Electrochemical Determination Research Articles

Electrochemical determination of nitazoxanide in environmental and pharmaceutical samples using a boron-doped diamond electrode

Consumption of Nitazoxanide (NTZ), a compound belonging to the class of nitrothiazoles, has increased due to its efficiency in treating viral gastroenteritis caused by rotavirus and norovirus “coronavirus disease”. Thus, developing a method capable of monitoring NTZ in wastewater and pharmaceutical formulations is relevant to human health control. However, most methods for NTZ determination are expensive and time-consuming. Hence, we present a fast, efficient, and low-waste method for NTZ monitoring in drugs and water samples using a boron-doped diamond electrode. A 3D-printed electrochemical cell with a capacity of 2 mL was used for all studies. Besides the simplicity of low waste generation, the method provided good analytical performance with a linear range of 2.0–20.0 µmol/L of NTZ, and a limit of detection (LOD) of 0.57 µmol/L. Recovery percentages between 99 and 107 % were obtained to analyze spiked samples. In addition, we demonstrate that the LOD value can be significantly improved by 50 times after applying a pre-concentration step using solid-phase extraction. Therefore, we believe the described approach is a simple and efficient electrochemical method for monitoring NTZ levels in pharmaceutical and environmental samples without laborious sample preparation procedures. This is the first report to describe the use of BDD electrodes for NTZ monitoring and environmental sample analysis using an eco-friendly approach.

Integrated tetrahydroxyphthalocyanine-coated graphene decorated with ionic liquid-functionalized gold nanoparticles for highly sensitive and selective electrochemical determination of ascorbic acid in fruit juices.

Surface functionalization and the combined utilization of zero-dimensional and two-dimensional nanomaterials is an effective method to achieve highly sensitive detection for electrochemical analysis. Using an all-in-one strategy, phthalocyanine, gold nanoparticles, and ionic liquid were successively modified on the graphene surface as a highly integrated electrode modification material. Phthalocyanine can repair the defects of reduced graphene oxide by binding to the graphene structure surface through non-covalent functionalization. The combination of ionic liquid on the surface of gold nanoparticles can enhance their physical and chemical activity while preserving their stability. The obtained phthalocyanine-coated graphene nanosheets decorated with ionic liquid-functionalized gold nanoparticles nanocomposites had enhanced electrocatalysis and conductivity ability, and were used for highly sensitive electrochemical detection of ascorbic acid in fruit juices. Excellent results were obtained for the detection of ascorbic acid in thelinear range 0.05 to 50µmol/L with a detection limit of 6.80nmol/L (S/N = 3) and a sensitivity of 2.68μA μM-1cm-2, indicated that the proposed sensor strategy with multiple signal amplification can achieve higher detection sensitivity. Furthermore, the sensor was used to quantify ascorbic acid content in grapefruit and orange juice with good selectivity and accuracy. The highly integrated electroactive nanocomposites construction method described may also be used with other electrode modification materials and is anticipated to yield fresh perspectives on the advancement of ultrasensitive detection.

Fabrication of nickel oxide/copper cobaltite/graphene quantum dot conductive ink as an electrode material for selective electrochemical detection of epinephrine

Wearable sensors and flexible electrodes are key components of point-of-care systems, facilitating enhanced accessibility and personalization in health monitoring. These technologies permit individuals to oversee their health status and enable healthcare professionals to remotely and in real time monitor patients’ health status more effectively. In this study, paper-based flexible screen-printed electrodes were constructed for the electrochemical determination of epinephrine (EP), which is crucial in the diagnosis of various diseases, with high selectivity and low detection limits. In a novel approach, nickel oxide (NiO), graphene quantum dots (GQD), and copper cobaltite (CuCo2O4) were employed in conjunctions for the first time in the development of conductive ink. The large surface area and high electrical conductivity of GQD, when combined with the electrocatalytic properties of NiO and CuCo2O4, resulted in the creation of a more efficient electroactive environment for electrochemical EP determination. The differential pulse voltammetry technique enabled the attainment of a limit of detection (LOD) of 11.66 nM within the 500–10 µM and 2–0.02 µM linear ranges. The reduction peak current of EP was examined throughout the analysis to eliminate the effects of possible interference species that may be present in real samples. Furthermore, the stable structures of GQDs and copper cobaltite enhanced the long-term performance of the sensors, and the combination of these materials increased the reproducibility and reliability of the sensors. Subsequently, the efficacy of the sensor was evaluated using real samples, specifically artificial sweat, and urine. The developed NiO/CuCo2O4/GQD/G/SPE sensor demonstrated satisfactory recovery values, with 94.5–110.5 %.

Exploring Botryosphaeran, a (1 → 3)(1 → 6)-β-D-Glucan, as a Matrix for the Stabilization of Laccase from Pleurotus ostreatus Florida onto a Zinc Oxide Quantum Dots Platform for the Electrochemical Determination of 2,6-Dimethoxyphenol.

This work describes the development of a novel biosensor obtained by immobilizing laccase from Pleurotus ostreatus Florida onto a glassy carbon electrode platform modified with zinc oxide quantum dots. For enzyme immobilization, the exopolysaccharide botryosphaeran from Botryosphaeria rhodina MAMB-05 was used. Although both biomaterials are from different fungal sources, laccase immobilization was guaranteed, which was demonstrated by the excellent stability of the fabricated biosensor device for the voltammetric determination of 2,6-dimethoxyphenol (2,6-DMP). Under the optimal experimental conditions, the cathodic current from the square-wave voltammograms presented a linear dependence on the 2,6-DMP concentration within the range of 10-400 nmol L-1, with a limit of detection of 9 nmol L-1. This bioanalytical device exhibited excellent repeatability and long-term storage stability.

Electrochemical Determination of Type-Specific Antigens (TSA) Associated with Orientia tsutsugamushi (Scrub Typhus) by a Graphene Quantum Dot (GQD)-Modified Screen-Printed Paper Electrode (SPPE)

Graphene quantum dots (GQDs) were used for surface modification of a screen-printed paper electrode (SPPE) for the development of a mobile phone-integrated immunosensor for the detection of scrub typhus. GQDs were synthesized from a 1.8% starch solution via a hydrothermal method and characterized by ultraviolet–visible (UV–Vis) spectroscopy, fluorescence, Fourier transform infrared spectroscopy and dynamic light scattering. Furthermore, anti-56 kDa type specific antigen (TSA) antibodies were used for immobilization on the GQD-modified SPPE working electrode using EDC/NHS (N-ethyl-N′-(3-(dimethylamino)propyl)carbodiimide/N-hydroxysuccinimide) (1:1) chemistry. The TSA antigen was used at different concentrations to interact with specific antibodies, and the response was recorded via cyclic voltammetry, differential pulse voltammetry and electrochemical impedance spectroscopy using potassium ferricyanide K4[Fe(CN)6]− as a redox indicator. The developed immunosensor showed an excellent sensitivity of 17.40 µA cm−2 ng−1 and a limit of detection of 0.399 ng µL−1. The developed immunohybrid sensor is a novel mobile phone-integrated, highly specific and stable platform for Orientia tsutsugamushi.

Anisotropic gold nanostructure-mediated electrocatalysis on exfoliated GCN: A shape-dependent study

The growth of anisotropic gold nanostructures on exfoliated GCN(E-GCN) surface and the resulting shape dependent electrocatalytic activity towards ascorbic acid (AA), dopamine (DA) and hydrogen peroxide (HP) were investigated in this present study. The SEM images of Au deposited on GC surface shows anisotropic structures after 120 min deposition. On the other hand, Au deposited on E-GCN after 15 min shows flower like structure (GCE/E-GCN-FL-Au) and it remains unchanged up to 60 min. The flower like morphology was changed to distorted hexagonal morphology after 120 min deposition (GCE/E-GCN-DH-Au) Here, citric acid (CA) can act as a reducing agent for the reduction of Au3+ to Au0. The obtained morphological changes of Au on the surface of E-GCN in contrast to GC plate, reveal that the GCN surface can act as a shape directing agent. The electroactive surface area (EAS) of the GCE/E-GCN-DH-Au was greater than the EAS of the GCE/E-GCN-FL-Au. The influence of Au shape on AA and DA oxidation and HP reduction was also investigated. In terms of electrochemical determination towards AA, DA and HP, the GCE/E-GCN-DH-Au outperformed the other modified electrodes. The GCE/E-GCN-DH-Au proved to be a useful tool for sensitive determination of HP with the LOD of 0.75 nM (S/N=3).

Low-Cost Electrochemical Determination of L-Ascorbic Acid Using Screen-Printed Electrodes and Development of an Electronic Tongue for Juice Analysis

Low-cost electrochemical methodologies for the determination of L-ascorbic acid (vitamin C) and the analysis of juices are developed based on its electro-oxidation on carbon screen-printed electrodes. A novel chronoamperometric methodology is developed for the quantification of L-ascorbic acid in fruit juices. The proposed method stands out for its simplicity and rapidity, demonstrating its efficacy in determining L-ascorbic acid content in various fruit juices. Notably, the results obtained with this chronoamperometric approach are compared with those yielded by chromatography, with no significant differences between the two methods being found. Additionally, an electronic tongue is developed for the differentiation of juices based on the square wave voltammetric signals.

Development of CuFe2O4 microspheres/carbon sheets composite materials as a sensitive electrochemical sensorfor determination of bisphenol A.

A composite material based on CuFe-ZIF-derived CuFe2O4 nano-microspheres grown in situ and well-ordered on carbon sheets (CS) was prepared and applied for highly effective determination of bisphenol A (BPA). The composite material possessed inherently high redox activity due to the presence of both Cu and Fe ions with various oxidation states (Cu²⁺/Cu⁺ and Fe³⁺/Fe²⁺), high specific surface area, uniform distribution of Cu and Fe ions, and a robust framework imparted by its precursor CuFe-ZIF. Thisled to increased active sites for electrochemical reactions, improved electron transfer efficiency, and structural integrity during electrochemical cycling. Furthermore, combining CS with CuFe2O4 not only provided a large surface area to support well-ordered CuFe₂O₄ nano-microspheres without aggregation, but also enhanced the conductivity and mechanical stability of the CuFe₂O₄/CS composite. This results in synergistic effects that enhanced the overall performance of the composite material. In addition, both copper and iron are relatively non-toxic and abundant, making CuFe₂O₄/CS safe and cost-effective for large-scale applications. Consequently, the CuFe2O4/CS-modified electrode shows highly efficient electrochemical sensing properties with a wider detection range of 0.009-168 µM and lower detection limit of 0.0027 µM (S/N = 3) compared withmost reported BPA sensors. It also hasanoptimized current at pH 7 which is convenient for real world applications. This CuFe2O4/CS modified electrode as a highly sensitive electrochemical platform can be applied to monitor BPA concentrations in bottled water with good recovery (97.2-102.2%).

Exceptional proton conduction in two robust zirconium(IV)/hafnium(IV)-organic frameworks constructed by tetratopic carboxylate

The fabrication of metal-organic frameworks based on zirconium and hafnium with high structural rigidity using multifunctional carboxylate and the examination of their possible uses have gained significant attention in recent times. The structural features of these porous MOFs, such as their abundant Lewy acid sites and hydroxyl groups, which are appropriate for building effective proton transport channels, have also drawn much attention in the proton conduction field. Herein, two highly stable Zr(IV)/Hf(IV) MOFs, [M6(μ3-O)4(μ3-OH)4(bptc)3]·2DMF (M = Zr (Zr-bptc) or Hf (Hf-bptc)) were solvothermally prepared by employing the tetratopic ligand, 3,3′,5,5′-biphenyltetracarboxylic acid (H4bptc), in which M6(μ3-O)4(μ3-OH)4(COO)12 clusters are linked by bptc3- anions to form an ftw type framework with 12-connected M6 cluster. X-ray powder diffraction, infrared spectroscopy, scanning electron microscopy, and thermogravimetric analyses proved that the two MOFs had remarkable water, chemical, and thermal stability. The alternating current (AC) impedance determinations manifested that the two MOFs have high proton conductivities under 100 °C and 98 % relative humidity (RH) of 0.89 × 10−3 and 1.37 × 10−3 S/cm, respectively, which are among the described MOFs with high proton conductivity. Furthermore, the two MOFs demonstrated excellent electrochemical determination durability. In addition, the activation energy estimates at high or low RHs fully illustrated the significant influence of water molecules in the environment on proton transport within the framework. This investigation again confirms that Zr/Hf-based MOFs have unparalleled structural and performance advantages in energy chemistry.

Highly sensitive electrochemical determination of agomelatine in biological samples based on Cu nanoparticles/Schiff base network1 modified glassy carbon electrode: DFT and experimental studies

In this study, a nanocomposite of copper nanoparticles incorporated into a covalent organic framework (Cu@SNW1) was synthesized and characterized by various approaches such as scanning electron microscopy, cyclic voltammetry, X-ray diffraction, electrochemical impedance spectroscopy, and energy dispersive X-ray spectroscopy. The interaction between the nanocomposite and agomelatine (AGM) was investigated through density functional theory computations. The results indicated that the nanocomposite displays electrocatalytic properties towards AGM and their interactions are both experimentally and thermodynamically viable. The synthesized nanocomposite was employed as an electrocatalytic modifier for the highly selective and sensitive square wave anodic stripping voltammetric detection of AGM. Experimental parameters including; pH, deposition time, modifier concentration, and deposition potential were fine-tuned using the Box-Behnken experimental design strategy. Under the optimal conditions, a linear correlation was established between the anodic peak current of AGM and its concentration across two linear ranges, 0.007–1.00 μmol L−1 and 1.00–6.50 μmol L−1. The method demonstrated a limit of detection of 0.002 μmol L−1 under the optimized parameters. Furthermore, the proposed method exhibited high sensitivity and selectivity in determining AGM in urine, serum, and saliva samples.

Utility of Gold/Multiwalled Carbon Nanocomposite for Electrochemical Determination of Omarigliptin in Tablets and Human Plasma

Abstract An innovative voltammetric sensor was developed to estimate omarigliptin, a novel long-acting anti-diabetic drug. The sensor utilized a carbon paste electrode enhanced with a nanocomposite of carbon nanotubes and electrodeposited gold nanoparticles. The modified electrode was characterized using scanning electron microscopy and electrochemical impedance spectroscopy. The modification significantly improved the electrode's sensitivity and electrochemical efficiency and decreased its electron transfer resistance. The surface area of the modified electrode increased by about 2.8-fold compared to the bare electrode. Omarigliptin's oxidation behavior on the modified electrode was pH-dependent and irreversible, resulting in a peak current 4 times higher than the unmodified electrode. The modified electrode revealed good reproducibility, reusability, and stability. It allows for sensitive voltammetric analysis of omarigliptin over a linear range of 0.4–27 µM (LOD=0.12 µM) and good applicability in tablets and plasma. The recovery percentages are 98.47–101.27% in tablets and 95.86–105.02% in plasma. The modified electrode exhibits good selectivity towards OMR without interference from tablet excipients, endogenous plasma components, and co-administered drugs. The comparison with the reported methods reveals the superiority of the proposed method in terms of sensitivity, selectivity, applicability, and eco-friendliness. Finally, the proposed method demonstrates excellent environmental profiles based on recent assessment metrics.

Highly efficient electrocatalysts of NiMoO4 doped CdO nanostructure interconnected with modified glassy carbon electrode for the detection of chloramphenicol

In this study, we developed an excellent electrocatalyst of NiMoO4 doped with CdO and then coated electrochemical detection of chloramphenicol (CAP) via a glassy carbon electrode (NiMoO4@CdO/GCE). In particular, this drug treats typhoid, fever, and salmonellosis infections. CAP detection and measurements have become progressively important in ensuring human safety. The NiMoO4@CdO nanocomposite was prepared using the one-step hydrothermal method and characterized for its structural and optical properties. The electrochemical determination of CAP was investigated using cyclic voltammetry (CV), differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS) techniques. We observed that the glassy carbon electrode modified with NiMoO4@CdO efficiently reduced the CAP at a very low potential. While CAP interacts with this system, metal oxide nanocomposites can combine with CAP reduction to produce phenylhydroxylamine. According to the DPV analysis, the bare electrode provides a linear response in the 10–100 µM range and a substantial reduction in CAP over a low detection limit of 0.083 µM when compared to (NiMoO4@CdO/GCE). Other co-existing molecules challenge the utility of this sensor. Additionally, this sensor exhibited high selectivity, stability, and reproducibility. Further, we evaluated the sensor for real-sample analysis, and the results were satisfactory.

Electrochemical determination of 5-heneicosylresorcinol using a disposable molecularly imprinted polymer-modified screen-printed electrode

Alkylresorcinols serve as critical biomarkers for whole-wheat grains, and their precise analysis is essential for authenticating and monitoring the quality of whole-wheat products. In this study, we developed a novel electrochemical sensor by using a disposable screen-printed electrode for the sensitive and selective detection of 5-heneicosylresorcinol (AR21). To enhance the sensor’s sensitivity and selectivity, multilayered Ti3C2Tx (m-Ti3C2Tx) nanomaterials were incorporated into the electrode in conjunction with molecularly imprinted polymers. Under optimized conditions, the sensor exhibited a linear detection range of 0.005 to 100 mg·L−1, with a detection limit of 3.98 μg·L−1 for AR21. Furthermore, the sensing platform demonstrated remarkable selectivity for AR21 when compared to structurally similar compounds, along with excellent reproducibility and stability. Validation studies with real wheat food samples confirmed the effectiveness of the proposed method, underscoring its potential as a rapid and portable solution for the assessment of whole-grain foods.

Rose-like structure of calcium molybdate decorated on halloysite nanotubes as an electrocatalyst: Highly sensitive and selective electrochemical determination of promethazine hydrochloride in biological and environmental samples: Density functional theory studies

In recent years, the significance of Promethazine hydrochloride (PMZ) drugs has grown exponentially in both human and veterinary healthcare systems. Improperly getting rid of residues can contaminate environmental samples and food products. Therefore, a rapid detection and efficient treatment of PMZ is highly desired. In this study, the hydrothermal synthesis of calcium molybdate supported on halloysite nanotubes (CMO/HNTs) is described, employing ultrasonication. Various spectrophotometric techniques were employed to characterize the resulting electrocatalyst. The synthesized CMO/HNTs were utilized for electrocatalytic detection of promethazine hydrochloride (PMZ) through CV and LSV methods. The electrochemical determination of PMZ yielded captivating results, showcasing excellent electrocatalytic performance. Notably, the study achieved a wider linear range (10 µM to 800 µM), a lower limit of detection (LOD) of 2.72 nM, and an advanced sensitivity (0.185 μA µM−1 cm−2). Additionally, the CMO/HNTs/GCE exhibited outstanding stability, repeatability, and selectivity. Additionally, the PMZ sensor was successfully implemented in real time for analyzing biological and environmental samples.

Investigation of Some Crown Ether Compounds for Electrochemical Determination of Dopamine

In this study, the use of three different crown ether-modified electrodes prepared by electropolymerization of different crown ether compounds (CE1, CE2 and CE3) on multi-walled carbon nanotube (MWCNT) modified glassy carbon electrode (GCE) surfaces was investigated for electrochemical dopamine determination. The number of cycles during the electropolymerization of crown ethers and the pH of the buffer solution were optimized. Under optimum conditions, the sensitivities of MWCNT-modified GCE and crown ether-MWCNT-modified electrodes were determined in the range of 4.0×10-6 – 5.7×10-4 M dopamine. The sensitivity of MWCNT/GCE was found to be 6.71 µA mM-1, while the sensitivities of CE1/MWCNT/GCE, CE2/MWCNT/GCE and CE3/MWCNT/GCE were 19.53, 16.32 and 20.80 µA mM-1, respectively. The performance characteristics of the crown ether-MWCNT-modified electrodes such as detection limit, quantification limit, reusability and reproducibility were also investigated. The study showed that crown ether compounds significantly enhanced the electrochemical response in dopamine determination.

The Influence of Thermal Treatment of Activated Carbon on Its Electrochemical, Corrosion, and Adsorption Characteristics

Activated carbons can be applied in various areas of our daily life depending on their properties. This study was conducted to investigate the effect of thermal treatment of activated carbon on its properties, considering its future use. The characteristics of activated carbon heat-treated at temperatures of 1500, 1800, and 2100 °C based on its future use are presented. The significant effect of the treatment temperature on morphological, adsorption, electrochemical, and corrosion properties was proved. Increasing the temperature above 1800 °C resulted in a significant decrease in the specific surface area (from 969 to 8 m2·g−1) and material porosity—the formation of mesopores (20–100 nm diameter) was observed. Simultaneously, adsorption capability, double layer capacity, and electrochemically active surface area also decreased, which helped to explain the shape of cyclic voltammograms recorded in 2,4-dichlorophenoxyacetic acid and in supporting electrolytes. However, a significant increase in corrosion resistance was found for the carbon material treated at a temperature of 2100 °C (corrosion current decreased by 23 times). Comparison of morphological, adsorption, corrosion, and electrochemical characteristics of the tested activated carbon, its applicability as an electrode material in electrical energy storage devices, and materials for adsorptive removal of organic compounds from wastewater or as a sensor in electrochemical determination of organic compounds was discussed.

Sensitive Electrochemical Determination of Quercetin in Fruit Juice Using an Aluminum Hydroxide Oxide–Titanium Carbide MXene Composite

A hybrid material composed of aluminum hydroxide oxide (AlOOH) and titanium carbide (Ti3C2) nanosheets was synthesized and used for electrochemical sensing of quercetin. The Ti3C2 nanosheets were synthesized using a selective etching technique, followed by the hydrothermal growth of AlOOH on the nanosheet surfaces. Cyclic voltammetry and differential pulse voltammetry were performed to evaluate the electrochemical properties of the AlOOH@Ti3C2 nanocomposites. Under optimal conditions, the AlOOH@Ti3C2 modified electrode exhibited wide linearity and high sensitivity. The practicality of the sensor was verified through an interference study and real sample analysis. Additionally, the sensing platform exhibited outstanding operational and storage stability.

Electrochemical determination of phenolic antioxidant BHT in cosmetic, food and water samples

BHT, an antioxidant often employed in several industries such as food, cosmetics, and food packaging, has raised public health concerns due to its possible toxicological consequences. These concerns originate from both the inherent properties of BHT itself as a result of its usage as an antioxidant. This research presents a novel sensor that uses a combination of a rare lanthanide element and a metal oxide as substrate modifiers on graphene nanopowder. Three independent electrochemical methods, cyclic voltammetry, differential pulse voltammetry, and electrochemical impedance spectroscopy, were used to analyze the electrode modification process. Excellent linearity in the concentration range of 1.0 × 10−12–1.0 × 10−7 M was obtained under the optimal conditions of the technique, with a detection limit of 3.0 × 10−13 M. Repeatability, reproducibility, and stability studies were performed using the proposed sensor. The RSD value for the reproducibility study was 2.91 %. For the within-day repeatability, the repeatability was determined to be 1.97 % for the sensor. After 7 days, the stability studies indicated a decrease up to a value of 90.89 % of the initial value from the first day of assessment.

Metal-Organic Framework-Based Nanostructures for Electrochemical Sensing of Sweat Biomarkers.

Sweat is considered the most promising candidate to replace conventional blood samples for noninvasive sensing. There are many tools and optical and electrochemical methods that can be used for detecting sweat biomarkers. Electrochemical methods are known for their simplicity and cost-effectiveness. However, they need to be optimized in terms of selectivity and catalytic activity. Therefore, electrode modifiers such as nanostructures and metal-organic frameworks (MOFs) or combinations of them were examined for boosting the performance of the electrochemical sensors. The MOF structures can be prepared by hydrothermal/solvothermal, sonochemical, microwave synthesis, mechanochemical, and electrochemical methods. Additionally, MOF nanostructures can be prepared by controlling the synthesis conditions or mixing bulk MOFs with nanoparticles (NPs). In this review, we spotlight the previously examined MOF-based nanostructures as well as promising ones for the electrochemical determination of sweat biomarkers. The presence of NPs strongly improves the electrical conductivity of MOF structures, which are known for their poor conductivity. Specifically, Cu-MOF and Co-MOF nanostructures were used for detecting sweat biomarkers with the lowest detection limits. Different electrochemical methods, such as amperometric, voltammetric, and photoelectrochemical, were used for monitoring the signal of sweat biomarkers. Overall, these materials are brilliant electrode modifiers for the determination of sweat biomarkers.

Trimetallic ZIFs-derived nanoarchitecture for portable wireless electrochemical determination of chlorogenic acid in natural medicine and food samples

In this paper, a novel trimetallic zeolitic imidazolate frameworks (ZnCoMn-ZIFs) was successfully synthesized by a facile one-pot method at room temperature, which was further used to prepare a triatomic site anchored in N-doped carbon (Co2MnN8@C) hybrid nanostructure via a pyrolysis method. The synthesized Co2MnN8@C was modified on the screen-printed carbon electrode, and the modified electrode was used for the portable wireless sensitive determination of chlorogenic acid (CGA) by differential pulse voltammetry. The Co2MnN8@C exhibited large surface area and excellent catalytic activity with increasing Co and Mn sites, which could selectively combine with CGA to enhance the sensitivity of the electrochemical sensor. Under the optimized conditions, the constructed sensor had wider linear ranges for CGA analysis from 0.05–10.0 μmol/L and 10.0–100.0 μmol/L with a detection limit of 0.0075 μmol/L (3S0/S). The sensor was successfully applied to detect CGA in natural medicine and food samples with satisfied recoveries. Therefore, the proposed strategy may stimulate the exploration of trimetallic ZIFs with more active sites for the development of sensitive electrochemical sensors.