic symptom distress. Fifteen participants with first episode psychosis were asked to use a self-assessment mobile phone application for psychotic symptom monitoring for 10 days while using a wrist worn device continuously recording heart rate variability (HRV) and electrodermal activity (EDA). We compared physiological activity when participants reported experiencing distressing and non-distressing psychotic symptoms. Participants completed on average 76% of the mobile phone symptom assessments. When reporting distressing hallucinations and delusions participants had significantly higher EDA levels and non-significant lower HRV values compared to when these symptoms were non-distressing. This study provides further evidence linking psychotic symptom's distress, as experienced in everyday life, and autonomic deregulation. This proof-of-concept study may lead to further longer-term efforts to identify relapse biosignatures using automated methods based on passive monitoring. This method may allow for earlier interventions, contribute to improve relapse prevention and reduce symptoms interfering with recovery.

Impact of obesity and gender differences on electrodermal activities.

The widespread use of electrodermal activity (EDA) as a measuring tool in sympathetic nervous system activity researches has resulted in a wide variety of publications on EDA. Yet, the influences of obesity and gender differences in the responses and levels of EDA have not been studied carefully. This study aims to investigate the impacts of obesity and gender differences on EDA parameters. To this end, EDA responses and levels were recorded from 36 (18 males and18 females) apparently healthy adult subjects nearly half of them are obese. EDA measures were induced by three different stimuli and the EDA responses and levels were compared as a function of obesity and gender differences for all stimuli. It was found that EDA parameters, in particular, skin conductance responses (SCRs) were significantly different between obese and non-obese subjects for both genders. In addition, it was found that the change in skin susceptance levels (SSLs) was statistically significant only among females. The investigation also showed that the gender difference has a crucial role in skin potential levels (SPLs) for obese subjects. The outcome results led to the conclusion that the phasic SCRs were strongly related to BMI, while tonic SPLs were related to gender differences.