Herein, the Nd(OH)3-NiTe2 nanoparticles were synthesized by hydrothermal synthesis. The crystal structure, morphology and surface element composition were characterized by scanning electron microscopy, transmission electron microscopy, X-ray diffraction and X-ray photoelectron spectroscopy. At the same time, the electrocatalytic performance of Nd(OH)3-NiTe2 for glucose oxidation in alkaline electrolyte was determined by cyclic voltammetry, chronoamperometry and electrochemical impedance spectroscopy (EIS). It exhibits a high peak current density of about 21.09 mA/cm2 for glucose oxidation. The low semicircle diameter of 8000 Ω means fast electron transfer of Nd(OH)3-NiTe2. The oxidation signal of glucose at 0.5 V tends to be constant within 36000 s. Electrochemical experiments show that Nd(OH)3-NiTe2 nanoparticles exhibit good electrocatalytic activity and stability for the oxidation of glucose, which proves their potential application in the field of fuel cells.