The interplay of electricity supply, enterprise development, air pollution, and human health is manifested in many developing countries. Most developing countries are striving to improve their industrial output and standard of living, within their national economic development programs and the Millennium Development Goals MDGOs . The availability of sustainable energy systems for powering industrial and civil facilities has emerged as a key determinant of the success of critical economic development programs. Because of the desirability of spreading development to rural areas to stem human migration to cities that have inadequate facilities and poor national electricity grids, many system planners in developing countries target distributed energy generation. Such distributed sources, which need to be managed locally but interlinked nationally for integration into national economic development programs, can be configured to power the many factories, schools, health facilities, and other industrial sectors that must be developed to improve socioeconomic conditions in developing countries. Currently, the primary source of electric power in most rural areas in developing countries is the diesel-fueled generator. This engine is ubiquitous in both urban and rural areas. The transportation and storage of diesel fuel for its use are required for a continuous supply of electricity. Unavailability and unaffordablity of fuel, especially in far-flung rural communities, often result in interruptions of the electric power supply and temporary cessation of power in dependent industrial operations. There is also the issue of air pollution by power generators that have been in commission for too long. Many fatalities result each year because people living in poorly ventilated houses operate generators indoors and inhale noxious fumes. In some countries where the price of fuel is excessively high particularly in non-oil-producing countries , dependence on diesel-fueled generators as the primary source of electricity supply can raise the cost for small businesses to produce goods and services to levels of unsustainability. As much as 40% of production costs have been attributed to energy investments in the operation of some factories in developing countries. The net effect of this circumstance is that these factories—some of which are established through microcredit schemes, thrift arrangements, direct lending, and community financing—may not be financially sustainable, resulting in inability to meet regional sustainable development targets. Development of large-scale electric power installations—most of which could be based on sustainable energy systems such as hydroelectricity, geothermal processes, wind farms, and gas-fired systems—is necessary. The implementation of these power generation systems, which is targeted in most strategic electricity supply plans of the developing countries, needs to complemented by adequate power transmission and distribution systems. These are requirements for decommissioning diesel-fueled electric power generators that have attendant economic, environmental, and health disadvantages in developing countries. Of course, as implied herein, grid electricity from large-scale installations would be available at costs that are lower than that of small, isolated generators. An additional option in rural or neighborhood electricity supply is to develop small generating facilities by using locally available resources, such as biomass, sunlight, and wind. As national, regional, and global development agencies and banks configure economic development plans and projects with sustainability requirements, local capacity for exploring options should be engaged or developed. Often such options can be fully assessed only through targeted research. It requires involving some local stakeholders to promote program and project sustainability.