Controversy exists regarding the most appropriate anesthetic strategy to maximize the possibility of arrhythmia induction/maintenance in those individuals requiring general anesthesia for the ablation of arrhythmia substrates. The anesthetic regimen used at our facility consists of a light combined inhalational (sevoflurane) and intravenous (midazolam/fentanyl) general anesthesia (GA), hypercarbia, normothermia (37.0 C), and mostly spontaneous breathing. We investigated the rate of arrhythmia inducibility with this anesthesia strategy. To study the rate of inducibility and maintainence of arrhythmias with the anesthetic regimen used at our facility. A single center retrospective study was performed. Data from subjects 2-44 years undergoing elective electrophysiology study (EPS) for evaluation of supraventricular tachycardia, ectopic atrial tachycardia, premature ventricular contractions (PVC)/ventricular tachycardia (VT) or WPW (Wolff-Parkinson-White) from 2020 to 2022 were included. The primary outcome was positive EPS, defined as successful induction of clinical tachyarrhythmias. 134 subjects were evaluated: 57% male; mean age 14.5+/-6.3 years, 10% adult (age above 18 years). EPS conducted for documented arrythmia of SVT 46%, atrial tachycardia 4%, atrial flutter 7%, PVC 3%, VT 5%, A fib 1%, and WPW 32%. A positive EPS occurred in 74% of cases overall. Arrhythmia was induced in 85% of adult subjects versus 73% of children (p=0.37), and in 70% male versus 79% of female subjects (p=0.23). When arrhythmias were documented, they were inducible in 94.4% of cases; when there was no antecedent history of arrhythmias (such as asymptomatic WPW), they were still induced 36.9% (p<0.001). Overall, a positive EPS occurred in 52% of WPW cases. PVCs and VT remained present after anesthesia (or were inducible by pharmacologic/pacing maneuvers) in 100% of cases. Selected assessment of refractory periods during post-ablation protocols suggests that hypercarbia may be one of the key components of the strategy, with a lowering of AV nodal refractory periods of as much as 40 msec. Our data suggests that an inhalational anesthetic strategy is extremely effective at maintaining arrhythmia inducibility when combined with other strategies that preserve cardiac excitability and refractory periods. Additionally, this strategy may be more effective for the induction and maintenance of arrhythmias in PVC/VT cases.