Enhancing the energy efficiency of thermal systems reduces their consumption, lowers costs, and reduces undesired environmental impact, thus making these systems more sustainable. The current work introduces a passive method for heat transfer enhancement that is carried out using natural convection by nanofluid. This work introduces a computational study of the process of natural convection within a square cavity containing Cu/H2O nanofluid. The cavity wall on the left side undergoes partial isothermal heating, while the opposing side is fully cooled isothermally, with all other boundaries maintained adiabatic. A mathematical model formulated based on a 2-D model was used to provide the solution for the system of governing equations of mass, momentum, and energy conservation, employing the finite element technique. A commercial CFD package is utilized to perform the computational simulation. The present investigation delves into the impact of the Rayleigh number, nanoparticle concentration, heater length, and heater location on the flow field and heat transfer characteristics. The model outcomes were displayed for a wide range of the pertinent parameters as 103 ≤ Ra ≤ 106, 0.25 ≤ lh ≤ 1.0, 0.125 ≤ hc ≤ 0.875, and 0.02 ≤ ϕ ≤ 0.10. Also, correlation equations relating the average Nusselt number to these crucial parameters are derived. These equations are simple and can be applied in practice easily in many fields, such as electric and electronic equipment cooling and thermal management of heat sources. Also, these equations gather all the parameters that affect the heat transfer process. They are shedding light on the intricate interplay between these parameters in the natural convection heat transfer process.