Objective: To assess the post operative wound complication after open cholecystectomy for uncomplicated Cholelithiasis. Design: Cross sectional descriptive. Setting: Surgical unit of Khyber Teaching Hospital Peshawar Pakistan. Patients: 223 patients underwent elective open cholecystectomy January 2011 to July 2012. Results: 90% patients had normal healing (grade 0 or I) ,7.5% had minor complications (grade II or III), 2.5% patients had major complication (grade IV or V) recorded during hospital stay. On follow-up in out-patient department 81%patients found to have normal healing (grade 0 or I), 15% patients had minor complications (grade II or III) and 4% patients had major complications (grade IV or V). There was an increase noted in wound grades during follow up for surgical site infections as compared to their record during hospital stay. Conclusions: Southampton wound scoring system is a useful tool for detection of surgical site infection and standardization. Auditing of surgical site infection by Southampton wound scoring will help the patient, surgical team and sterilization protocol to be improved.