Electrical Activity Of Small Intestine Research Articles

Endotoxemia in metabolic syndrome and some mechanisms of its development

The aim. Assessment of the relationship between the occurrence of endotoxemia and impaired resorption function of the small intestine, arrhythmia of the motility of the stomach and intestines, and excessive bacterial growth in the metabolic syndrome (MS).Materials and methods. 62 patients with MS were examined. The average age was 48.62+3.75 years. The motor function of the gastrointestinal tract was studied using peripheral electrogastroenterocolography. To assess the absorption processes in the small intestine, stress tests with glucose and d-xylose were used. Blood endotoxin level, quantitative and& qualitative composition of parietal microbiota of small intestine were determined using an Agilent gas chromatograph with mass-selective and flame-ionization detectors (Agilent Technologies, USA).Results. 82.9% of the examined patients with MS showed clinical signs of intestinal damage. The electrical activity of& the& small intestine departments in the postprandial period was low in 70% of patients. The electrical activity of& the& colon on an empty stomach was not changed, and after a food load was reduced. Discoordination of motility is observed between small intestine and the colon, aggravated after food stimulation. A significant decrease in the rhythm of contractions is observed at the frequencies of the jejunum, ileum, and colon both on an empty stomach and in the postprandial period, which indicates a weakening of propulsive bowel contractions in patients with MS. In patients with MS, an increase in& the& absorption of glucose and d-xylose was revealed in comparison with the group of healthy individuals. In patients with MS, excessive bacterial growth in small intestine is observed mainly due to conditionally pathogenic microbiota strains. According to the results of the study of blood endotoxin level in patients with MS, a significant increase was revealed in comparison with the control group. Correlation analysis showed a moderate negative relationship between the level of endotoxin and electrical activity of small intestine, between the level of endotoxin and the ratio of the ratio of& the& colon to the ileum. A moderate positive relationship was established between the degree of endotoxemia increase and glucose absorption in small intestine.Conclusion. A study of the level of endotoxin and indicators of excessive bacterial growth, motor evacuation and resorption functions of small intestine revealed important pathogenetic patterns regarding the contributing role of the latter in& the development of endotoxemia in patients with MS.

Measurement of electrical activity of the human small intestine using surface electrodes

Electrical activity of the human small intestine is usually measured by implanted or intraluminal electrodes. The application of these invasive techniques is, however, very limited. In this paper, a noninvasive technique is introduced to measure electrical activity of the small intestine by placing electrodes on the abdominal skin over the small intestine. Surface recordings were obtained in ten healthy volunteers, three patients with total gastrectomy and five patients with gastroparesis (a slight degree of paralysis of the mucosal coat of the stomach) with implanted electrodes on the serosa of the duodenum. An omnipresent 9-12 cpm electrical activity was observed in all surface recordings. Our findings from the surface electrodes were consistent with those reported in the literature via implanted or intubated electrodes. It is concluded that the technique described in this paper provides a noninvasive way to measure electrical activity of the small intestine. It may have potential application in medical research and clinical diagnosis.

Effect of secretin on electrical activity of small intestine.

The effect of intravenously administered secretin (0.5, 2.0, 6.0 U/kg-h) and intraduodenal acidification (13.2 meq/h HCl) on the electrical activity of the small bowel of three conscious dogs with gastric and duodenal cannulas was observed. Electrical activity was recorded in fasted as well as fed conditions through silver wire electrodes implanted along the entire length of the small bowel. Intravenous infusion of secretin in all dosages and in all dogs delayed the onset of the interdigestive myoelectric complex and reduced the total percentage of slow waves with superimposed spike potentials. Intraduodenal acidification also inhibited the interdigestive myoelectric complex, which developed incompletely with fewer action potentials on slow waves. Secretin did not produce any alteration in the fed pattern of activity, slow-wave frequency, or the caudal migration of the interdigestive myoelectric complex. The present study indicates that the nuerohumoral mechanisms responsible for initiation of the interdigestive myoelectric complex may be different from those responsible for its caudal migration.

Effects of pentagastrin on electrical activity of small intestine of the dog.

Effects of pentagastrin on electrical activity of small intestine of the dog.

Effects of prostaglandin E1 on canine gastrointestinal motility in vivo and human isolated smooth muscle in vitro (author's transl)

The present study was undertaken to investigate some of the effects of prostaglandin E1 ongastrointestinal motility in dogs and human isolated smooth muscle strips. Electromyographyand intraluminal manometry were used in the former and kymography in the latter. The results obtained were as follows:1. In dogs, the intravenous injection of 0.25 to 2.0 μg/kg of PGE1 caused the potentiation of peristaltic movement and the increase in electrical activity of small intestine.2. At higher doses (more than 2.5 μg/kg) of PGE1, the generation of action potential was rather depressed and peristaltic movement was also abolished. However, the intraluminal pressures recorded from the various portions of gastrointestinal tract always showed the patterns of contraction.3. Discrepancies in results between EMG and manometry have been attributed by Bennett and his colleagues to the constrictive response of longitudinal muscle which is greater than the relaxing response of circular muscle.4. Circular muscle strips of human stomach and colon usually showed the inhibition of activityby PGE1 in the concentration of 10-8 to 10-5 g/ml. On the other hand, longitudinal muscle strips showed the contraction patterns in the same concentration range of PGE1, but, in most cases, slight relaxations were observed before the contraction.

Simulation of slow-wave electrical activity of small intestine.

Simulation of slow-wave electrical activity of small intestine.

Effect of feeding on electrical activity of dog's small intestine.

ARTICLESEffect of feeding on electrical activity of dog's small intestineEJ McCoy, and RD BakerEJ McCoy, and RD BakerPublished Online:01 Jun 1968https://doi.org/10.1152/ajplegacy.1968.214.6.1291MoreSectionsPDF (1 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformationCited ByMotility of the Small Intestine and Colon27 November 2015Physiology of the small bowel: A new approach using MRI and proposal for a new metric of functionMedical Hypotheses, Vol. 76, No. 6Meal-Induced Acceleration of Tablet Transit Through the Human Small Intestine4 November 2008 | Pharmaceutical Research, Vol. 26, No. 2Small Intestinal MotilityÍleo paralítico postoperatorioCirugía Española, Vol. 69, No. 3Bipolar electrode implantation for myoelectrical recordings of rat bowelDigestive Diseases and Sciences, Vol. 41, No. 7Postoperative ileusDigestive Diseases and Sciences, Vol. 35, No. 1Gastrointestinal Physiology, 1895–1975: Motility1 January 2011Alterations of small intestine motility by bacteria and their enterotoxins1 January 2011Computer-assisted method for the analysis of postprandial gastrointestinal motility in conscious dogsMedical and Biological Engineering and Computing, Vol. 27, No. 5Gastrointestinal myoelectric activity following abdominal operations in the opossumWorld Journal of Surgery, Vol. 9, No. 4Different meals produce different digestive motility patternsDigestive Diseases and Sciences, Vol. 29, No. 3Intestinal motility after infusion of arachis oil into duodenum and ileum of dogsDigestive Diseases and Sciences, Vol. 29, No. 2Nervous Control of Intestinal MotilityA method for long-term recording of intestinal mechanical and electrical activity in the unrestrained ratJournal of Pharmacological Methods, Vol. 6, No. 3Effect of feeding on electrical activity of the duodenal smooth muscles in dogsBulletin of Experimental Biology and Medicine, Vol. 86, No. 4Effect of an elemental diet on the electrical activity of the small intestine in dogsJournal of Surgical Research, Vol. 20, No. 6Gastric Control of Duodenal Electric Activity – The Function of the Gastroduodenal Junction27 September 2008 | Archives Internationales de Physiologie et de Biochimie, Vol. 83, No. 5Electrical and contractile activities of the small intestine of the catThe American Journal of Digestive Diseases, Vol. 19, No. 2Motility of the Human Digestive Tract under Resting Conditions and After Ingestion of Food2 March 2011 | Upsala Journal of Medical Sciences, Vol. 77, No. 3A study in the dog and cat of the electrical activity of the small intestine some months after transection and transplantation of the gutLife Sciences, Vol. 10, No. 5Electrical activity of small intestinal smooth muscleThe American Journal of Surgery, Vol. 117, No. 6Intestinal slow waves: Decrease in propagation velocity along upper small intestineThe American Journal of Digestive Diseases, Vol. 14, No. 1 More from this issue > Volume 214Issue 6June 1968Pages 1291-1295 Copyright & PermissionsCopyright © 1968 by American Physiological Societyhttps://doi.org/10.1152/ajplegacy.1968.214.6.1291PubMed5649484History Published online 1 June 1968 Published in print 1 June 1968 Metrics