Electro-discharge machining (EDM) is a useful non-conventional machining operation frequently applied to make different complex geometries in any conducting material. The objectives of the present paper are to study the effect of a variation of thermo-physical properties (TPP) of three different tool materials on EDM performances. The different performances compared in this paper are: material removal rate (MRR), tool-wear rate (TWR), surface roughness (SR), radial overcut (ROC), surface-crack density (SCD) and surface hardness. Two of the most widely used work piece materials, such as corrosion-resistant austenitic stainless steel (SS316) and high strength corrosion-resistance titanium alloy (Ti-6Al-4V), are machined with the help of three different tools by varying input current and maintaining constant pulse-on time, pulse-off time and flushing pressure. Microstructural studies of the tool tip surface after machining have also been carried out. It is found that among these three tool materials, the copper tool showed the best machining performance with respect to material removal rate, radial overcut, surface finish and surface-crack density. This work will help industry personnel to choose a suitable tool for a specific work piece material.