Simple SummaryThe conservation of Tibetan brown bear (Ursus arctos pruinosus) and its habitat is of great value to the conservation of sympatric species, which helps to maintain the health and stability of the regional ecosystem. In recent years, human–bear conflicts (HBCs) have intensified in the Sanjiangyuan Region in Qinghai Province, China, decreasing the tolerance of local herders of the species and seriously affecting the motivation of local communities to protect brown bears and other wildlife, with retaliatory killing posing a threat to their survival. Timely development of effective measures and countermeasures for mitigating HBCs is crucial to protect brown bears. The mitigation or resolution of HBC issues is beneficial to both the promotion of people’s livelihoods and the conservation of brown bears on the Qinghai-Tibetan Plateau (QTP). At present, there is still a lack of research on the mitigation measures of HBCs on the QTP. This study combined field surveys, semi-structured interviews, and HBC seminars to understand the effectiveness of current mitigation measures and to propose potential mitigation measures in the hinterland of the QTP. This work proposed targeted mitigation measures for HBCs taking into account existing HBC management practices in China and abroad, and the unique geographical environment, laws and regulations, folk culture, and religious beliefs of local regions. Although this study was limited to a single species on the QTP, the results herein are useful for drafting national-level wildlife conservation policies, compensation programs for wildlife damage, and natural resource conservation regulations.Personal injury and property damage caused by wildlife can worsen the relationship between humans and wildlife. In recent years, conflicts between herders and Tibetan brown bears (Ursus arctos pruinosus) (human–bear conflicts; HBCs) on the Qinghai-Tibetan Plateau have increased dramatically, severely affecting community motivation for the conservation of brown bears and other species. Understanding the types, effectiveness, and flaws of current HBC mitigation measures is critical to develop effective strategies to alleviate HBC. From 2017 to 2019, we conducted a systematic field survey regarding HBCs on the Qinghai-Tibetan Plateau. In addition, we invited bear specialists and multiple interest groups to hold an HBC seminar and proposed some potential mitigation strategies. We surveyed 312 families via semi-structured interviews and documented 16 types of HBC mitigation measures. A total of 96% of respondents were using more than two mitigation measures simultaneously. The effectiveness evaluation of HBC mitigation measures showed that: (1) removing food from winter homes while herders were at their summer pastures and asking people to keep watch of winter homes were effective at protecting food and houses; (2) traditional grazing methods (human guarding of livestock all day) and solar soundboxes (attached to livestock) were effective at protecting free-range livestock; (3) solar street lights had a deterrent effect on brown bears and were effective in protecting livestock, houses, and people; and (4) due to the unstable power supply of photovoltaic cells and improper installation of ground wires, electric fences were not ideal in practice. Evaluation of the potential mitigation measures at the seminar showed that upgrading electric fence technology, expanding electric fence pilot areas, installing diversionary feeders, and introducing bear spray were the most optimal solutions. This study provides a scientific basis for creating human–bear coexistence plans on the Qinghai-Tibet Plateau.