BACKGROUND CONTEXT Previous literature has demonstrated mixed results regarding the correlation between patient reported allergies and their pain, function, and satisfaction scores with elective spine surgery. A better understanding of the correlation is important for preoperative risk factor assessment and management. PURPOSE The objective of this study was to investigate the correlation between patient reported allergies and preoperative Oswestry Disability Index (ODI), Neck Disability Index (NDI) and Patient-Reported Outcomes Measurement System (PROMIS) scores. STUDY DESIGN/SETTING Retrospective review at a single institution from May 2017-October 2018. PATIENT SAMPLE All patients undergoing elective cervical, thoracolumbar, and lumbar spine surgery at a single institution who had completed preoperative ODI, NDI, and PROMIS questionnaires. OUTCOME MEASURES The PROMIS, ODI and NDI scores were utilized. METHODS All patients undergoing elective cervical, lumbar procedures between May 2017 and October 2018 were included. Baseline demographic information was recorded, as well as all reported allergies or adverse reactions. PROMIS scores, ODI and NDI were recorded. Hierarchical multiple linear regressions were used to assess the relationship between total number of allergies and the preoperative pain and function scores. RESULTS A total of 570 patients were included (476 lumbar, 94 cervical). The mean number of allergies reported was 1.89 ± 2.32. The mean preoperative ODI and NDI scores were 46.39 ±17.67, and 43.47 ±16.51, respectively. The mean preoperative PROMIS Physical Health and PROMIS Mental Health scores were 37.21±6.54 and 43.89 ±9.26, respectively. Hierarchical multiple linear regression showed that total number of reported allergies shared a statistically significant negative relationship with all of the following scores: ODI (B = 0.83,p=.02), NDI (B = 1.45, p=.02), PROMIS Physical Health (B = -0.29, p=.013), PROMIS Mental Health (B = -0.38, p=.024). CONCLUSIONS Patient reported allergies share a statistically significant negative relationship with preoperative pain and function scores; as patients have increasing total number of allergies, the ODI/NDI scores become worse (increase), and the PROMIS scores become worse (decrease). FDA DEVICE/DRUG STATUS This abstract does not discuss or include any applicable devices or drugs. Previous literature has demonstrated mixed results regarding the correlation between patient reported allergies and their pain, function, and satisfaction scores with elective spine surgery. A better understanding of the correlation is important for preoperative risk factor assessment and management. The objective of this study was to investigate the correlation between patient reported allergies and preoperative Oswestry Disability Index (ODI), Neck Disability Index (NDI) and Patient-Reported Outcomes Measurement System (PROMIS) scores. Retrospective review at a single institution from May 2017-October 2018. All patients undergoing elective cervical, thoracolumbar, and lumbar spine surgery at a single institution who had completed preoperative ODI, NDI, and PROMIS questionnaires. The PROMIS, ODI and NDI scores were utilized. All patients undergoing elective cervical, lumbar procedures between May 2017 and October 2018 were included. Baseline demographic information was recorded, as well as all reported allergies or adverse reactions. PROMIS scores, ODI and NDI were recorded. Hierarchical multiple linear regressions were used to assess the relationship between total number of allergies and the preoperative pain and function scores. A total of 570 patients were included (476 lumbar, 94 cervical). The mean number of allergies reported was 1.89 ± 2.32. The mean preoperative ODI and NDI scores were 46.39 ±17.67, and 43.47 ±16.51, respectively. The mean preoperative PROMIS Physical Health and PROMIS Mental Health scores were 37.21±6.54 and 43.89 ±9.26, respectively. Hierarchical multiple linear regression showed that total number of reported allergies shared a statistically significant negative relationship with all of the following scores: ODI (B = 0.83,p=.02), NDI (B = 1.45, p=.02), PROMIS Physical Health (B = -0.29, p=.013), PROMIS Mental Health (B = -0.38, p=.024). Patient reported allergies share a statistically significant negative relationship with preoperative pain and function scores; as patients have increasing total number of allergies, the ODI/NDI scores become worse (increase), and the PROMIS scores become worse (decrease).